Extracellular matrix in lung development, homeostasis and disease

doi:10.1016/j.matbio.2018.03.005

Title: Extracellular matrix in lung development, homeostasis and disease

Abstract

Here, the lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

Authors:

Zhou, Yong ^[1]; Horowitz, Jeffrey C. ^[2];

^[3];

^[4]; Atabai, Kamran ^[5];

^[6];

^[7]; Corley, Richard A. ^[8]; Ding, Bi -Sen ^[9];

^[10]; Hansen, Kirk C. ^[11]; Hagood, James S. ^[12]; Kheradmand, Farrah ^[13]; Lin, Qing S. ^[14]; Neptune, Enid ^[15];

^[6];

^[16]; Parks, William C. ^[17]; Tschumperlin, Daniel J. ^[18];

^[2] more »

Univ. of Alabama, Birmingham, AL (United States). Division of Pulmonary, Allergy and Critical Care Medicine
Univ. of Michigan, Ann Arbor, MI (United States). Division of Pulmonary and Critical Care Medicine
Univ. of Illinois, Chicago, IL (United States). Dept. of Physiology & Biophysics
Univ. of Alabama, Birmingham, AL (United States). Dept. of Pediatrics
Univ. of California, San Francisco, CA (United States). Lung Biology Center
Yale Univ., New Haven, CT (United States). Dept. of Anesthesiology
Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Medicine
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Systems Toxicology & Exposure Science
Cornell Univ., Ithaca, NY (United States). Weill Cornell Medical College
Univ. of California, San Diego, CA (United States). Sanford Consortium for Regenerative Medicine
Univ. of Colorado, Denver, CO (United States). Biochemistry & Molecular Genetics
Univ. of California, San Diego, CA (United States). Pediatric Respiratory Medicine
Baylor College of Medicine, Houston, TX (United States). Division of Pulmonary and Critical Care
National Heart, Lung, and Blood Inst., Bethesda, MD (United States). Division of Lung Diseases
Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine. Division of Pulmonary and Critical Care Medicine
Univ. of Pittsburgh, PA (United States). Division of Environmental and Occupational Health
Cedars-Sinai Medical Center, Los Angeles, CA (United States). Dept. of Medicine
Mayo Clinic College of Medicine, Rochester, MN (United States). Dept. of Physiology & Biomedical Engineering
Univ. of California, San Francisco, CA (United States). Division of Pulmonary and Critical Care Medicine

Publication Date:: 2018-03-08

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1437148

Grant/Contract Number:: AC05-76RL01830

Resource Type:: Accepted Manuscript

Journal Name:: Matrix Biology

Additional Journal Information:: Journal Volume: 73; Journal ID: ISSN 0945-053X

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., and Thannickal, Victor J. Extracellular matrix in lung development, homeostasis and disease.  United States: N. p., 2018. 
        Web.  doi:10.1016/j.matbio.2018.03.005.

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                    Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., & Thannickal, Victor J. Extracellular matrix in lung development, homeostasis and disease.  United States.  doi:10.1016/j.matbio.2018.03.005.

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                    Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., and Thannickal, Victor J. Thu .  
        "Extracellular matrix in lung development, homeostasis and disease".  United States.  doi:10.1016/j.matbio.2018.03.005.  https://www.osti.gov/servlets/purl/1437148.

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@article{osti_1437148,

  title        = {Extracellular matrix in lung development, homeostasis and disease},

  author       = {Zhou, Yong and Horowitz, Jeffrey C. and Naba, Alexandra and Ambalavanan, Namasivayam and Atabai, Kamran and Balestrini, Jenna and Bitterman, Peter B. and Corley, Richard A. and Ding, Bi -Sen and Engler, Adam J. and Hansen, Kirk C. and Hagood, James S. and Kheradmand, Farrah and Lin, Qing S. and Neptune, Enid and Niklason, Laura and Ortiz, Luis A. and Parks, William C. and Tschumperlin, Daniel J. and White, Eric S. and Chapman, Harold A. and Thannickal, Victor J.},

  abstractNote = {Here, the lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.},

  doi          = {10.1016/j.matbio.2018.03.005},

  journal      = {Matrix Biology},

  number       = ,

  volume       = 73,

  place        = {United States},

  year         = {2018},

  month        = {3}

}

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DOI: 10.1016/j.matbio.2018.03.005

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Cited by: 11 works

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Figures / Tables:

Figure 1: Role of the ECM in lung homeostasis and disease. N and the maintenance of lung homeostasis in adulthood. Abe composition, biomechanics, dynamics and topography, are ch including IPF, COPD and BPD. IPF = idiopathic pulmonary f BPD = bronchopulmonary dysplasia.

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