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Title: Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1432391
Alternate Identifier(s):
OSTI ID: 1527289
Report Number(s):
LLNL-JRNL-741132
Journal ID: ISSN 1664-3224; 714
Grant/Contract Number:  
AC52-07NA27344
Resource Type:
Published Article
Journal Name:
Frontiers in Immunology
Additional Journal Information:
Journal Name: Frontiers in Immunology Journal Volume: 9; Journal ID: ISSN 1664-3224
Publisher:
Frontiers Media SA
Country of Publication:
Switzerland
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, and Bernhardt, Günter. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches. Switzerland: N. p., 2018. Web. doi:10.3389/fimmu.2018.00714.
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, & Bernhardt, Günter. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches. Switzerland. doi:10.3389/fimmu.2018.00714.
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold, and Bernhardt, Günter. Mon . "Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches". Switzerland. doi:10.3389/fimmu.2018.00714.
@article{osti_1432391,
title = {Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches},
author = {Georgiev, Hristo and Ravens, Inga and Papadogianni, Georgia and Halle, Stephan and Malissen, Bernard and Loots, Gabriela G. and Förster, Reinhold and Bernhardt, Günter},
abstractNote = {},
doi = {10.3389/fimmu.2018.00714},
journal = {Frontiers in Immunology},
number = ,
volume = 9,
place = {Switzerland},
year = {2018},
month = {4}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.3389/fimmu.2018.00714

Citation Metrics:
Cited by: 3 works
Citation information provided by
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Works referenced in this record:

A distinct subpopulation of CD25 T-follicular regulatory cells localizes in the germinal centers
journal, July 2017

  • Wing, James Badger; Kitagawa, Yohko; Locci, Michela
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 31
  • DOI: 10.1073/pnas.1705551114

CCAAT/Enhancer-binding Protein α (C/EBPα) Is Critical for Interleukin-4 Expression in Response to FcϵRI Receptor Cross-linking
journal, March 2011

  • Qi, Xiaopeng; Nishida, Jun; Chaves, Lee
  • Journal of Biological Chemistry, Vol. 286, Issue 18
  • DOI: 10.1074/jbc.M110.213389

How T Cells Earn the Follicular Rite of Passage
journal, November 2011


Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
journal, October 2016

  • Sage, Peter T.; Ron-Harel, Noga; Juneja, Vikram R.
  • Nature Immunology, Vol. 17, Issue 12
  • DOI: 10.1038/ni.3578

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
journal, January 2014


Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
journal, September 2016

  • Kuwahara, Makoto; Ise, Wataru; Ochi, Mizuki
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12596

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells
journal, July 2008


T follicular helper and T follicular regulatory cells have different TCR specificity
journal, April 2017

  • Maceiras, Ana Raquel; Almeida, Silvia Cristina Paiva; Mariotti-Ferrandiz, Encarnita
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms15067

SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells
journal, January 2017


T Follicular Helper Cell Differentiation, Function, and Roles in Disease
journal, October 2014


Th2 Lymphoproliferative Disorder of Lat Y136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3 + Regulatory T Cells
journal, January 2008


Gadd45β is important for perpetuating cognate and inflammatory signals in T cells
journal, December 2003

  • Lu, Binfeng; Ferrandino, Anthony F.; Flavell, Richard A.
  • Nature Immunology, Vol. 5, Issue 1
  • DOI: 10.1038/ni1020

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
journal, July 2011

  • Chung, Yeonseok; Tanaka, Shinya; Chu, Fuliang
  • Nature Medicine, Vol. 17, Issue 8
  • DOI: 10.1038/nm.2426

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5 + CD4 Germinal Center Th Cells
journal, September 2006


GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation
journal, July 2015


T-cell subsets in the germinal center
journal, February 2013

  • Ramiscal, Roybel R.; Vinuesa, Carola G.
  • Immunological Reviews, Vol. 252, Issue 1
  • DOI: 10.1111/imr.12031

Foxp3+ follicular regulatory T cells control the germinal center response
journal, July 2011

  • Linterman, Michelle A.; Pierson, Wim; Lee, Sau K.
  • Nature Medicine, Vol. 17, Issue 8
  • DOI: 10.1038/nm.2425

Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells
journal, July 2011

  • Lamsoul, Isabelle; Burande, Clara F.; Razinia, Ziba
  • Journal of Biological Chemistry, Vol. 286, Issue 35
  • DOI: 10.1074/jbc.M111.220921

Cytokine-secreting follicular T cells shape the antibody repertoire
journal, March 2009

  • Reinhardt, R. Lee; Liang, Hong-Erh; Locksley, Richard M.
  • Nature Immunology, Vol. 10, Issue 4
  • DOI: 10.1038/ni.1715

Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system
journal, June 2008


T Follicular Helper Cell Dynamics in Germinal Centers
journal, July 2013


The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
journal, December 2012

  • Sage, Peter T.; Francisco, Loise M.; Carman, Christopher V.
  • Nature Immunology, Vol. 14, Issue 2
  • DOI: 10.1038/ni.2496

Dynamic control of  1 integrin adhesion by the plexinD1-sema3E axis
journal, December 2013

  • Choi, Y. I.; Duke-Cohan, J. S.; Chen, W.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 1
  • DOI: 10.1073/pnas.1314209111

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
journal, October 2015


Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V
journal, February 2012


Circulating T follicular regulatory and helper cells have memory-like properties
journal, October 2014

  • Sage, Peter T.; Alvarez, David; Godec, Jernej
  • Journal of Clinical Investigation, Vol. 124, Issue 12
  • DOI: 10.1172/JCI76861

The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation
journal, February 2015


IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
journal, March 2017

  • Jandl, Christoph; Liu, Sue M.; Cañete, Pablo F.
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms14647

Hemophagocytic lymphohistiocytosis in syntaxin-11–deficient mice: T-cell exhaustion limits fatal disease
journal, January 2013


Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)
journal, June 2010

  • Yusuf, Isharat; Kageyama, Robin; Monticelli, Laurel
  • The Journal of Immunology, Vol. 185, Issue 1
  • DOI: 10.4049/jimmunol.0903505

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells
journal, July 2009

  • Tran, D. Q.; Andersson, J.; Wang, R.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 32
  • DOI: 10.1073/pnas.0901944106

Lymphoid reservoirs of antigen-specific memory T helper cells
journal, May 2007

  • Fazilleau, Nicolas; Eisenbraun, Michael D.; Malherbe, Laurent
  • Nature Immunology, Vol. 8, Issue 7
  • DOI: 10.1038/ni1472

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
journal, September 2009


IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
journal, November 2010

  • Batten, Marcel; Ramamoorthi, Nandhini; Kljavin, Noelyn M.
  • The Journal of Experimental Medicine, Vol. 207, Issue 13
  • DOI: 10.1084/jem.20100064

The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives
journal, October 2012

  • Kannan, Meenakshi B.; Solovieva, Vera; Blank, Volker
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1823, Issue 10
  • DOI: 10.1016/j.bbamcr.2012.06.012

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
journal, June 2011


TFH cells progressively differentiate to regulate the germinal center response
journal, August 2016

  • Weinstein, Jason S.; Herman, Edward I.; Lainez, Begoña
  • Nature Immunology, Vol. 17, Issue 10
  • DOI: 10.1038/ni.3554

Metabolic checkpoints in activated T cells
journal, September 2012

  • Wang, Ruoning; Green, Douglas R.
  • Nature Immunology, Vol. 13, Issue 10
  • DOI: 10.1038/ni.2386

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
journal, April 2009


Bcl-6 directly represses the gene program of the glycolysis pathway
journal, September 2014

  • Oestreich, Kenneth J.; Read, Kaitlin A.; Gilbertson, Sarah E.
  • Nature Immunology, Vol. 15, Issue 10
  • DOI: 10.1038/ni.2985

Batf is important for IL-4 expression in T follicular helper cells
journal, August 2015

  • Sahoo, Anupama; Alekseev, Andrei; Tanaka, Kentaro
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8997

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis
journal, May 1997

  • Zhang, Xiaohong; Brunner, Thomas; Carter, Laura
  • The Journal of Experimental Medicine, Vol. 185, Issue 10
  • DOI: 10.1084/jem.185.10.1837

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
journal, June 2013


The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
journal, December 2008

  • Bauquet, Aurelie T.; Jin, Hulin; Paterson, Alison M.
  • Nature Immunology, Vol. 10, Issue 2
  • DOI: 10.1038/ni.1690

Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression
journal, July 2006

  • Rasheed, Ata-Ur; Rahn, Hans-Peter; Sallusto, Federica
  • European Journal of Immunology, Vol. 36, Issue 7
  • DOI: 10.1002/eji.200636136

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
journal, April 2012

  • Lüthje, Katja; Kallies, Axel; Shimohakamada, Yoko
  • Nature Immunology, Vol. 13, Issue 5
  • DOI: 10.1038/ni.2261

T follicular regulatory cells
journal, April 2016

  • Sage, Peter T.; Sharpe, Arlene H.
  • Immunological Reviews, Vol. 271, Issue 1
  • DOI: 10.1111/imr.12411

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
journal, July 2009


Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1 High Germinal Center-Associated Subpopulation
journal, October 2007

  • Haynes, Nicole M.; Allen, Christopher D. C.; Lesley, Robin
  • The Journal of Immunology, Vol. 179, Issue 8
  • DOI: 10.4049/jimmunol.179.8.5099

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation
journal, May 2012


Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection
journal, September 2017

  • Botta, Davide; Fuller, Michael J.; Marquez-Lago, Tatiana T.
  • Nature Immunology, Vol. 18, Issue 11
  • DOI: 10.1038/ni.3837

Molecular and cellular insights into T cell exhaustion
journal, July 2015

  • Wherry, E. John; Kurachi, Makoto
  • Nature Reviews Immunology, Vol. 15, Issue 8
  • DOI: 10.1038/nri3862

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
journal, November 2000

  • Breitfeld, Dagmar; Ohl, Lars; Kremmer, Elisabeth
  • The Journal of Experimental Medicine, Vol. 192, Issue 11
  • DOI: 10.1084/jem.192.11.1545

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
journal, December 2003


Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses
journal, March 2013

  • Hirota, Keiji; Turner, Jan-Eric; Villa, Matteo
  • Nature Immunology, Vol. 14, Issue 4
  • DOI: 10.1038/ni.2552

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function
journal, April 2017


Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human Bcells: Differential effects of BMP-6 and BMP-7
journal, October 2011

  • Huse, Kanutte; Bakkebø, Maren; Oksvold, Morten P.
  • European Journal of Immunology, Vol. 41, Issue 11
  • DOI: 10.1002/eji.201141558

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
journal, May 2011

  • Ise, Wataru; Kohyama, Masako; Schraml, Barbara U.
  • Nature Immunology, Vol. 12, Issue 6
  • DOI: 10.1038/ni.2037

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
journal, May 2012

  • Yokosuka, Tadashi; Takamatsu, Masako; Kobayashi-Imanishi, Wakana
  • The Journal of Experimental Medicine, Vol. 209, Issue 6
  • DOI: 10.1084/jem.20112741

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
journal, January 2016


Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches
journal, March 2009


PSGL-1 function in immunity and steady state homeostasis
journal, July 2009


Peyer's patches: organizing B-cell responses at the intestinal frontier
journal, April 2016

  • Reboldi, Andrea; Cyster, Jason G.
  • Immunological Reviews, Vol. 271, Issue 1
  • DOI: 10.1111/imr.12400

The impact of cell-bound antigen transport on mucosal tolerance induction
journal, June 2007

  • Pabst, Oliver; Bernhardt, Günter; Förster, Reinhold
  • Journal of Leukocyte Biology, Vol. 82, Issue 4
  • DOI: 10.1189/jlb.0307144

The 3′ Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells
journal, February 2012


IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches
journal, May 2016


Regulated Compartmentalization of Programmed Cell Death-1 Discriminates CD4 + CD25 + Resting Regulatory T Cells from Activated T Cells
journal, February 2006

  • Raimondi, Giorgio; Shufesky, William J.; Tokita, Daisuke
  • The Journal of Immunology, Vol. 176, Issue 5
  • DOI: 10.4049/jimmunol.176.5.2808

Foxp3-dependent programme of regulatory T-cell differentiation
journal, January 2007

  • Gavin, Marc A.; Rasmussen, Jeffrey P.; Fontenot, Jason D.
  • Nature, Vol. 445, Issue 7129
  • DOI: 10.1038/nature05543

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