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Title: Gold nanoparticles for cancer theranostics — A brief update

Abstract

Gold nanoparticles (AuNPs) exhibit superior optical and physical properties for more effective treatment of cancer through incorporating both diagnostic and therapeutic functions into one single platform. The ability to passively accumulate on tumor cells provides AuNPs the opportunity to become an attractive contrast agent for X-ray based computed tomography (CT) imaging in vivo. Because of facile surface modification, various size and shape of AuNPs have been extensively functionalized and applied as active nanoprobes and drug carriers for cancer targeted theranostics. Moreover, their capabilities on producing photoacoustic (PA) signals and photothermal effects have been used to image and treat tumor progression, respectively. Furthermore, we review the developments of AuNPs as cancer diagnostics and chemotherapeutic drug vector, summarizing strategies for tumor targeting and their applications in vitro and in vivo.

Authors:
 [1];  [1];  [2];  [1]
  1. Northeastern Univ., Liaoning (People's Republic of China)
  2. Northeastern Univ., Liaoning (People's Republic of China); Stanford Univ., Stanford, CA (United States)
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1437935
Grant/Contract Number:  
SC0008397
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Innovative Optical Health Sciences
Additional Journal Information:
Journal Volume: 9; Journal Issue: 4; Journal ID: ISSN 1793-5458
Publisher:
World Scientific
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Gold nanoparticles; multimodal imaging; phototherapy; gene therapy; drug delivery

Citation Formats

Zhao, Ning, Pan, Yongxu, Cheng, Zhen, and Liu, Hongguang. Gold nanoparticles for cancer theranostics — A brief update. United States: N. p., 2016. Web. doi:10.1142/S1793545816300044.
Zhao, Ning, Pan, Yongxu, Cheng, Zhen, & Liu, Hongguang. Gold nanoparticles for cancer theranostics — A brief update. United States. doi:10.1142/S1793545816300044.
Zhao, Ning, Pan, Yongxu, Cheng, Zhen, and Liu, Hongguang. Fri . "Gold nanoparticles for cancer theranostics — A brief update". United States. doi:10.1142/S1793545816300044. https://www.osti.gov/servlets/purl/1437935.
@article{osti_1437935,
title = {Gold nanoparticles for cancer theranostics — A brief update},
author = {Zhao, Ning and Pan, Yongxu and Cheng, Zhen and Liu, Hongguang},
abstractNote = {Gold nanoparticles (AuNPs) exhibit superior optical and physical properties for more effective treatment of cancer through incorporating both diagnostic and therapeutic functions into one single platform. The ability to passively accumulate on tumor cells provides AuNPs the opportunity to become an attractive contrast agent for X-ray based computed tomography (CT) imaging in vivo. Because of facile surface modification, various size and shape of AuNPs have been extensively functionalized and applied as active nanoprobes and drug carriers for cancer targeted theranostics. Moreover, their capabilities on producing photoacoustic (PA) signals and photothermal effects have been used to image and treat tumor progression, respectively. Furthermore, we review the developments of AuNPs as cancer diagnostics and chemotherapeutic drug vector, summarizing strategies for tumor targeting and their applications in vitro and in vivo.},
doi = {10.1142/S1793545816300044},
journal = {Journal of Innovative Optical Health Sciences},
number = 4,
volume = 9,
place = {United States},
year = {2016},
month = {3}
}

Journal Article:
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