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Title: Swapping of transmembrane domains in the epithelial calcium channel TRPV6

Journal Article · · Scientific Reports

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
NIH
OSTI ID:
1430345
Journal Information:
Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 7; ISSN 2045-2322
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
ENGLISH

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Cited By (19)

Structural insights on TRPV5 gating by endogenous modulators journal October 2018
Structural Insights on TRPV5 Gating by Endogenous Modulators journal February 2019
Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations journal November 2018
TRPV6 as A Target for Cancer Therapy journal January 2020
Structural insights on TRPV5 gating by endogenous modulators posted_content July 2018
Structure and gating mechanism of the transient receptor potential channel TRPV3 journal August 2018
Opening of the human epithelial calcium channel TRPV6 journal December 2017
Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations journal November 2018
A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine journal October 2018
New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question journal January 2019
X-ray crystallography of TRP channels journal January 2018
New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question journal January 2019
Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6 journal August 2018
Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy: Cryo-EM studies of ion channels journal March 2018
Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6 journal August 2018
Structural mechanisms of transient receptor potential ion channels journal January 2020
Structure and gating mechanism of the transient receptor potential channel TRPV3 journal August 2018
Structural insights on TRPV5 gating by endogenous modulators posted_content July 2018
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms journal February 2018

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