Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model

Rogers, Tara S.; Garrod, Marjorie G.; Peerson, Janet M.; Hillegonds, Darren J.; Buchholz, Bruce A.; Demmer, Elieke; Richardson, Christine; Gertz, Erik R.; Van Loan, Marta D.

doi:10.1016/j.bonr.2016.05.001

Title: Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model

Full Record
Other Related Research

Abstract

Few interventions directly compare equivalent calcium and vitamin D from dairy vs. supplements on the same bone outcomes. Here, the radioisotope calcium-41 (⁴¹Ca) holds promise as a tracer method to directly measure changes in bone resorption with differing dietary interventions.

Authors:: Rogers, Tara S.; Garrod, Marjorie G.; Peerson, Janet M.; Hillegonds, Darren J.; Buchholz, Bruce A.; Demmer, Elieke; Richardson, Christine; Gertz, Erik R.; Van Loan, Marta D.

Publication Date:: 2016-12-01

Research Org.:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1433732

Alternate Identifier(s):: OSTI ID: 1259784

Report Number(s):: LLNL-JRNL-681317
Journal ID: ISSN 2352-1872; S235218721630016X; PII: S235218721630016X

Grant/Contract Number:: AC52-07NA27344; 681317

Resource Type:: Published Article

Journal Name:: Bone Reports

Additional Journal Information:: Journal Name: Bone Reports Journal Volume: 5 Journal Issue: C; Journal ID: ISSN 2352-1872

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 41Ca; dairy; calcium supplement; kinetic model; postmenopausal

Citation Formats


                    Rogers, Tara S., Garrod, Marjorie G., Peerson, Janet M., Hillegonds, Darren J., Buchholz, Bruce A., Demmer, Elieke, Richardson, Christine, Gertz, Erik R., and Van Loan, Marta D. Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model.  United States: N. p., 2016. 
Web.  doi:10.1016/j.bonr.2016.05.001.

Copy to clipboard


                    Rogers, Tara S., Garrod, Marjorie G., Peerson, Janet M., Hillegonds, Darren J., Buchholz, Bruce A., Demmer, Elieke, Richardson, Christine, Gertz, Erik R., & Van Loan, Marta D. Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model.  United States.  https://doi.org/10.1016/j.bonr.2016.05.001

Copy to clipboard


                    Rogers, Tara S., Garrod, Marjorie G., Peerson, Janet M., Hillegonds, Darren J., Buchholz, Bruce A., Demmer, Elieke, Richardson, Christine, Gertz, Erik R., and Van Loan, Marta D. Thu .  
"Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model".  United States.  https://doi.org/10.1016/j.bonr.2016.05.001.

Copy to clipboard


                    
@article{osti_1433732,

  title        = {Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model},

  author       = {Rogers, Tara S. and Garrod, Marjorie G. and Peerson, Janet M. and Hillegonds, Darren J. and Buchholz, Bruce A. and Demmer, Elieke and Richardson, Christine and Gertz, Erik R. and Van Loan, Marta D.},

  abstractNote = {Few interventions directly compare equivalent calcium and vitamin D from dairy vs. supplements on the same bone outcomes. Here, the radioisotope calcium-41 (41Ca) holds promise as a tracer method to directly measure changes in bone resorption with differing dietary interventions.},

  doi          = {10.1016/j.bonr.2016.05.001},

  journal      = {Bone Reports},

  number       = C,

  volume       = 5,

  place        = {United States},

  year         = {2016},

  month        = {12}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
https://doi.org/10.1016/j.bonr.2016.05.001

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Effect of dietary calcium on bone metabolism in young and aged female rats using a short-term in vivo model

Journal Article Sinha, R ; Smith, Jr, J C ; Soares, Jr, J H - J. Nutr.; (United States)

The use of high dietary calcium supplementation in the treatment of patients with osteoporosis is controversial. The present study examined the mechanisms underlying the effects of calcium supplementation by investigating the influence of dietary calcium on bone dynamics in young and aged rats. A 2 x 2 x 2 factorial design was utilized with 0.2% (low) or 1.0% (high) calcium, 2- or 24-m-old female Long-Evans rats that were implanted subcutaneously with demineralized (DB) and mineralized (MB) bone powder. The four groups of rats were fed each of the respective diets for 11 wk and then implanted with one number5 gelatinmore »« less
Radionuclide Mineral Studies,: 3. The Effect of Breed and Dietary Zinc, Calcium, and Vitamin D3 on the Retention of Zinc65 in Chicks

Journal Article Martin, W. G. ; Patrick, H. - Poultry Science

Chicks were fed soybean protein- cerelose basal ration containing a tricalcium phosphate- calcium carbonate mineral mixture. Growth and general appearance were improved by the supplementation of Zn up to 30 ppm, and bone abnormalities and skin lesions were abolished by supplementation of 40 to 60 ppm of Zn. Breed differences were observed. The overall retention of Zn⁶⁵ in the tibia was higher in the New Hampshire and New Hampshire x White Leghorn chicks than in White Leghorn and White Leghorn x New Hampshire chicks at 21 days of age. Liver Zn⁶⁵ uptake was decreased steadily by increasing dietary Zn supplementation,more »« less
https://doi.org/10.3382/ps.0401004
Human calcium metabolism including bone resorption measured with {sup 41}Ca tracer

Conference Freeman, S P.H.T. ; King, J C ; Vieira, N E ; ...

Accelerator mass spectrometry is so sensitive to small quantities of {sup 41}Ca that it might be used as a tracer in the study of human calcium kinetics to generate unique kinds of data. In contrast with the use of other Ca isotopic tracers, {sup 41}Ca tracer can be so administered that the tracer movements between the various body pools achieve a quasi steady state. Resorbing bone may thus be directly measured. We have tested such a protocol against a conventional stable isotope experiment with good agreement.
Full Text Available
Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein

Journal Article Fullmer, C S ; Oku, T ; Wasserman, R H - Environ. Res.; (United States)

The effects of cadmium on intestinal calcium absorption and calcium-binding protein (CaBP) were investigated in chicks by means of the in situ ligated duodenal loop technique. Dietary cadmium, administered in the feed or by gastric intubation, resulted in significant declines in intestinal calcium absorption and mucosal calcium-binding protein concentrations. Cadmium chloride injected directly into the ligated loop of naive chicks also diminished calcium absorption and CaBP concentrations in an apparently dose-response related fashion. No adverse effects of cadmium administration on either the 25- or 1..cap alpha..-hydroxylation reactions of vitamin D were observed. While the general effect of cadmium administration wasmore »« less
https://doi.org/10.1016/0013-9351(80)90150-4
Theophylline, a methylxanthine drug induces osteopenia and alters calciotropic hormones, and prophylactic vitamin D treatment protects against these changes in rats

Journal Article Pal, Subhashis ; Khan, Kainat ; China, Shyamsundar Pal ; ... - Toxicology and Applied Pharmacology

The drug, theophylline is frequently used as an additive to medications for people suffering from chronic obstructive pulmonary diseases (COPD). We studied the effect of theophylline in bone cells, skeleton and parameters related to systemic calcium homeostasis. Theophylline induced osteoblast apoptosis by increasing reactive oxygen species production that was caused by increased cAMP production. Bone marrow levels of theophylline were higher than its serum levels, indicating skeletal accumulation of this drug. When adult Sprague-Dawley rats were treated with theophylline, bone regeneration at fracture site was diminished compared with control. Theophylline treatment resulted in a time-dependent (at 4- and 8 weeks)more »« less
https://doi.org/10.1016/J.TAAP.2016.02.002

Similar Records