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This content will become publicly available on September 15, 2018

Title: Simultaneous 3D MR elastography of the in vivo mouse brain

The feasibility of sample interval modulation (SLIM) magnetic resonance elastography (MRE) for the in vivo mouse brain is assessed, and an alternative SLIM-MRE encoding method is introduced. In SLIMMRE, the phase accumulation for each motion direction is encoded simultaneously by varying either the start time of the motion encoding gradient (MEG), SLIM-phase constant (SLIM-PC), or the initial phase of the MEG, SLIM-phase varying (SLIM-PV). SLIM-PC provides gradient moment nulling, but the mutual gradient shift necessitates increased echo time (TE). SLIM-PV requires no increased TE, but exhibits nonuniform flow compensation. Comparison was to conventional MRE using six C57BL/6 mice. For SLIMPC, the Spearman’s rank correlation to conventional MRE for the shear storage and loss modulus images were 80% and 76%, respectively, and likewise for SLIM-PV, 73% and 69%, respectively. The results of the Wilcoxon rank sum test showed that there were no statistically significant differences between the spatially averaged shear moduli derived from conventional-MRE, SLIM-PC, and SLIM-PV acquisitions. Both SLIM approaches were comparable to conventional MRE scans with Spearman’s rank correlation of 69%-80% and with 3 times reduction in scan time. As a result, the SLIM-PC method had the best correlation, and SLIM-PV may be a useful tool in experimental conditions,more » where both measurement time and T2 relaxation is critical.« less
Authors:
 [1] ;  [2] ;  [2] ;  [2]
  1. Univ. of Illinois at Chicago, Chicago, IL (United States); Argonne National Lab. (ANL), Argonne, IL (United States)
  2. Univ. of Illinois at Chicago, Chicago, IL (United States)
Publication Date:
Grant/Contract Number:
AC02-06CH11357
Type:
Accepted Manuscript
Journal Name:
Physics in Medicine and Biology (Online)
Additional Journal Information:
Journal Name: Physics in Medicine and Biology (Online); Journal Volume: 62; Journal Issue: 19; Journal ID: ISSN 1361-6560
Publisher:
IOP Publishing
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
Univ. of Illinois at Chicago, Chicago, IL (United States)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; MRE; SLIM; elastography; shear modulus; simultaneous; stiffness
OSTI Identifier:
1434246