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Title: Hydrodynamic coupling of particle inclusions embedded in curved lipid bilayer membranes

Here, we develop theory and computational methods to investigate particle inclusions embedded within curved lipid bilayer membranes. We consider the case of spherical lipid vesicles where inclusion particles are coupled through (i) intramembrane hydrodynamics, (ii) traction stresses with the external and trapped solvent fluid, and (iii) intermonolayer slip between the two leaflets of the bilayer. We investigate relative to flat membranes how the membrane curvature and topology augment hydrodynamic responses. We show how both the translational and rotational mobility of protein inclusions are effected by the membrane curvature, ratio of intramembrane viscosity to solvent viscosity, and intermonolayer slip. For general investigations of many-particle dynamics, we also discuss how our approaches can be used to treat the collective diffusion and hydrodynamic coupling within spherical bilayers.
Authors:
 [1] ;  [1]
  1. Univ. of California, Santa Barbara, CA (United States)
Publication Date:
Grant/Contract Number:
SC0009254
Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 12; Journal Issue: 32; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Research Org:
Univ. of California, Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE
OSTI Identifier:
1437262

Sigurdsson, Jon Karl, and Atzberger, Paul J. Hydrodynamic coupling of particle inclusions embedded in curved lipid bilayer membranes. United States: N. p., Web. doi:10.1039/c6sm00194g.
Sigurdsson, Jon Karl, & Atzberger, Paul J. Hydrodynamic coupling of particle inclusions embedded in curved lipid bilayer membranes. United States. doi:10.1039/c6sm00194g.
Sigurdsson, Jon Karl, and Atzberger, Paul J. 2016. "Hydrodynamic coupling of particle inclusions embedded in curved lipid bilayer membranes". United States. doi:10.1039/c6sm00194g. https://www.osti.gov/servlets/purl/1437262.
@article{osti_1437262,
title = {Hydrodynamic coupling of particle inclusions embedded in curved lipid bilayer membranes},
author = {Sigurdsson, Jon Karl and Atzberger, Paul J.},
abstractNote = {Here, we develop theory and computational methods to investigate particle inclusions embedded within curved lipid bilayer membranes. We consider the case of spherical lipid vesicles where inclusion particles are coupled through (i) intramembrane hydrodynamics, (ii) traction stresses with the external and trapped solvent fluid, and (iii) intermonolayer slip between the two leaflets of the bilayer. We investigate relative to flat membranes how the membrane curvature and topology augment hydrodynamic responses. We show how both the translational and rotational mobility of protein inclusions are effected by the membrane curvature, ratio of intramembrane viscosity to solvent viscosity, and intermonolayer slip. For general investigations of many-particle dynamics, we also discuss how our approaches can be used to treat the collective diffusion and hydrodynamic coupling within spherical bilayers.},
doi = {10.1039/c6sm00194g},
journal = {Soft Matter},
number = 32,
volume = 12,
place = {United States},
year = {2016},
month = {6}
}