Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle
Abstract
Protein S-glutathionylation is an important reversible post-translational modification implicated in redox signaling. Oxidative modifications to protein thiols can alter the activity of metabolic enzymes, transcription factors, kinases, phosphatases, and the function of contractile proteins. However, the extent to which muscle contraction induces oxidative modifications in redox sensitive thiols is not known. The purpose of this study was to determine the targets of S-glutathionylation redox signaling following fatiguing contractions. Anesthetized adult male CB6F1 (BALB/cBy × C57BL/6) mice were subjected to acute fatiguing contractions for 15 min using in vivo stimulations. The right (stimulated) and left (unstimulated) gastrocnemius muscleswere collected 60 min after the last stimulation and processed for redox proteomics assay of S-glutathionylation.
- Authors:
-
- Univ. of Washington, Seattle, WA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1439099
- Report Number(s):
- PNNL-SA-135523
Journal ID: ISSN 2213-2317; PII: S2213231718303550
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Redox Biology
- Additional Journal Information:
- Journal Volume: 17; Journal Issue: C; Journal ID: ISSN 2213-2317
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Muscle contraction; Post-translational modification; S-glutathionylation; Redox signaling; Skeletal muscle; Thiol redox proteomics
Citation Formats
Kramer, Philip A., Duan, Jicheng, Gaffrey, Matthew J., Shukla, Anil K., Wang, Lu, Bammler, Theo K., Qian, Wei -Jun, and Marcinek, David J. Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. United States: N. p., 2018.
Web. doi:10.1016/j.redox.2018.05.011.
Kramer, Philip A., Duan, Jicheng, Gaffrey, Matthew J., Shukla, Anil K., Wang, Lu, Bammler, Theo K., Qian, Wei -Jun, & Marcinek, David J. Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. United States. https://doi.org/10.1016/j.redox.2018.05.011
Kramer, Philip A., Duan, Jicheng, Gaffrey, Matthew J., Shukla, Anil K., Wang, Lu, Bammler, Theo K., Qian, Wei -Jun, and Marcinek, David J. Wed .
"Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle". United States. https://doi.org/10.1016/j.redox.2018.05.011. https://www.osti.gov/servlets/purl/1439099.
@article{osti_1439099,
title = {Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle},
author = {Kramer, Philip A. and Duan, Jicheng and Gaffrey, Matthew J. and Shukla, Anil K. and Wang, Lu and Bammler, Theo K. and Qian, Wei -Jun and Marcinek, David J.},
abstractNote = {Protein S-glutathionylation is an important reversible post-translational modification implicated in redox signaling. Oxidative modifications to protein thiols can alter the activity of metabolic enzymes, transcription factors, kinases, phosphatases, and the function of contractile proteins. However, the extent to which muscle contraction induces oxidative modifications in redox sensitive thiols is not known. The purpose of this study was to determine the targets of S-glutathionylation redox signaling following fatiguing contractions. Anesthetized adult male CB6F1 (BALB/cBy × C57BL/6) mice were subjected to acute fatiguing contractions for 15 min using in vivo stimulations. The right (stimulated) and left (unstimulated) gastrocnemius muscleswere collected 60 min after the last stimulation and processed for redox proteomics assay of S-glutathionylation.},
doi = {10.1016/j.redox.2018.05.011},
journal = {Redox Biology},
number = C,
volume = 17,
place = {United States},
year = {2018},
month = {5}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 9 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Table 1: Known glutathionylation sites associated with altered protein function. Table of P-SSG modifications significantly affected by fatiguing contractions sorted by Excitation/contraction Coupling, Metabolism, Redox Regulation, and Other. Significance determined by p-value (≤ 0.05). Note: Some P-SSG sites were no longer significant with FDR correction.
All figures and tables
(7 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
The basics of thiols and cysteines in redox biology and chemistry
journal, March 2015
- Poole, Leslie B.
- Free Radical Biology and Medicine, Vol. 80
Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces
journal, December 2010
- Marino, Stefano M.; Gladyshev, Vadim N.
- Journal of Molecular Biology, Vol. 404, Issue 5
The cysteine proteome
journal, July 2015
- Go, Young-Mi; Chandler, Joshua D.; Jones, Dean P.
- Free Radical Biology and Medicine, Vol. 84
Glutathione and mitochondria
journal, July 2014
- Ribas, Vicent; GarcÃa-Ruiz, Carmen; Fernández-Checa, José C.
- Frontiers in Pharmacology, Vol. 5
Causes and Consequences of Cysteine S -Glutathionylation
journal, July 2013
- Grek, Christina L.; Zhang, Jie; Manevich, Yefim
- Journal of Biological Chemistry, Vol. 288, Issue 37
Glutaredoxin: Role in Reversible Protein S -Glutathionylation and Regulation of Redox Signal Transduction and Protein Translocation
journal, March 2005
- Shelton, Melissa D.; Chock, P. Boon; Mieyal, John J.
- Antioxidants & Redox Signaling, Vol. 7, Issue 3-4
Molecular Mechanisms and Clinical Implications of Reversible Protein S -Glutathionylation
journal, November 2008
- Mieyal, John J.; Gallogly, Molly M.; Qanungo, Suparna
- Antioxidants & Redox Signaling, Vol. 10, Issue 11
Protein S-glutathionylation: a regulatory device from bacteria to humans
journal, February 2009
- Dalle-Donne, Isabella; Rossi, Ranieri; Colombo, Graziano
- Trends in Biochemical Sciences, Vol. 34, Issue 2
The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function
journal, November 2015
- Kramer, Philip A.; Duan, Jicheng; Qian, Wei-Jun
- Frontiers in Physiology, Vol. 6
Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance
journal, August 2007
- Rhee, S. G.; Jeong, W.; Chang, T. -S.
- Kidney International, Vol. 72
Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training
journal, April 2013
- Wadley, G. D.; Nicolas, M. A.; Hiam, D. S.
- American Journal of Physiology-Endocrinology and Metabolism, Vol. 304, Issue 8
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
journal, October 2008
- Powers, Scott K.; Jackson, Malcolm J.
- Physiological Reviews, Vol. 88, Issue 4
Interactions Between Reactive Oxygen Species Generated by Contractile Activity and Aging in Skeletal Muscle?
journal, September 2013
- Jackson, Malcolm J.
- Antioxidants & Redox Signaling, Vol. 19, Issue 8
Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity
journal, April 2006
- Vasilaki, A.; Mansouri, A.; Van Remmen, H.
- Aging Cell, Vol. 5, Issue 2
Impact of Oxidative Stress on Exercising Skeletal Muscle
journal, April 2015
- Steinbacher, Peter; Eckl, Peter
- Biomolecules, Vol. 5, Issue 2
Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity
journal, February 2013
- Sakellariou, Giorgos Konstantinos; Vasilaki, Aphrodite; Palomero, Jesus
- Antioxidants & Redox Signaling, Vol. 18, Issue 6
Reactive Oxygen Species in Skeletal Muscle Signaling
journal, December 2012
- Barbieri, Elena; Sestili, Piero
- Journal of Signal Transduction, Vol. 2012
S-Glutathionylation signaling in cell biology: Progress and prospects
journal, August 2012
- Pastore, Anna; Piemonte, Fiorella
- European Journal of Pharmaceutical Sciences, Vol. 46, Issue 5
The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses
journal, August 2017
- Webb, Richard; Hughes, Michael; Thomas, Andrew
- Antioxidants, Vol. 6, Issue 3
Application of redox proteomics to skeletal muscle aging and exercise
journal, August 2014
- McDonagh, Brian; Sakellariou, Giorgos K.; Jackson, Malcolm J.
- Biochemical Society Transactions, Vol. 42, Issue 4
Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging
journal, September 2014
- McDonagh, Brian; Sakellariou, Giorgos K.; Smith, Neil T.
- Journal of Proteome Research, Vol. 13, Issue 11
Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria
journal, January 2013
- Frasier, Chad R.; Moukdar, Fatiha; Patel, Hetal D.
- Cardiovascular Research, Vol. 98, Issue 1
Antioxidants prevent health-promoting effects of physical exercise in humans
journal, May 2009
- Ristow, M.; Zarse, K.; Oberbach, A.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 21
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
journal, June 2013
- Siegel, Michael P.; Kruse, Shane E.; Percival, Justin M.
- Aging Cell, Vol. 12, Issue 5
Targeting redox biology to reverse mitochondrial dysfunction
journal, August 2013
- Marcinek, David J.; Siegel, Michael P.
- Aging, Vol. 5, Issue 8
Ectopic Catalase Expression in Mitochondria by Adeno-Associated Virus Enhances Exercise Performance in Mice
journal, August 2009
- Li, Dejia; Lai, Yi; Yue, Yongping
- PLoS ONE, Vol. 4, Issue 8
Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age
journal, November 2006
- Vasilaki, A.; McArdle, F.; Iwanejko, L. M.
- Mechanisms of Ageing and Development, Vol. 127, Issue 11
Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle
journal, September 2009
- Ljubicic, Vladimir; Joseph, Anna-Maria; Adhihetty, Peter J.
- Aging, Vol. 1, Issue 9
Resin-assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications
journal, December 2013
- Guo, Jia; Gaffrey, Matthew J.; Su, Dian
- Nature Protocols, Vol. 9, Issue 1
Proteomic identification and quantification of S-glutathionylation in mouse macrophages using resin-assisted enrichment and isobaric labeling
journal, February 2014
- Su, Dian; Gaffrey, Matthew J.; Guo, Jia
- Free Radical Biology and Medicine, Vol. 67
Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress
journal, December 2015
- Duan, Jicheng; Kodali, Vamsi K.; Gaffrey, Matthew J.
- ACS Nano, Vol. 10, Issue 1
Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state
journal, September 2010
- Matsumoto, Takashi; Kinoshita, Takayoshi; Kirii, Yasuyuki
- Biochemical and Biophysical Research Communications, Vol. 400, Issue 3
Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2
journal, September 2017
- Guo, Runyu; Zong, Shuai; Wu, Meng
- Cell, Vol. 170, Issue 6
Crystal structure of sarcoplasmic reticulum Ca2+-ATPase (SERCA) from bovine muscle
journal, April 2012
- Sacchetto, Roberta; Bertipaglia, Ilenia; Giannetti, Sara
- Journal of Structural Biology, Vol. 178, Issue 1
Skeletal Muscle Fatigue: Cellular Mechanisms
journal, January 2008
- Allen, D. G.; Lamb, G. D.; Westerblad, H.
- Physiological Reviews, Vol. 88, Issue 1
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
journal, November 2008
- Huang, Da Wei; Sherman, Brad T.; Lempicki, Richard A.
- Nucleic Acids Research, Vol. 37, Issue 1
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
journal, December 2008
- Huang, Da Wei; Sherman, Brad T.; Lempicki, Richard A.
- Nature Protocols, Vol. 4, Issue 1
Health benefits of physical activity: the evidence
journal, March 2006
- Warburton, D. E. R.
- Canadian Medical Association Journal, Vol. 174, Issue 6
Role of Exercise Therapy in Prevention of Decline in Aging Muscle Function: Glucocorticoid Myopathy and Unloading
journal, January 2012
- Seene, Teet; Kaasik, Priit
- Journal of Aging Research, Vol. 2012
Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions
journal, January 2014
- Mailloux, Ryan J.; Jin, Xiaolei; Willmore, William G.
- Redox Biology, Vol. 2
Protein Glutathionylation in Cardiovascular Diseases
journal, October 2013
- Pastore, Anna; Piemonte, Fiorella
- International Journal of Molecular Sciences, Vol. 14, Issue 10
A two-faced cysteine residue modulates skeletal muscle contraction . Focus on “ S -nitrosylation and S -glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca 2+ sensitivity in rat fast-twitch muscle fibers
journal, March 2017
- de Winter, Josine M.; Ottenheijm, Coen A. C.
- American Journal of Physiology-Cell Physiology, Vol. 312, Issue 3
S -Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans: S -Glutathionylation of TnI f increases Ca 2+ sensitivity
journal, February 2012
- Mollica, J. P.; Dutka, T. L.; Merry, T. L.
- The Journal of Physiology, Vol. 590, Issue 6
The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways
journal, March 2011
- Krüger, Martina; Linke, Wolfgang A.
- Journal of Biological Chemistry, Vol. 286, Issue 12
S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding
journal, March 2014
- Alegre-Cebollada, Jorge; Kosuri, Pallav; Giganti, David
- Cell, Vol. 156, Issue 6
Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity
journal, January 2018
- Giganti, David; Yan, Kevin; Badilla, Carmen L.
- Nature Communications, Vol. 9, Issue 1
Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1
journal, December 2006
- Aracena-Parks, Paula; Goonasekera, Sanjeewa A.; Gilman, Charles P.
- Journal of Biological Chemistry, Vol. 281, Issue 52
Cross talk between Ca 2+ and redox signalling cascades in muscle and neurons through the combined activation of ryanodine receptors/Ca 2+ release channels
journal, November 2005
- Hidalgo, Cecilia
- Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 360, Issue 1464
Peroxynitrite Modification of Protein Thiols: Oxidation, Nitrosylation, and S-Glutathiolation of Functionally Important Cysteine Residue(s) in the Sarcoplasmic Reticulum Ca-ATPase †
journal, September 1999
- Viner, Rosa I.; Williams, Todd D.; Schöneich, Christian
- Biochemistry, Vol. 38, Issue 38
Hydrogen Peroxide–Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse Heart
journal, August 2013
- Qin, Fuzhong; Siwik, Deborah A.; Lancel, Steve
- Journal of the American Heart Association, Vol. 2, Issue 4
Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
journal, September 1998
- Trapp, Stefan; Tucker, Stephen J.; Ashcroft, Frances M.
- Journal of General Physiology, Vol. 112, Issue 3
How mitochondria produce reactive oxygen species
journal, December 2008
- Murphy, Michael P.
- Biochemical Journal, Vol. 417, Issue 1
Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
journal, June 2015
- Liemburg-Apers, Dania C.; Willems, Peter H. G. M.; Koopman, Werner J. H.
- Archives of Toxicology, Vol. 89, Issue 8
Mitochondrial Glutathione, a Key Survival Antioxidant
journal, November 2009
- Marí, Montserrat; Morales, Albert; Colell, Anna
- Antioxidants & Redox Signaling, Vol. 11, Issue 11
S-glutathionylation of glyceraldehyde-3-phosphate dehydrogenase induces formation of C150-C154 intrasubunit disulfide bond in the active site of the enzyme
journal, December 2017
- Barinova, K. V.; Serebryakova, M. V.; Muronetz, V. I.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1861, Issue 12
Posttranslational Modification of Glyceraldehyde-3-phosphate Dehydrogenase by S-Nitrosylation and Subsequent NADH Attachment
journal, February 1996
- Mohr, Susanne; Stamler, Jonathan S.; Brüne, Bernhard
- Journal of Biological Chemistry, Vol. 271, Issue 8
Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion
journal, November 2002
- Eaton, Philip; Wright, Neville; Hearse, David J.
- Journal of Molecular and Cellular Cardiology, Vol. 34, Issue 11
Isotope-Coded Affinity Tag (ICAT) Approach to Redox Proteomics: Identification and Quantitation of Oxidant-Sensitive Cysteine Thiols in Complex Protein Mixtures
journal, December 2004
- Sethuraman, Mahadevan; McComb, Mark E.; Huang, Hua
- Journal of Proteome Research, Vol. 3, Issue 6
Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue
journal, April 2000
- Reddy, Sharanya; Jones, A. Daniel; Cross, Carroll E.
- Biochemical Journal, Vol. 347, Issue 3
Quantitative Analysis of Redox-Sensitive Proteome with DIGE and ICAT
journal, August 2008
- Fu, Cexiong; Hu, Jun; Liu, Tong
- Journal of Proteome Research, Vol. 7, Issue 9
S-glutathionylation reactions in mitochondrial function and disease
journal, November 2014
- Mailloux, Ryan J.; Willmore, William G.
- Frontiers in Cell and Developmental Biology, Vol. 2
Sites and Mechanisms of Aconitase Inactivation by Peroxynitrite: Modulation by Citrate and Glutathione
journal, August 2005
- Han, Derick; Canali, Raffaella; Garcia, Jerome
- Biochemistry, Vol. 44, Issue 36
Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry
journal, May 2013
- Kumar, Vikas; Kleffmann, Torsten; Hampton, Mark B.
- Free Radical Biology and Medicine, Vol. 58
Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions
journal, April 2014
- Mailloux, Ryan J.; Xuan, Jian Ying; McBride, Skye
- Journal of Biological Chemistry, Vol. 289, Issue 21
Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria
journal, August 2016
- Mailloux, Ryan J.; Treberg, Jason R.
- Redox Biology, Vol. 8
Mass Spectrometry Profiles Superoxide-Induced Intramolecular Disulfide in the FMN-Binding Subunit of Mitochondrial Complex I
journal, December 2008
- Zhang, L.; Xu, H.; Chen, C.
- Journal of the American Society for Mass Spectrometry, Vol. 19, Issue 12
Site-Specific S-Glutathiolation of Mitochondrial NADH Ubiquinone Reductase
journal, April 2007
- Chen, Chwen-Lih; Zhang, Liwen; Yeh, Alexander
- Biochemistry, Vol. 46, Issue 19
Quantitative Mapping of Reversible Mitochondrial Complex I Cysteine Oxidation in a Parkinson Disease Mouse Model
journal, January 2011
- Danielson, Steven R.; Held, Jason M.; Oo, May
- Journal of Biological Chemistry, Vol. 286, Issue 9
Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II
journal, August 2016
- Koenitzer, Jeffrey R.; Bonacci, Gustavo; Woodcock, Steven R.
- Redox Biology, Vol. 8
Mitochondrial Complex II in the Post-ischemic Heart
journal, November 2007
- Chen, Yeong-Renn; Chen, Chwen-Lih; Pfeiffer, Douglas R.
- Journal of Biological Chemistry, Vol. 282, Issue 45
S- Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics
journal, November 2016
- Módis, Katalin; Ju, YoungJun; Ahmad, Akbar
- Pharmacological Research, Vol. 113
Redox Regulation of Mitochondrial ATP Synthase
journal, January 2013
- Wang, Sheng-Bing; Murray, Christopher I.; Chung, Heaseung S.
- Trends in Cardiovascular Medicine, Vol. 23, Issue 1
14-3-3gamma Interacts with and Is Phosphorylated by Multiple Protein Kinase C Isoforms in PDGF-Stimulated Human Vascular Smooth Muscle Cells
journal, July 1999
- Autieri, Michael V.; Carbone, Christopher J.
- DNA and Cell Biology, Vol. 18, Issue 7
Unlocking the code of 14-3-3
journal, April 2004
- Dougherty, Michele K.; Morrison, Deborah K.
- Journal of Cell Science, Vol. 117, Issue 10
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
journal, February 2011
- Son, Yong; Cheong, Yong-Kwan; Kim, Nam-Ho
- Journal of Signal Transduction, Vol. 2011
Organization of Iron-Sulfur Clusters in Respiratory Complex I
journal, July 2005
- Hinchliffe, P.
- Science, Vol. 309, Issue 5735
Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines
journal, January 2017
- Duan, Jicheng; Gaffrey, Matthew J.; Qian, Wei-Jun
- Molecular BioSystems, Vol. 13, Issue 5
Redox Biology: Computational Approaches to the Investigation of Functional Cysteine Residues
journal, July 2011
- Marino, Stefano M.; Gladyshev, Vadim N.
- Antioxidants & Redox Signaling, Vol. 15, Issue 1
Works referencing / citing this record:
Increase in muscle power is associated with myofibrillar ATPase adaptations during resistance training
journal, May 2019
- Philippe, Antony G.; Lionne, Corinne; Sanchez, Anthony M. J.
- Experimental Physiology, Vol. 104, Issue 8
Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease
journal, November 2018
- Gómez-Serrano, María; Camafeita, Emilio; Loureiro, Marta
- Oxidative Medicine and Cellular Longevity, Vol. 2018
Isotopically Labeled Clickable Glutathione to Quantify Protein S‐Glutathionylation
journal, October 2019
- VanHecke, Garrett C.; Yapa Abeywardana, Maheeshi; Huang, Bo
- ChemBioChem, Vol. 21, Issue 6
Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2
journal, July 2019
- Mallay, Sarah; Gill, Robert; Young, Adrian
- Antioxidants, Vol. 8, Issue 8
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.