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Title: Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

Journal Article · · Frontiers in Immunology

Not Available

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC52-07NA27344
OSTI ID:
1432391
Report Number(s):
LLNL-JRNL--741132; 714
Journal Information:
Frontiers in Immunology, Journal Name: Frontiers in Immunology Vol. 9; ISSN 1664-3224
Publisher:
Frontiers Media SACopyright Statement
Country of Publication:
Switzerland
Language:
English

References (70)

Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression journal July 2006
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human Bcells: Differential effects of BMP-6 and BMP-7 journal October 2011
The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives journal October 2012
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis journal June 2013
A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells journal July 2008
Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling journal April 2009
The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment journal September 2009
Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone journal June 2011
How T Cells Earn the Follicular Rite of Passage journal November 2011
Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V journal February 2012
The 3′ Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells journal February 2012
Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation journal May 2012
Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis journal July 2014
T Follicular Helper Cell Differentiation, Function, and Roles in Disease journal October 2014
The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation journal February 2015
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells journal October 2015
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells journal January 2016
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells journal January 2017
GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation journal July 2015
Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system journal June 2008
Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot journal December 2003
Foxp3-dependent programme of regulatory T-cell differentiation journal January 2007
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development journal January 2014
Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop journal September 2016
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 journal March 2017
T follicular helper and T follicular regulatory cells have different TCR specificity journal April 2017
Batf is important for IL-4 expression in T follicular helper cells journal August 2015
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells journal December 2008
Cytokine-secreting follicular T cells shape the antibody repertoire journal March 2009
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells journal May 2011
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse journal April 2012
Metabolic checkpoints in activated T cells journal September 2012
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood journal December 2012
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses journal March 2013
Bcl-6 directly represses the gene program of the glycolysis pathway journal September 2014
TFH cells progressively differentiate to regulate the germinal center response journal August 2016
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function journal October 2016
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection journal September 2017
Gadd45β is important for perpetuating cognate and inflammatory signals in T cells journal December 2003
Lymphoid reservoirs of antigen-specific memory T helper cells journal May 2007
Foxp3+ follicular regulatory T cells control the germinal center response journal July 2011
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions journal July 2011
Molecular and cellular insights into T cell exhaustion journal July 2015
GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells journal July 2009
Dynamic control of  1 integrin adhesion by the plexinD1-sema3E axis journal December 2013
A distinct subpopulation of CD25 T-follicular regulatory cells localizes in the germinal centers journal July 2017
CCAAT/Enhancer-binding Protein α (C/EBPα) Is Critical for Interleukin-4 Expression in Response to FcϵRI Receptor Cross-linking journal March 2011
Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells journal July 2011
Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis journal May 1997
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production journal November 2000
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells journal November 2010
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 journal May 2012
T-cell subsets in the germinal center journal February 2013
Peyer's patches: organizing B-cell responses at the intestinal frontier journal April 2016
T follicular regulatory cells journal April 2016
PSGL-1 function in immunity and steady state homeostasis journal July 2009
Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches journal March 2009
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation journal July 2009
T Follicular Helper Cell Dynamics in Germinal Centers journal July 2013
IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches journal May 2016
Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function journal April 2017
Circulating T follicular regulatory and helper cells have memory-like properties journal October 2014
Hemophagocytic lymphohistiocytosis in syntaxin-11–deficient mice: T-cell exhaustion limits fatal disease journal January 2013
The impact of cell-bound antigen transport on mucosal tolerance induction journal June 2007
Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150) journal June 2010
IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells journal July 2013
Regulated Compartmentalization of Programmed Cell Death-1 Discriminates CD4 + CD25 + Resting Regulatory T Cells from Activated T Cells journal February 2006
ICOS Deficiency Is Associated with a Severe Reduction of CXCR5 + CD4 Germinal Center Th Cells journal September 2006
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1 High Germinal Center-Associated Subpopulation journal October 2007
Th2 Lymphoproliferative Disorder of Lat Y136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3 + Regulatory T Cells journal January 2008

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