Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Carr, Jessica A.; Franke, Daniel; Caram, Justin R.; Perkinson, Collin F.; Saif, Mari; Askoxylakis, Vasileios; Datta, Meenal; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G.; Bruns, Oliver T.

doi:10.1073/pnas.1718917115

Title: Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Journal Article · 05 April 2018 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.1718917115 · OSTI ID:1432122

^[1]; Franke, Daniel ^[1];

^[1]; Perkinson, Collin F. ^[1]; Saif, Mari ^[1]; Askoxylakis, Vasileios ^[2]; Datta, Meenal ^[3]; Fukumura, Dai ^[2]; Jain, Rakesh K. ^[2]; Bawendi, Moungi G. ^[1]; Bruns, Oliver T. ^[1]

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139,
Edwin L. Steele Labs for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, MGH Research Institute and Harvard Medical School, Boston, MA 02114,
Edwin L. Steele Labs for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, MGH Research Institute and Harvard Medical School, Boston, MA 02114,, Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155

Significance Imaging in the shortwave IR (SWIR) spectral window allows the observation of processes deep within living animals. Recent studies have shown that SWIR imaging enables unprecedented imaging opportunities, including contact-free monitoring of vital signs, generation of microvasculature blood flow maps, real-time metabolic imaging, and molecularly targeted imaging. Yet, whereas bright SWIR fluorophores have been developed for preclinical research settings, applications in the clinic have been held back by the conventional belief that no clinically approved fluorophore is available. Here, we show that indocyanine green, a clinically approved near-IR dye, exhibits a remarkable amount of SWIR emission, which enables state-of-the-art SWIR imaging with direct translation potential into clinical settings, and even outperforms other commercially available SWIR emitters.

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Research Organization:: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: FG02-07ER46454

OSTI ID:: 1432122

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 17 Vol. 115; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

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