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Title: Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Abstract

Ion mobility (IM) is rapidly gaining attention for the separation and analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM separations have limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. Both of these can be readily obtained in Structures for Lossless Ion Manipulations (SLIM), which are fabricated from arrays of electrodes patterned on two parallel surfaces where potentials are applied to generate appropriate electric fields between the surfaces. Here we have investigated the relationship between the primary SLIM variables, such as electrode dimensions, inter-surface gap, and the applied TW voltages, that directly impact the fields experienced by ions. Ion trajectory simulations and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric fields on IM resolution. The variables explored impact both ion confinement and the observed IM resolution using SLIM modules.

Authors:
 [1];  [1];  [1];  [1]; ORCiD logo [1]
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  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1430526
Report Number(s):
PNNL-SA-127372
Journal ID: ISSN 1387-3806; PII: S1387380617303469
Grant/Contract Number:  
P41 GM103493; AC0576RL01830
Resource Type:
Accepted Manuscript
Journal Name:
International Journal of Mass Spectrometry
Additional Journal Information:
Journal Volume: 430; Journal Issue: C; Journal ID: ISSN 1387-3806
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Hamid, Ahmed M., Prabhakaran, Aneesh, Garimella, Sandilya V. B., Ibrahim, Yehia M., and Smith, Richard D. Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM). United States: N. p., 2018. Web. doi:10.1016/J.IJMS.2018.03.006.
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Hamid, Ahmed M., Prabhakaran, Aneesh, Garimella, Sandilya V. B., Ibrahim, Yehia M., & Smith, Richard D. Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM). United States. https://doi.org/10.1016/J.IJMS.2018.03.006
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Hamid, Ahmed M., Prabhakaran, Aneesh, Garimella, Sandilya V. B., Ibrahim, Yehia M., and Smith, Richard D. Mon . "Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)". United States. https://doi.org/10.1016/J.IJMS.2018.03.006. https://www.osti.gov/servlets/purl/1430526.
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@article{osti_1430526,
title = {Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)},
author = {Hamid, Ahmed M. and Prabhakaran, Aneesh and Garimella, Sandilya V. B. and Ibrahim, Yehia M. and Smith, Richard D.},
abstractNote = {Ion mobility (IM) is rapidly gaining attention for the separation and analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM separations have limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. Both of these can be readily obtained in Structures for Lossless Ion Manipulations (SLIM), which are fabricated from arrays of electrodes patterned on two parallel surfaces where potentials are applied to generate appropriate electric fields between the surfaces. Here we have investigated the relationship between the primary SLIM variables, such as electrode dimensions, inter-surface gap, and the applied TW voltages, that directly impact the fields experienced by ions. Ion trajectory simulations and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric fields on IM resolution. The variables explored impact both ion confinement and the observed IM resolution using SLIM modules.},
doi = {10.1016/J.IJMS.2018.03.006},
journal = {International Journal of Mass Spectrometry},
number = C,
volume = 430,
place = {United States},
year = {Mon Mar 26 00:00:00 EDT 2018},
month = {Mon Mar 26 00:00:00 EDT 2018}
}
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Journal Article:
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Publisher's Version of Record
https://doi.org/10.1016/J.IJMS.2018.03.006
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Cited by: 10 works
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Figures / Tables:

Figure 1: Part 1 Figure 1: Part 1: (A) Schematic diagram of the experimental setup. (B) Portion of a TW SLIM module surface using a 3,2 electrode arrangement of three RF electrodes interspersed by two segmented electrode arrays (used to create the TW) (C) Potential (black) and the field (red) due to TW onlymore » along x-axis in middle plane between the two boards for 2 mm electrode size and 2 mm intersurface gap. Region between points #1 to #2 represents one quarter of the wave which is equivalent to 2 electrodes distance, hence the average over this range represents the average field. (D) The plot of the equipotential surface generated by the RF pseudopotential for 622 m/z for a 2mm intersurface gap. The two surfaces are on the left and right.« less
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    Works referencing / citing this record:

    Recommendations for reporting ion mobility Mass Spectrometry measurements
    journal, October 2017

    • Gabelica, Valérie; Shvartsburg, Alexandre A.; Afonso, Carlos
    • Mass Spectrometry Reviews, Vol. 38, Issue 3
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    A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations
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    • Li, Ailin; Garimella, Sandilya V. B.; Ibrahim, Yehia M.
    • The Analyst, Vol. 145, Issue 1
    • DOI: 10.1039/c9an01509d
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      Figures / Tables found in this record:

      Figure 1: Part 1 (p. 16)figure
      Figure 1: Part 2 (p. 17)figure
      Figure 2 (p. 18)figure
      Figure 3 (p. 19)figure
      Figure 4 (p. 20)figure
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