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Title: TMBIM-mediated Ca 2+ homeostasis and cell death

Ca 2+ is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca 2+ is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi Apparatus maintain high-concentration Ca 2+ stores. Under resting conditions, store Ca 2+ homeostasis is dynamically regulated to equilibrate between active Ca 2+ uptake and passive Ca 2+ leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca 2+ homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment.
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  1. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Report Number(s):
Journal ID: ISSN 0167-4889
Grant/Contract Number:
SC0012704; LDRD 15-034
Published Article
Journal Name:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Additional Journal Information:
Journal Name: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research; Journal Volume: 1864; Journal Issue: 6; Journal ID: ISSN 0167-4889
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES; Ca2+ homeostasis; Ca2+ signaling; cell death; apoptosis; Bax inhibitor-1; TMBIM; membrane proteins; cancer; cellular stress; Ca2+ channel structure.
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1389232