Impact of spatial organization on a novel auxotrophic interaction among soil microbes
Abstract
Here, a key prerequisite to achieve a deeper understanding of microbial communities and to engineer synthetic ones is to identify the individual metabolic interactions among key species and how these interactions are affected by different environmental factors. Deciphering the physiological basis of species–species and species–environment interactions in spatially organized environments requires reductionist approaches using ecologically and functionally relevant species. To this end, we focus here on a defined system to study the metabolic interactions in a spatial context among the plant-beneficial endophytic fungus Serendipita indica, and the soil-dwelling model bacterium Bacillus subtilis. Focusing on the growth dynamics of S. indica under defined conditions, we identified an auxotrophy in this organism for thiamine, which is a key co-factor for essential reactions in the central carbon metabolism. We found that S. indica growth is restored in thiamine-free media, when co-cultured with B. subtilis. The success of this auxotrophic interaction, however, was dependent on the spatial and temporal organization of the system; the beneficial impact of B. subtilis was only visible when its inoculation was separated from that of S. indica either in time or space. These findings describe a key auxotrophic interaction in the soil among organisms that are shown to bemore »
- Authors:
-
[2];
[1]
- The Univ. of Warwick, Coventry (United Kingdom)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1434433
- Report Number(s):
- LA-UR-18-21554
Journal ID: ISSN 1751-7362
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- The ISME Journal
- Additional Journal Information:
- Journal Volume: 12; Journal ID: ISSN 1751-7362
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Biological Science; Auxotrophy; soil microbial communities; Serendipita indica; Bacillus subtilis; endophytic fungi; thiamine; vitamins; metabolic interaction; precision farming
Citation Formats
Jiang, Xue, ZerfaB, Christian, Feng, Song, Eichmann, Ruth, Asally, Munehiro, Schafer, Patrick, and Soyer, Orkun S. Impact of spatial organization on a novel auxotrophic interaction among soil microbes. United States: N. p., 2018.
Web. doi:10.1038/s41396-018-0095-z.
Jiang, Xue, ZerfaB, Christian, Feng, Song, Eichmann, Ruth, Asally, Munehiro, Schafer, Patrick, & Soyer, Orkun S. Impact of spatial organization on a novel auxotrophic interaction among soil microbes. United States. https://doi.org/10.1038/s41396-018-0095-z
Jiang, Xue, ZerfaB, Christian, Feng, Song, Eichmann, Ruth, Asally, Munehiro, Schafer, Patrick, and Soyer, Orkun S. Fri .
"Impact of spatial organization on a novel auxotrophic interaction among soil microbes". United States. https://doi.org/10.1038/s41396-018-0095-z. https://www.osti.gov/servlets/purl/1434433.
@article{osti_1434433,
title = {Impact of spatial organization on a novel auxotrophic interaction among soil microbes},
author = {Jiang, Xue and ZerfaB, Christian and Feng, Song and Eichmann, Ruth and Asally, Munehiro and Schafer, Patrick and Soyer, Orkun S.},
abstractNote = {Here, a key prerequisite to achieve a deeper understanding of microbial communities and to engineer synthetic ones is to identify the individual metabolic interactions among key species and how these interactions are affected by different environmental factors. Deciphering the physiological basis of species–species and species–environment interactions in spatially organized environments requires reductionist approaches using ecologically and functionally relevant species. To this end, we focus here on a defined system to study the metabolic interactions in a spatial context among the plant-beneficial endophytic fungus Serendipita indica, and the soil-dwelling model bacterium Bacillus subtilis. Focusing on the growth dynamics of S. indica under defined conditions, we identified an auxotrophy in this organism for thiamine, which is a key co-factor for essential reactions in the central carbon metabolism. We found that S. indica growth is restored in thiamine-free media, when co-cultured with B. subtilis. The success of this auxotrophic interaction, however, was dependent on the spatial and temporal organization of the system; the beneficial impact of B. subtilis was only visible when its inoculation was separated from that of S. indica either in time or space. These findings describe a key auxotrophic interaction in the soil among organisms that are shown to be important for plant ecosystem functioning, and point to the potential importance of spatial and temporal organization for the success of auxotrophic interactions. These points can be particularly important for engineering of minimal functional synthetic communities as plant seed treatments and for vertical farming under defined conditions.},
doi = {10.1038/s41396-018-0095-z},
journal = {The ISME Journal},
number = ,
volume = 12,
place = {United States},
year = {2018},
month = {3}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 30 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Interactions between mycorrhizal fungi and other soil organisms
journal, February 1994
- Fitter, A. H.; Garbaye, J.
- Plant and Soil, Vol. 159, Issue 1
Networks of energetic and metabolic interactions define dynamics in microbial communities
journal, November 2015
- Embree, Mallory; Liu, Joanne K.; Al-Bassam, Mahmoud M.
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 50
A cell wall extract from the endophytic fungus Piriformospora indica promotes growth of Arabidopsis seedlings and induces intracellular calcium elevation in roots
journal, July 2009
- Vadassery, Jyothilakshmi; Ranf, Stefanie; Drzewiecki, Corinna
- The Plant Journal, Vol. 59, Issue 2
Competition for vitamin B 1 (thiamin) structures numerous ecological interactions
journal, June 2017
- Kraft, Clifford E.; Angert, Esther R.
- The Quarterly Review of Biology, Vol. 92, Issue 2
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
journal, March 2010
- Guindon, Stéphane; Dufayard, Jean-François; Lefort, Vincent
- Systematic Biology, Vol. 59, Issue 3
Niche engineering demonstrates a latent capacity for fungal-algal mutualism
journal, July 2014
- Hom, Erik F. Y.; Murray, Andrew W.
- Science, Vol. 345, Issue 6192
A new thiamin salvage pathway
journal, July 2007
- Jenkins, Amy Haas; Schyns, Ghislain; Potot, Sébastien
- Nature Chemical Biology, Vol. 3, Issue 8
The Role of B Vitamins in Marine Biogeochemistry
journal, January 2014
- Sañudo-Wilhelmy, Sergio A.; Gómez-Consarnau, Laura; Suffridge, Christopher
- Annual Review of Marine Science, Vol. 6, Issue 1
Thiamin biosynthesis in prokaryotes
journal, April 1999
- Begley, T. P.; Downs, Diana M.; Ealick, Steven E.
- Archives of Microbiology, Vol. 171, Issue 5
KEGG: Kyoto Encyclopedia of Genes and Genomes
journal, January 2000
- Kanehisa, Minoru; Goto, Susumu
- Nucleic Acids Research, Vol. 28, Issue 1, p. 27-30
Self-organized patchiness facilitates survival in a cooperatively growing Bacillus subtilis population
journal, March 2016
- Ratzke, Christoph; Gore, Jeff
- Nature Microbiology, Vol. 1, Issue 5
Metabolic origins of spatial organization in the tumor microenvironment
journal, February 2017
- Carmona-Fontaine, Carlos; Deforet, Maxime; Akkari, Leila
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 11
The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss
journal, March 2012
- Morris, J. Jeffrey; Lenski, Richard E.; Zinser, Erik R.
- mBio, Vol. 3, Issue 2
The Soil-Borne Supremacy
journal, March 2016
- Pieterse, Corné M. J.; de Jonge, Ronnie; Berendsen, Roeland L.
- Trends in Plant Science, Vol. 21, Issue 3
The relationship between thiamine and two symbioses: Root nodule symbiosis and arbuscular mycorrhiza
journal, October 2016
- Nagae, Miwa; Parniske, Martin; Kawaguchi, Masayoshi
- Plant Signaling & Behavior, Vol. 11, Issue 12
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
journal, September 1997
- Altschul, Stephen F.; Madden, Thomas L.; Schäffer, Alejandro A.
- Nucleic Acids Research, Vol. 25, Issue 17, p. 3389-3402
Impact of plant domestication on rhizosphere microbiome assembly and functions
journal, June 2015
- Pérez-Jaramillo, Juan E.; Mendes, Rodrigo; Raaijmakers, Jos M.
- Plant Molecular Biology, Vol. 90, Issue 6
Engineering microbial consortia for controllable outputs
journal, March 2016
- Lindemann, Stephen R.; Bernstein, Hans C.; Song, Hyun-Seob
- The ISME Journal, Vol. 10, Issue 9
Piriformospora indica-a mutualistic basidiomycete with an exceptionally large plant host range: Mutualistic root symbiosis
journal, November 2011
- Qiang, Xiaoyu; Weiss, Michael; Kogel, Karl-Heinz
- Molecular Plant Pathology, Vol. 13, Issue 5
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
journal, October 2011
- Chatterjee, Abhishek; Abeydeera, N. Dinuka; Bale, Shridhar
- Nature, Vol. 478, Issue 7370
Engineering ecosystems and synthetic ecologies
journal, January 2012
- Mee, Michael T.; Wang, Harris H.
- Molecular BioSystems, Vol. 8, Issue 10
Decoding molecular interactions in microbial communities
journal, July 2016
- Abreu, Nicole A.; Taga, Michiko E.
- FEMS Microbiology Reviews, Vol. 40, Issue 5
Underlying mechanisms for syntrophic metabolism of essential enzyme cofactors in microbial communities
journal, February 2017
- Romine, Margaret F.; Rodionov, Dmitry A.; Maezato, Yukari
- The ISME Journal, Vol. 11, Issue 6
Biotin and Other Water-Soluble Vitamins Are Key Growth Factors for Alfalfa Root Colonization by Rhizobium meliioti 1021
journal, January 1996
- Streit, Wolfgang R.
- Molecular Plant-Microbe Interactions, Vol. 9, Issue 5
Applications of free living plant growth-promoting rhizobacteria
journal, August 2004
- Lucy, M.; Reed, E.; R. Glick, Bernard
- Antonie van Leeuwenhoek, Vol. 86, Issue 1
Strong inter-population cooperation leads to partner intermixing in microbial communities
journal, January 2013
- Momeni, Babak; Brileya, Kristen A.; Fields, Matthew W.
- eLife, Vol. 2
Temporal and spatial constraints on community assembly during microbial colonization of wood in seawater
journal, April 2015
- Kalenitchenko, Dimitri; Fagervold, Sonja K.; Pruski, Audrey M.
- The ISME Journal, Vol. 9, Issue 12
Taking the Fungal Highway: Mobilization of Pollutant-Degrading Bacteria by Fungi
journal, June 2005
- Kohlmeier, Stefanie; Smits, Theo H. M.; Ford, Roseanne M.
- Environmental Science & Technology, Vol. 39, Issue 12
Syntrophic exchange in synthetic microbial communities
journal, April 2014
- Mee, M. T.; Collins, J. J.; Church, G. M.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 20
The NCBI Taxonomy database
journal, December 2011
- Federhen, S.
- Nucleic Acids Research, Vol. 40, Issue D1
Genomic distribution of B-vitamin auxotrophy and uptake transporters in environmental bacteria from the C hloroflexi phylum : B-vitamin biosynthesis and transport in
journal, December 2014
- Rodionova, Irina A.; Li, Xiaoqing; Plymale, Andrew E.
- Environmental Microbiology Reports, Vol. 7, Issue 2
Sebacinales – one thousand and one interactions with land plants
journal, February 2016
- Weiß, Michael; Waller, Frank; Zuccaro, Alga
- New Phytologist, Vol. 211, Issue 1
Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities
journal, August 2005
- Haas, Amy L.; Laun, Nathan P.; Begley, Tadhg P.
- Bioorganic Chemistry, Vol. 33, Issue 4
Metabolic evolution and the self-organization of ecosystems
journal, March 2017
- Braakman, Rogier; Follows, Michael J.; Chisholm, Sallie W.
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 15
Insights into the Evolution of Vitamin B12 Auxotrophy from Sequenced Algal Genomes
journal, May 2011
- Helliwell, K. E.; Wheeler, G. L.; Leptos, K. C.
- Molecular Biology and Evolution, Vol. 28, Issue 10
A Phosphate Transporter from the Root Endophytic Fungus Piriformospora indica Plays a Role in Phosphate Transport to the Host Plant
journal, May 2010
- Yadav, Vikas; Kumar, Manoj; Deep, Deepak Kumar
- Journal of Biological Chemistry, Vol. 285, Issue 34
Fungal—bacterial interactions: a mixed bag of mingling microbes
journal, August 2006
- Wargo, Matthew J.; Hogan, Deborah A.
- Current Opinion in Microbiology, Vol. 9, Issue 4
Bacterial associations with mycorrhizal fungi: Close and distant friends in the rhizosphere
journal, December 1997
- Perotto, Silvia; Bonfante, Paola
- Trends in Microbiology, Vol. 5, Issue 12
Oxygen Profiles in, and in the Agar Beneath, Colonies of Bacillus Cereus, Staphylococcus Albus and Escherichia Coli
journal, May 1987
- Peters, A. C.; Wimpenny, J. W. T.; Coombs, J. P.
- Microbiology, Vol. 133, Issue 5
Fiji: an open-source platform for biological-image analysis
journal, June 2012
- Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin
- Nature Methods, Vol. 9, Issue 7
Isolation and Characterization of New Thiamine-Deregulated Mutants of Bacillus subtilis
journal, November 2005
- Schyns, G.; Potot, S.; Geng, Y.
- Journal of Bacteriology, Vol. 187, Issue 23
SubtiWiki--a comprehensive community resource for the model organism Bacillus subtilis
journal, November 2011
- Mader, U.; Schmeisky, A. G.; Florez, L. A.
- Nucleic Acids Research, Vol. 40, Issue D1
Morphological optimization for access to dual oxidants in biofilms
journal, December 2013
- Kempes, C. P.; Okegbe, C.; Mears-Clarke, Z.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 1
MUSCLE: multiple sequence alignment with high accuracy and high throughput
journal, March 2004
- Edgar, R. C.
- Nucleic Acids Research, Vol. 32, Issue 5, p. 1792-1797
High-density spore production of Piriformospora indica, a plant growth-promoting endophyte, by optimization of nutritional and cultural parameters
journal, February 2011
- Kumar, Vinod; Sahai, Vikram; Bisaria, V. S.
- Bioresource Technology, Vol. 102, Issue 3
Structure and Functions of the Bacterial Microbiota of Plants
journal, April 2013
- Bulgarelli, Davide; Schlaeppi, Klaus; Spaepen, Stijn
- Annual Review of Plant Biology, Vol. 64, Issue 1
Widespread decay of vitamin-related pathways: coincidence or consequence?
journal, August 2013
- Helliwell, Katherine E.; Wheeler, Glen L.; Smith, Alison G.
- Trends in Genetics, Vol. 29, Issue 8
Bacterial Community Morphogenesis Is Intimately Linked to the Intracellular Redox State
journal, January 2013
- Dietrich, L. E. P.; Okegbe, C.; Price-Whelan, A.
- Journal of Bacteriology, Vol. 195, Issue 7
The Root-Colonizing Endophyte Pirifomospora indica Confers Drought Tolerance in Arabidopsis by Stimulating the Expression of Drought Stress–Related Genes in Leaves
journal, June 2008
- Sherameti, Irena; Tripathi, Swati; Varma, Ajit
- Molecular Plant-Microbe Interactions, Vol. 21, Issue 6
Sinorhizobium meliloti Flavin Secretion and Bacteria-Host Interaction: Role of the Bifunctional RibBA Protein
journal, May 2014
- Yurgel, Svetlana N.; Rice, Jennifer; Domreis, Elizabeth
- Molecular Plant-Microbe Interactions, Vol. 27, Issue 5
Better together: engineering and application of microbial symbioses
journal, December 2015
- Hays, Stephanie G.; Patrick, William G.; Ziesack, Marika
- Current Opinion in Biotechnology, Vol. 36
Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance
journal, October 1997
- Machado, Carlos R.; Praekelt, Uta M.; de Oliveira, Regina Costa
- Journal of Molecular Biology, Vol. 273, Issue 1
Rapid HPLC Measurement of Thiamine and Its Phosphate Esters in Whole Blood
journal, March 2008
- Lu, J.; Frank, E. L.
- Clinical Chemistry, Vol. 54, Issue 5
Spore germination and hyphal growth of a vesicular–arbuscular mycorrhizal fungus, Glomus mosseae (Gerdemann and Trappe), under decreased oxygen and increased carbon dioxide concentrations
journal, October 1983
- Tacon, F. Le; Skinner, F. A.; Mosse, Barbara
- Canadian Journal of Microbiology, Vol. 29, Issue 10
Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of the Mutualistic Root Symbiont Piriformospora indica
journal, October 2011
- Zuccaro, Alga; Lahrmann, Urs; Güldener, Ulrich
- PLoS Pathogens, Vol. 7, Issue 10
Metabolic modelling in a dynamic evolutionary framework predicts adaptive diversification of bacteria in a long-term evolution experiment
journal, August 2016
- Großkopf, Tobias; Consuegra, Jessika; Gaffé, Joël
- BMC Evolutionary Biology, Vol. 16, Issue 1
Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow
journal, October 2017
- Ponomarova, Olga; Gabrielli, Natalia; Sévin, Daniel C.
- Cell Systems, Vol. 5, Issue 4
Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation
journal, June 1998
- Hohmann, Stefan; Meacock, Peter A.
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1385, Issue 2
Plant and microbial strategies to improve the phosphorus efficiency of agriculture
journal, September 2011
- Richardson, Alan E.; Lynch, Jonathan P.; Ryan, Peter R.
- Plant and Soil, Vol. 349, Issue 1-2
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
journal, November 2012
- Quast, Christian; Pruesse, Elmar; Yilmaz, Pelin
- Nucleic Acids Research, Vol. 41, Issue D1
Broad-Spectrum Suppression of Innate Immunity Is Required for Colonization of Arabidopsis Roots by the Fungus Piriformospora indica
journal, April 2011
- Jacobs, Sophie; Zechmann, Bernd; Molitor, Alexandra
- Plant Physiology, Vol. 156, Issue 2
MELISSA: a loop of interconnected bioreactors to develop life support in Space
journal, November 2002
- Gòdia, F.; Albiol, J.; Montesinos, J. L.
- Journal of Biotechnology, Vol. 99, Issue 3
Synthetic microbial communities
journal, April 2014
- Großkopf, Tobias; Soyer, Orkun S.
- Current Opinion in Microbiology, Vol. 18
Proline auxotrophy in Sinorhizobium meliloti results in a plant-specific symbiotic phenotype
journal, December 2015
- Zamani, Maryam; Finan, Turlough M.; Cowie, Alison
- Microbiology, Vol. 161, Issue 12
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine
journal, June 2003
- Wightman, R.
- Microbiology, Vol. 149, Issue 6
Engineering microbial communities using thermodynamic principles and electrical interfaces
journal, April 2018
- Zerfaß, Christian; Chen, Jing; Soyer, Orkun S.
- Current Opinion in Biotechnology, Vol. 50
Challenges in microbial ecology: building predictive understanding of community function and dynamics
journal, March 2016
- Widder, Stefanie; Allen, Rosalind J.; Pfeiffer, Thomas
- The ISME Journal, Vol. 10, Issue 11
Piriformospora indica promotes adventitious root formation in cuttings
journal, May 2007
- Druege, Uwe; Baltruschat, Helmut; Franken, Philipp
- Scientia Horticulturae, Vol. 112, Issue 4
Arbuscular mycorrhiza and soil nitrogen cycling
journal, March 2012
- Veresoglou, Stavros D.; Chen, Baodong; Rillig, Matthias C.
- Soil Biology and Biochemistry, Vol. 46
Bacillus subtilis isolated from the human gastrointestinal tract
journal, March 2009
- Hong, Huynh A.; Khaneja, Reena; Tam, Nguyen M. K.
- Research in Microbiology, Vol. 160, Issue 2
Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community
journal, July 2016
- Campbell, Kate; Vowinckel, Jakob; Ralser, Markus
- Biotechnology Journal, Vol. 11, Issue 9
Plant root-microbe communication in shaping root microbiomes
journal, January 2016
- Lareen, Andrew; Burton, Frances; Schäfer, Patrick
- Plant Molecular Biology, Vol. 90, Issue 6
Environmental pH modulation by pathogenic fungi as a strategy to conquer the host
journal, February 2017
- Vylkova, Slavena
- PLOS Pathogens, Vol. 13, Issue 2
The Structural and Biochemical Foundations of Thiamin Biosynthesis
journal, June 2009
- Jurgenson, Christopher T.; Begley, Tadhg P.; Ealick, Steven E.
- Annual Review of Biochemistry, Vol. 78, Issue 1
Factors Relating to Peanut Yield Increases After Seed Treatment with Bacillus subtilis
journal, January 1991
- Turner, J. T.
- Plant Disease, Vol. 75, Issue 4
The endophytic fungus Piriformospora indica reprograms barley to salt-stress tolerance, disease resistance, and higher yield
journal, September 2005
- Waller, F.; Achatz, B.; Baltruschat, H.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 38
The Microbial Engines That Drive Earth's Biogeochemical Cycles
journal, May 2008
- Falkowski, P. G.; Fenchel, T.; Delong, E. F.
- Science, Vol. 320, Issue 5879
Genetic drift opposes mutualism during spatial population expansion
journal, January 2014
- Muller, M. J. I.; Neugeboren, B. I.; Nelson, D. R.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 3
Fitness and stability of obligate cross-feeding interactions that emerge upon gene loss in bacteria
journal, November 2013
- Pande, Samay; Merker, Holger; Bohl, Katrin
- The ISME Journal, Vol. 8, Issue 5
Energetics of syntrophic cooperation in methanogenic degradation.
journal, January 1997
- Schink, B.
- Microbiology and molecular biology reviews : MMBR, Vol. 61, Issue 2
Studies on Lysogenesis i.
journal, January 1951
- Bertani, G.
- Journal of Bacteriology, Vol. 62, Issue 3
Serendipita restingae sp. nov. (Sebacinales): an orchid mycorrhizal agaricomycete with wide host range
journal, November 2020
- Fritsche, Yohan; Lopes, Morgana E.; Selosse, Marc-André
- Mycorrhiza, Vol. 31, Issue 1
Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula
journal, June 2020
- Roggero, Paola; Liotto, Nadia; Pozzi, Chiara
- Nature Communications, Vol. 11, Issue 1
Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community
text, January 2016
- Campbell, Kate; Vowinckel, Jakob; Ralser, Markus
- Apollo - University of Cambridge Repository
Challenges in microbial ecology: Building predictive understanding of community function and dynamics
text, January 2016
- Unknown, (:Unkn)
- My University
Challenges in microbial ecology: building predictive understanding of community function and dynamics.
text, January 2016
- Widder, Stefanie; Allen, Rosalind J.; Allen, Rosalind J.
- Apollo - University of Cambridge Repository
Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow
text, January 2017
- Ponomarova, Olga; Gabrielli, Natalia; Sévin, Daniel C.
- ETH Zurich
New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0
text, January 2010
- Guindon, Stéphane; Dufayard, Jean-François; Lefort, Vincent
- Oxford University Press
Bacterial Community Morphogenesis Is Intimately Linked to the Intracellular Redox State
text, January 2013
- Dietrich, Lars; Okegbe, Chinweike; Price-Whelan, Alexa M.
- Columbia University
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
text, January 2010
- Guindon, Stéphane; Dufayard, Jean-François; Lefort, Vincent
- ETH Zurich
Works referencing / citing this record:
Genome and evolution of the arbuscular mycorrhizal fungus Diversispora epigaea (formerly Glomus versiforme ) and its bacterial endosymbionts
journal, October 2018
- Sun, Xuepeng; Chen, Wenbo; Ivanov, Sergey
- New Phytologist, Vol. 221, Issue 3
Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community
journal, June 2019
- Hart, Samuel Frederick Mock; Pineda, Jose Mario Bello; Chen, Chi-Chun
- eLife, Vol. 8