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Title: Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly

Abstract

Nonionic fluorinated polyphosphazenes, such as poly[bis(trifluoroethoxy)phosphazene] (PTFEP), display superb biocompatibility, yet their deposition to surfaces has been limited to solution casting from organic solvents or thermal molding. Here in this paper, hydrophobic coatings of fluorinated polyphosphazenes are demonstrated through controlled deposition of ionic fluorinated polyphosphazenes (iFPs) from aqueous solutions using the layer-by-layer (LbL) technique. Specifically, the assemblies included poly[(carboxylatophenoxy)(trifluoroethoxy)phosphazenes] with varied content of fluorine atoms as iFPs (or poly[bis(carboxyphenoxy)phosphazene] (PCPP) as a control nonfluorinated polyphosphazene) and a variety of polycations. Hydrophobic interactions largely contributed to the formation of LbL films of iFPs with polycations, leading to linear growth and extremely low water uptake. Hydrophobicity-enhanced ionic pairing within iFP/BPEI assemblies gave rise to large-amplitude oscillations in surface wettability as a function of capping layer, which were the largest for the most fluorinated iFP, while control PCPP/polycation systems remained hydrophilic regardless of the film top layer. Neutron reflectometry (NR) studies indicated superior layering and persistence of such layering in salt solution for iFP/BPEI films as compared to control PCPP/polycation systems. Hydrophobicity of iFP-capped LbL coatings could be further enhanced by using a highly porous polyester surgical felt rather than planar substrates for film deposition. Importantly, iFP/polycation coatings displayed biocompatibility which was similarmore » to or superior to that of solution-cast coatings of a clinically validated material (PTFEP), as demonstrated by the hemolysis of the whole blood and protein adsorption studies.« less

Authors:
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [2];  [3];  [3]; ORCiD logo [1]
  1. Texas A & M Univ., College Station, TX (United States). Dept. of Materials Science & Engineering
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)
  3. Univ. of Maryland, Rockville, MD (United States). Inst. for Bioscience and Biotechnology Research
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF)
OSTI Identifier:
1430612
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Volume: 10; Journal Issue: 11; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Selin, Victor, Albright, Victoria, Ankner, John Francis, Marin, Alexander, Andrianov, Alexander K., and Sukhishvili, Svetlana A.. Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly. United States: N. p., 2018. Web. https://doi.org/10.1021/acsami.8b02072.
Selin, Victor, Albright, Victoria, Ankner, John Francis, Marin, Alexander, Andrianov, Alexander K., & Sukhishvili, Svetlana A.. Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly. United States. https://doi.org/10.1021/acsami.8b02072
Selin, Victor, Albright, Victoria, Ankner, John Francis, Marin, Alexander, Andrianov, Alexander K., and Sukhishvili, Svetlana A.. Fri . "Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly". United States. https://doi.org/10.1021/acsami.8b02072. https://www.osti.gov/servlets/purl/1430612.
@article{osti_1430612,
title = {Biocompatible Nanocoatings of Fluorinated Polyphosphazenes through Aqueous Assembly},
author = {Selin, Victor and Albright, Victoria and Ankner, John Francis and Marin, Alexander and Andrianov, Alexander K. and Sukhishvili, Svetlana A.},
abstractNote = {Nonionic fluorinated polyphosphazenes, such as poly[bis(trifluoroethoxy)phosphazene] (PTFEP), display superb biocompatibility, yet their deposition to surfaces has been limited to solution casting from organic solvents or thermal molding. Here in this paper, hydrophobic coatings of fluorinated polyphosphazenes are demonstrated through controlled deposition of ionic fluorinated polyphosphazenes (iFPs) from aqueous solutions using the layer-by-layer (LbL) technique. Specifically, the assemblies included poly[(carboxylatophenoxy)(trifluoroethoxy)phosphazenes] with varied content of fluorine atoms as iFPs (or poly[bis(carboxyphenoxy)phosphazene] (PCPP) as a control nonfluorinated polyphosphazene) and a variety of polycations. Hydrophobic interactions largely contributed to the formation of LbL films of iFPs with polycations, leading to linear growth and extremely low water uptake. Hydrophobicity-enhanced ionic pairing within iFP/BPEI assemblies gave rise to large-amplitude oscillations in surface wettability as a function of capping layer, which were the largest for the most fluorinated iFP, while control PCPP/polycation systems remained hydrophilic regardless of the film top layer. Neutron reflectometry (NR) studies indicated superior layering and persistence of such layering in salt solution for iFP/BPEI films as compared to control PCPP/polycation systems. Hydrophobicity of iFP-capped LbL coatings could be further enhanced by using a highly porous polyester surgical felt rather than planar substrates for film deposition. Importantly, iFP/polycation coatings displayed biocompatibility which was similar to or superior to that of solution-cast coatings of a clinically validated material (PTFEP), as demonstrated by the hemolysis of the whole blood and protein adsorption studies.},
doi = {10.1021/acsami.8b02072},
journal = {ACS Applied Materials and Interfaces},
number = 11,
volume = 10,
place = {United States},
year = {2018},
month = {2}
}

Journal Article:
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Figures / Tables:

Scheme 1 Scheme 1: Chemical Structures of the Components and Schematic Representation of the LbL Assembly

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