Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Abstract
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.
- Authors:
-
- Columbia Univ., New York, NY (United States)
- Publication Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- National Institutes of Health (NIH)
- OSTI Identifier:
- 1430345
- Grant/Contract Number:
- R01 NS083660; R01 CA206573; T32 GM008281
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Ion transport; Nanocrystallography
Citation Formats
Singh, Appu K., Saotome, Kei, and Sobolevsky, Alexander I. Swapping of transmembrane domains in the epithelial calcium channel TRPV6. United States: N. p., 2017.
Web. doi:10.1038/s41598-017-10993-9.
Singh, Appu K., Saotome, Kei, & Sobolevsky, Alexander I. Swapping of transmembrane domains in the epithelial calcium channel TRPV6. United States. https://doi.org/10.1038/s41598-017-10993-9
Singh, Appu K., Saotome, Kei, and Sobolevsky, Alexander I. Wed .
"Swapping of transmembrane domains in the epithelial calcium channel TRPV6". United States. https://doi.org/10.1038/s41598-017-10993-9. https://www.osti.gov/servlets/purl/1430345.
@article{osti_1430345,
title = {Swapping of transmembrane domains in the epithelial calcium channel TRPV6},
author = {Singh, Appu K. and Saotome, Kei and Sobolevsky, Alexander I.},
abstractNote = {Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.},
doi = {10.1038/s41598-017-10993-9},
journal = {Scientific Reports},
number = 1,
volume = 7,
place = {United States},
year = {2017},
month = {9}
}
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