Extracellular matrix in lung development, homeostasis and disease
Abstract
Here, the lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.
- Authors:
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- Univ. of Alabama, Birmingham, AL (United States). Division of Pulmonary, Allergy and Critical Care Medicine
- Univ. of Michigan, Ann Arbor, MI (United States). Division of Pulmonary and Critical Care Medicine
- Univ. of Illinois, Chicago, IL (United States). Dept. of Physiology & Biophysics
- Univ. of Alabama, Birmingham, AL (United States). Dept. of Pediatrics
- Univ. of California, San Francisco, CA (United States). Lung Biology Center
- Yale Univ., New Haven, CT (United States). Dept. of Anesthesiology
- Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Medicine
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Systems Toxicology & Exposure Science
- Cornell Univ., Ithaca, NY (United States). Weill Cornell Medical College
- Univ. of California, San Diego, CA (United States). Sanford Consortium for Regenerative Medicine
- Univ. of Colorado, Denver, CO (United States). Biochemistry & Molecular Genetics
- Univ. of California, San Diego, CA (United States). Pediatric Respiratory Medicine
- Baylor College of Medicine, Houston, TX (United States). Division of Pulmonary and Critical Care
- National Heart, Lung, and Blood Inst., Bethesda, MD (United States). Division of Lung Diseases
- Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine. Division of Pulmonary and Critical Care Medicine
- Univ. of Pittsburgh, PA (United States). Division of Environmental and Occupational Health
- Cedars-Sinai Medical Center, Los Angeles, CA (United States). Dept. of Medicine
- Mayo Clinic College of Medicine, Rochester, MN (United States). Dept. of Physiology & Biomedical Engineering
- Univ. of California, San Francisco, CA (United States). Division of Pulmonary and Critical Care Medicine
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1437148
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Matrix Biology
- Additional Journal Information:
- Journal Volume: 73; Journal ID: ISSN 0945-053X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., and Thannickal, Victor J. Extracellular matrix in lung development, homeostasis and disease. United States: N. p., 2018.
Web. doi:10.1016/j.matbio.2018.03.005.
Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., & Thannickal, Victor J. Extracellular matrix in lung development, homeostasis and disease. United States. https://doi.org/10.1016/j.matbio.2018.03.005
Zhou, Yong, Horowitz, Jeffrey C., Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B., Corley, Richard A., Ding, Bi -Sen, Engler, Adam J., Hansen, Kirk C., Hagood, James S., Kheradmand, Farrah, Lin, Qing S., Neptune, Enid, Niklason, Laura, Ortiz, Luis A., Parks, William C., Tschumperlin, Daniel J., White, Eric S., Chapman, Harold A., and Thannickal, Victor J. Thu .
"Extracellular matrix in lung development, homeostasis and disease". United States. https://doi.org/10.1016/j.matbio.2018.03.005. https://www.osti.gov/servlets/purl/1437148.
@article{osti_1437148,
title = {Extracellular matrix in lung development, homeostasis and disease},
author = {Zhou, Yong and Horowitz, Jeffrey C. and Naba, Alexandra and Ambalavanan, Namasivayam and Atabai, Kamran and Balestrini, Jenna and Bitterman, Peter B. and Corley, Richard A. and Ding, Bi -Sen and Engler, Adam J. and Hansen, Kirk C. and Hagood, James S. and Kheradmand, Farrah and Lin, Qing S. and Neptune, Enid and Niklason, Laura and Ortiz, Luis A. and Parks, William C. and Tschumperlin, Daniel J. and White, Eric S. and Chapman, Harold A. and Thannickal, Victor J.},
abstractNote = {Here, the lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.},
doi = {10.1016/j.matbio.2018.03.005},
journal = {Matrix Biology},
number = ,
volume = 73,
place = {United States},
year = {Thu Mar 08 00:00:00 EST 2018},
month = {Thu Mar 08 00:00:00 EST 2018}
}
Web of Science
Figures / Tables:
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