Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches
Abstract
Follicular helper (TFH) and regulatory (TFR) cells are essential players in managing germinal center (GC) reactions that accomplish effective humoral immune responses. Transcriptome analyses were done comparing gene regulation of TFH and TFR cells isolated from Peyer’s Patches (PP) and immunized peripheral lymph nodes (pLNs) revealing many regulatory patterns common to all follicular cells. Yet, in contrast to TFH cells, the upregulation or downregulation of many genes was attenuated substantially in pLN TFR cells when compared to those of PP. Additionally, PP but not pLN TFR cells were largely unresponsive to IL2 and expressed Il4 as well as Il21. Together with fundamental differences in gene expression that were found between cells of both compartments this emphasizes specific adaptations of follicular T cell functions to their micro-milieu. Furthermore, although GL7 expression distinguishes matured follicular T cells, GL7+ as well as GL7– cells are present in the GC.
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1432391
- Alternate Identifier(s):
- OSTI ID: 1527289
- Report Number(s):
- LLNL-JRNL-741132
Journal ID: ISSN 1664-3224; 714
- Grant/Contract Number:
- AC52-07NA27344
- Resource Type:
- Published Article
- Journal Name:
- Frontiers in Immunology
- Additional Journal Information:
- Journal Name: Frontiers in Immunology Journal Volume: 9; Journal ID: ISSN 1664-3224
- Publisher:
- Frontiers Media SA
- Country of Publication:
- Switzerland
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, and Bernhardt, Günter. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches. Switzerland: N. p., 2018.
Web. doi:10.3389/fimmu.2018.00714.
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, & Bernhardt, Günter. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches. Switzerland. https://doi.org/10.3389/fimmu.2018.00714
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, and Bernhardt, Günter. Mon .
"Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches". Switzerland. https://doi.org/10.3389/fimmu.2018.00714.
@article{osti_1432391,
title = {Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches},
author = {Georgiev, Hristo and Ravens, Inga and Papadogianni, Georgia and Halle, Stephan and Malissen, Bernard and Loots, Gabriela G. and Förster, Reinhold and Bernhardt, Günter},
abstractNote = {Follicular helper (TFH) and regulatory (TFR) cells are essential players in managing germinal center (GC) reactions that accomplish effective humoral immune responses. Transcriptome analyses were done comparing gene regulation of TFH and TFR cells isolated from Peyer’s Patches (PP) and immunized peripheral lymph nodes (pLNs) revealing many regulatory patterns common to all follicular cells. Yet, in contrast to TFH cells, the upregulation or downregulation of many genes was attenuated substantially in pLN TFR cells when compared to those of PP. Additionally, PP but not pLN TFR cells were largely unresponsive to IL2 and expressed Il4 as well as Il21. Together with fundamental differences in gene expression that were found between cells of both compartments this emphasizes specific adaptations of follicular T cell functions to their micro-milieu. Furthermore, although GL7 expression distinguishes matured follicular T cells, GL7+ as well as GL7– cells are present in the GC.},
doi = {10.3389/fimmu.2018.00714},
journal = {Frontiers in Immunology},
number = ,
volume = 9,
place = {Switzerland},
year = {Mon Apr 09 00:00:00 EDT 2018},
month = {Mon Apr 09 00:00:00 EDT 2018}
}
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https://doi.org/10.3389/fimmu.2018.00714
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