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This content will become publicly available on March 6, 2019

Title: Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease

Coregistering quantitative high-resolution metal imaging with fluorescence imaging identifies copper accumulation in megamitochondria within intact neuroretinal slices.
Authors:
ORCiD logo [1] ; ORCiD logo [2] ; ORCiD logo [3] ;  [1] ;  [1] ;  [1] ; ORCiD logo [2] ; ORCiD logo [3]
  1. Department of Chemistry; University of California; Berkeley; USA
  2. Nuclear and Chemical Sciences Division; Lawrence Livermore National Laboratory; Livermore; USA
  3. Department of Chemistry; University of California; Berkeley; USA; Howard Hughes Medical Institute
Publication Date:
Report Number(s):
LLNL-JRNL-745593
Journal ID: ISSN 1756-5901; METAIR
Grant/Contract Number:
AC52-07NA27344; GM 79465; T32 GM066698; SCW1039
Type:
Publisher's Accepted Manuscript
Journal Name:
Metallomics
Additional Journal Information:
Journal Volume: 10; Journal Issue: 3; Related Information: CHORUS Timestamp: 2018-04-20 04:46:59; Journal ID: ISSN 1756-5901
Publisher:
Royal Society of Chemistry
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23). Biological Systems Science Division; National Institutes of Health (NIH); Fannie and John Hertz Foundation; Canadian Inst. for Advanced Research (CIFAR)
Country of Publication:
United Kingdom
Language:
English
OSTI Identifier:
1434089