Evaluating biomarkers to model cancer risk post cosmic ray exposure

Sridharan, Deepa M.; Asaithamby, Aroumougame; Blattnig, Steve R.; Costes, Sylvain V.; Doetsch, Paul W.; Dynan, William S.; Hahnfeldt, Philip; Hlatky, Lynn; Kidane, Yared; Kronenberg, Amy; Naidu, Mamta D.; Peterson, Leif E.; Plante, Ianik; Ponomarev, Artem L.; Saha, Janapriya; Snijders, Antoine M.; Srinivasan, Kalayarasan; Tang, Jonathan; Werner, Erica; Pluth, Janice M.

doi:10.1016/j.lssr.2016.05.004

Title: Evaluating biomarkers to model cancer risk post cosmic ray exposure

Journal Article · 01 June 2016 · Life Sciences in Space Research

DOI: https://doi.org/10.1016/j.lssr.2016.05.004 · OSTI ID:1433733

Sridharan, Deepa M.; Asaithamby, Aroumougame; Blattnig, Steve R.; Costes, Sylvain V.; Doetsch, Paul W.; Dynan, William S.; Hahnfeldt, Philip; Hlatky, Lynn; Kidane, Yared; Kronenberg, Amy; Naidu, Mamta D.; Peterson, Leif E.; Plante, Ianik; Ponomarev, Artem L.; Saha, Janapriya; Snijders, Antoine M.; Srinivasan, Kalayarasan; Tang, Jonathan; Werner, Erica; Pluth, Janice M.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231; SC0002453

OSTI ID:: 1433733

Journal Information:: Life Sciences in Space Research, Journal Name: Life Sciences in Space Research Journal Issue: C Vol. 9; ISSN 2214-5524

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

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Broad Modulation of Gene Expression in CD4 ⁺ Lymphocyte Subpopulations in Response to Low Doses of Ionizing Radiation Gruel, Gaëtan; Voisin, Pascale; Vaurijoux, Aurélie Radiation Research, Vol. 170, Issue 3 https://doi.org/10.1667/RR1147.1	journal	September 2008
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Specific ATM-Mediated Phosphorylation Dependent on Radiation Quality Whalen, Mary K.; Gurai, Sukhleen K.; Zahed-Kargaran, Hengameh Radiation Research, Vol. 170, Issue 3 https://doi.org/10.1667/RR1354.1	journal	September 2008
Induction of Chromosomal Aberrations at Fluences of Less Than One HZE Particle per Cell Nucleus Hada, Megumi; Chappell, Lori J.; Wang, Minli Radiation Research, Vol. 182, Issue 4 https://doi.org/10.1667/RR13721.1	journal	October 2014
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Biological Characterization of Low-Energy Ions with High-Energy Deposition on Human Cells Saha, Janapriya; Wilson, Paul; Thieberger, Peter Radiation Research, Vol. 182, Issue 3 https://doi.org/10.1667/RR13747.1	journal	August 2014
Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation Takahashi, Akihisa; Kubo, Makoto; Ma, Hongyu Radiation Research, Vol. 182, Issue 3 https://doi.org/10.1667/RR13782.1	journal	September 2014
Combinatorial DNA Damage Pairing Model Based on X-Ray-Induced Foci Predicts the Dose and LET Dependence of Cell Death in Human Breast Cells Vadhavkar, Nikhil; Pham, Christopher; Georgescu, Walter Radiation Research, Vol. 182, Issue 3 https://doi.org/10.1667/RR13792.1	journal	September 2014
Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation Sridharan, D. M.; Asaithamby, A.; Bailey, S. M. Radiation Research, Vol. 183, Issue 1 https://doi.org/10.1667/RR13804.1	journal	January 2015
Radiation Quality and Mutagenesis in Human Lymphoblastoid Cells Liber, Howard L.; Idate, Rupa; Warner, Christy Radiation Research, Vol. 182, Issue 4 https://doi.org/10.1667/RR13817.1	journal	September 2014
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Co-culturing with High-Charge and Energy Particle Irradiated Cells Increases Mutagenic Joining of Enzymatically Induced DNA Double-Strand Breaks in Nonirradiated Cells Li, Zhentian; Doho, Gregory; Zheng, Xuan Radiation Research, Vol. 184, Issue 3 https://doi.org/10.1667/RR14092.1	journal	September 2015
Accelerated ⁴⁸ Ti Ions Induce Autosomal Mutations in Mouse Kidney Epithelium at Low Dose and Fluence Hryciw, Gwen; Grygoryev, Dmytro; Lasarev, Michael Radiation Research, Vol. 184, Issue 4 https://doi.org/10.1667/RR14130.1	journal	October 2015
DNA Fragmentation Induced in Human Fibroblasts by ⁵⁶ Fe Ions: Experimental Data and Monte Carlo Simulations Campa, A.; Alloni, D.; Antonelli, F. Radiation Research, Vol. 171, Issue 4 https://doi.org/10.1667/RR1442.1	journal	April 2009
Contributions of Direct and Indirect Actions in Cell Killing by High-LET Radiations Hirayama, Ryoichi; Ito, Atsushi; Tomita, Masanori Radiation Research, Vol. 171, Issue 2 https://doi.org/10.1667/RR1490.1	journal	February 2009
Positional Stability of Damaged Chromatin Domains along Radiation Tracks in Mammalian Cells Jakob, B.; Splinter, J.; Taucher-Scholz, G. Radiation Research, Vol. 171, Issue 4, p. 405-418 https://doi.org/10.1667/RR1520.1	journal	April 2009
Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon ⁵⁶ Fe Ions, X Rays or γ Rays. Part I. Experimental Observations Peng, Yuanlin; Brown, Natalie; Finnon, Rosemary Radiation Research, Vol. 171, Issue 4 https://doi.org/10.1667/RR1547.1	journal	April 2009
Gene Expression Profile of Human Lymphocytes Exposed to ²¹¹ At α Particles Turtoi, A.; Brown, I.; Schläger, M. Radiation Research, Vol. 174, Issue 2 https://doi.org/10.1667/RR1659.1	journal	August 2010
Comparative Analysis of Cell Killing and Autosomal Mutation in Mouse Kidney Epithelium Exposed to 1 GeV/nucleon Iron Ions In Vitro or In Situ Kronenberg, Amy; Gauny, Stacey; Kwoh, Ely Radiation Research, Vol. 172, Issue 5 https://doi.org/10.1667/RR1804.1	journal	November 2009
Comparison of Autosomal Mutations in Mouse Kidney Epithelial Cells Exposed to Iron Ions In Situ or in Culture Turker, Mitchell S.; Connolly, Lanelle; Dan, Cristian Radiation Research, Vol. 172, Issue 5 https://doi.org/10.1667/RR1805.1	journal	November 2009
Animal Models for Medical Countermeasures to Radiation Exposure Williams, Jacqueline P.; Brown, Stephen L.; Georges, George E. Radiation Research, Vol. 173, Issue 4 https://doi.org/10.1667/RR1880.1	journal	April 2010
Transient Activation of the ALT Pathway in Human Primary Fibroblasts Exposed to High-LET Radiation Berardinelli, F.; Antoccia, A.; Cherubini, R. Radiation Research, Vol. 174, Issue 5 https://doi.org/10.1667/RR2127.1	journal	November 2010
Effects of Low-Dose Radiation on the Immune System of Mice after Total-Body Irradiation Bogdándi, Enikő Noémi; Balogh, Andrea; Felgyinszki, Nikolett Radiation Research, Vol. 174, Issue 4 https://doi.org/10.1667/RR2160.1	journal	October 2010
Long-Term Consequences of Radiation-Induced Bystander Effects Depend on Radiation Quality and Dose and Correlate with Oxidative Stress Buonanno, Manuela; de Toledo, Sonia M.; Pain, Debkumar Radiation Research, Vol. 175, Issue 4 https://doi.org/10.1667/RR2461.1	journal	April 2011
Global Gene Expression Responses to Low- or High-Dose Radiation in a Human Three-Dimensional Tissue Model Mezentsev, Alexandre; Amundson, Sally A. Radiation Research, Vol. 175, Issue 6 https://doi.org/10.1667/RR2483.1	journal	April 2011
Transcriptional Response of Ex Vivo Human Skin to Ionizing Radiation: Comparison Between Low- and High-Dose Effects Albrecht, Huguette; Durbin-Johnson, Blythe; Yunis, Reem Radiation Research, Vol. 177, Issue 1 https://doi.org/10.1667/RR2524.1	journal	January 2012
p53-Independent Downregulation of Histone Gene Expression in Human Cell Lines by High- and Low-LET Radiation Meador, Jarah A.; Ghandhi, Shanaz A.; Amundson, Sally A. Radiation Research, Vol. 175, Issue 6 https://doi.org/10.1667/RR2539.1	journal	April 2011
Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures? Blyth, Benjamin J.; Sykes, Pamela J. Radiation Research, Vol. 176, Issue 2 https://doi.org/10.1667/RR2548.1	journal	August 2011
Effects of Very Low Fluences of High-Energy Protons or Iron Ions on Irradiated and Bystander Cells Yang, H.; Magpayo, N.; Rusek, A. Radiation Research, Vol. 176, Issue 6 https://doi.org/10.1667/RR2674.1	journal	December 2011
Proton Irradiation Suppresses Angiogenic Genes and Impairs Cell Invasion and Tumor Growth Girdhani, Swati; Lamont, Clare; Hahnfeldt, Philip Radiation Research, Vol. 178, Issue 1 https://doi.org/10.1667/RR2724.1	journal	June 2012
Gene Expression Comparisons Performed for Biodosimetry Purposes on In Vitro Peripheral Blood Cellular Subsets and Irradiated Individuals Riecke, A.; Rufa, C. G.; Cordes, M. Radiation Research, Vol. 178, Issue 3 https://doi.org/10.1667/RR2738.1	journal	September 2012
Biological Effects of Proton Radiation: What We Know and Don't Know Girdhani, Swati; Sachs, Rainer; Hlatky, Lynn Radiation Research, Vol. 179, Issue 3 https://doi.org/10.1667/RR2839.1	journal	March 2013
The Effect of Dose Rate on the Frequency of Specific-Locus Mutations Induced in Mouse Spermatogonia is Restricted to Larger Lesions; a Retrospective Analysis of Historical Data Russell, Liane B.; Hunsicker, Patricia R. Radiation Research, Vol. 177, Issue 5 https://doi.org/10.1667/RR2853.1	journal	March 2012
Gene Expression in Low- and High-Dose-Irradiated Human Peripheral Blood Lymphocytes: Possible Applications for Biodosimetry Knops, Katja; Boldt, Sonja; Wolkenhauer, Olaf Radiation Research, Vol. 178, Issue 4 https://doi.org/10.1667/RR2913.1	journal	September 2012
Nontargeted Stressful Effects in Normal Human Fibroblast Cultures Exposed to Low Fluences of High Charge, High Energy (HZE) Particles: Kinetics of Biologic Responses and Significance of Secondary Radiations Gonon, Géraldine; Groetz, Jean-Emmanuel; de Toledo, Sonia M. Radiation Research, Vol. 179, Issue 4 https://doi.org/10.1667/RR3017.1	journal	March 2013
Comparative Analysis of Cell Killing and Autosomal Mutation in Mouse Kidney Epithelium Exposed to 1 GeV Protons In Vitro or In Vivo Kronenberg, Amy; Gauny, Stacey; Kwoh, Ely Radiation Research, Vol. 179, Issue 5 https://doi.org/10.1667/RR3182.1	journal	May 2013
Spaceflight Environment Induces Mitochondrial Oxidative Damage in Ocular Tissue Mao, Xiao W.; Pecaut, Michael J.; Stodieck, Louis S. Radiation Research, Vol. 180, Issue 4 https://doi.org/10.1667/RR3309.1	journal	October 2013
Proton-Induced Genetic Damage in lacZ Transgenic Mice Chang, Polly Y.; Bakke, James; Orduna, Juan Radiation Research, Vol. 164, Issue 4 https://doi.org/10.1667/RR3322.1	journal	October 2005
Gene Expression Changes in Normal Human Skin Fibroblasts Induced by HZE-Particle Radiation Ding, Liang-Hao; Shingyoji, Masato; Chen, Fanqing Radiation Research, Vol. 164, Issue 4 https://doi.org/10.1667/RR3350.1	journal	October 2005
Biomarkers of Space Radiation Risk Durante, Marco Radiation Research, Vol. 164, Issue 4 https://doi.org/10.1667/RR3359.1	journal	October 2005
LET and Ion Species Dependence for Cell Killing in Normal Human Skin Fibroblasts Tsuruoka, Chizuru; Suzuki, Masao; Kanai, Tatsuaki Radiation Research, Vol. 163, Issue 5 https://doi.org/10.1667/RR3360	journal	May 2005
Efficient Production of Reactive Oxygen Species in Neural Precursor Cells after Exposure to 250 MeV Protons Giedzinski, Erich; Rola, Radoslaw; Fike, John R. Radiation Research, Vol. 164, Issue 4 https://doi.org/10.1667/RR3369.1	journal	October 2005
Computational Methods for Analysis of Foci: Validation for Radiation-Induced γ-H2AX Foci in Human Cells Böcker, Wilfried; Iliakis, George Radiation Research, Vol. 165, Issue 1, p. 113-124 https://doi.org/10.1667/RR3486.1	journal	January 2006
Repair of DNA Damage Induced by Accelerated Heavy Ions in Mammalian Cells Proficient and Deficient in the Non-homologous End-Joining Pathway Okayasu, Ryuichi; Okada, Maki; Okabe, Atsushi Radiation Research, Vol. 165, Issue 1 https://doi.org/10.1667/RR3489.1	journal	January 2006
Spectrum of Complex DNA Damages Depends on the Incident Radiation Hada, Megumi; Sutherland, Betsy M. Radiation Research, Vol. 165, Issue 2 https://doi.org/10.1667/RR3498.1	journal	February 2006
Effective Cross Sections for Production of Single-Strand Breaks in Plasmid DNA by 0.1 to 4.7 eV Electrons Panajotovic, Radmila; Martin, Frédéric; Cloutier, Pierre Radiation Research, Vol. 165, Issue 4 https://doi.org/10.1667/RR3521.1	journal	April 2006
Imaging Features that Discriminate between Foci Induced by High- and Low-LET Radiation in Human Fibroblasts Costes, Sylvain V.; Boissière, Arnaud; Ravani, Shraddha Radiation Research, Vol. 165, Issue 5, p. 505-515 https://doi.org/10.1667/RR3538.1	journal	May 2006
Levels of γ-H2AX Foci after Low-Dose-Rate Irradiation Reveal a DNA DSB Rejoining Defect in Cells from Human ATM Heterozygotes in Two AT Families and in Another Apparently Normal Individual Kato, Takamitsu A.; Nagasawa, Hatsumi; Weil, Michael M. Radiation Research, Vol. 166, Issue 3 https://doi.org/10.1667/RR3604.1	journal	September 2006
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Gene set enrichment analysis highlights different gene expression profiles in whole blood samples X-irradiated with low and high doses El-Saghire, Houssein; Thierens, Hubert; Monsieurs, Pieter International Journal of Radiation Biology, Vol. 89, Issue 8 https://doi.org/10.3109/09553002.2013.782448	journal	April 2013
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Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells Berardinelli, Francesco; Sgura, Antonellla; Di Masi, Alessandra International Journal of Radiation Biology, Vol. 90, Issue 1 https://doi.org/10.3109/09553002.2014.859400	journal	September 2013
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Stress-induced DNA damage biomarkers: applications and limitations Nikitaki, Zacharenia; Hellweg, Christine E.; Georgakilas, Alexandros G. Frontiers in Chemistry, Vol. 3 https://doi.org/10.3389/fchem.2015.00035	journal	June 2015
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Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model Moroni, Maria; Maeda, Daisuke; Whitnall, Mark International Journal of Molecular Sciences, Vol. 14, Issue 7 https://doi.org/10.3390/ijms140714119	journal	July 2013
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X-ray-Induced Changes in the Expression of Inflammation-Related Genes in Human Peripheral Blood Wang, Ping; Guo, Fei; Han, Lin International Journal of Molecular Sciences, Vol. 15, Issue 11 https://doi.org/10.3390/ijms151119516	journal	October 2014
γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization Löbrich, Markus; Shibata, Atsushi; Beucher, Andrea Cell Cycle, Vol. 9, Issue 4 https://doi.org/10.4161/cc.9.4.10764	journal	February 2010
γH2AX as a molecular marker of aging and disease Mah, Li-Jeen; El-Osta, Assam; Karagiannis, Tom C. Epigenetics, Vol. 5, Issue 2 https://doi.org/10.4161/epi.5.2.11080	journal	February 2010
Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming Li, Heng-Hong; Wang, Yi-wen; Chen, Renxiang International Journal of Biological Sciences, Vol. 11, Issue 7 https://doi.org/10.7150/ijbs.12009	journal	January 2015

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