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Title: Leveraging algal omics to reveal potential targets for augmenting TAG accumulation

Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. Here, this review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ; ORCiD logo [2]
  1. Indian Institute of Technology Roorkee, Uttarakhand (India)
  2. National Renewable Energy Lab. (NREL), Golden, CO (United States)
Publication Date:
Report Number(s):
NREL/JA-5100-71479
Journal ID: ISSN 0734-9750
Grant/Contract Number:
AC36-08GO28308
Type:
Published Article
Journal Name:
Biotechnology Advances
Additional Journal Information:
Journal Volume: 36; Journal Issue: 4; Journal ID: ISSN 0734-9750
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org:
USDOE Office of Energy Efficiency and Renewable Energy (EERE)
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; algal; omics; triacylglycerol; transcriptomics; proteomics; metabolomic
OSTI Identifier:
1437870
Alternate Identifier(s):
OSTI ID: 1436401