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Title: Chemical copatterning strategies using azlactone-based block copolymers

Abstract

Interfaces can be modified with azlactone-functional polymers in order to manipulate the chemical surface reactivity. Azlactone groups are highly reactive toward amine, thiol, and alcohol nucleophiles, providing a versatile coupling chemistry for secondary surface modification. Azlactone-based surface polymers have been explored in numerous applications, including chemical and biological capture, sensing, and cell culture. These applications often require that the polymer is copatterned within a chemically or biologically inert background; however, common fabrication methods degrade azlactone groups during processing steps or result in polymer films with poorly controlled thicknesses. Here, the authors develop fabrication strategies using parylene lift-off and interface-directed assembly methods to generate microscale patterns of azlactone-based block copolymer in chemically or biologically inert backgrounds. The functionality of azlactone groups was preserved during fabrication, and patterned films appeared as uniform, 80–120nm brushlike films. The authors also develop a patterning approach that uses a novel microcontact stamping method to generate cross-linked, three-dimensional structures of azlactone-based polymers with controllable, microscale thicknesses. The authors identify the benefits of each approach and expect these polymers and patterning strategies to provide a versatile toolbox for developing synthetic interfaces with tuned chemical and physical features for sensing, cell culture, or material capture applications.

Authors:
 [1];  [1]; ORCiD logo [2]; ORCiD logo [2];  [1]
  1. Kansas State Univ., Manhattan, KS (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1427670
Alternate Identifier(s):
OSTI ID: 1378117
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Vacuum Science and Technology B
Additional Journal Information:
Journal Volume: 35; Journal Issue: 6; Journal ID: ISSN 2166-2746
Publisher:
American Vacuum Society/AIP
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Masigol, Mohammadali, Barua, Niloy, Retterer, Scott T., Lokitz, Bradley S., and Hansen, Ryan. Chemical copatterning strategies using azlactone-based block copolymers. United States: N. p., 2017. Web. doi:10.1116/1.4991881.
Masigol, Mohammadali, Barua, Niloy, Retterer, Scott T., Lokitz, Bradley S., & Hansen, Ryan. Chemical copatterning strategies using azlactone-based block copolymers. United States. https://doi.org/10.1116/1.4991881
Masigol, Mohammadali, Barua, Niloy, Retterer, Scott T., Lokitz, Bradley S., and Hansen, Ryan. Fri . "Chemical copatterning strategies using azlactone-based block copolymers". United States. https://doi.org/10.1116/1.4991881. https://www.osti.gov/servlets/purl/1427670.
@article{osti_1427670,
title = {Chemical copatterning strategies using azlactone-based block copolymers},
author = {Masigol, Mohammadali and Barua, Niloy and Retterer, Scott T. and Lokitz, Bradley S. and Hansen, Ryan},
abstractNote = {Interfaces can be modified with azlactone-functional polymers in order to manipulate the chemical surface reactivity. Azlactone groups are highly reactive toward amine, thiol, and alcohol nucleophiles, providing a versatile coupling chemistry for secondary surface modification. Azlactone-based surface polymers have been explored in numerous applications, including chemical and biological capture, sensing, and cell culture. These applications often require that the polymer is copatterned within a chemically or biologically inert background; however, common fabrication methods degrade azlactone groups during processing steps or result in polymer films with poorly controlled thicknesses. Here, the authors develop fabrication strategies using parylene lift-off and interface-directed assembly methods to generate microscale patterns of azlactone-based block copolymer in chemically or biologically inert backgrounds. The functionality of azlactone groups was preserved during fabrication, and patterned films appeared as uniform, 80–120nm brushlike films. The authors also develop a patterning approach that uses a novel microcontact stamping method to generate cross-linked, three-dimensional structures of azlactone-based polymers with controllable, microscale thicknesses. The authors identify the benefits of each approach and expect these polymers and patterning strategies to provide a versatile toolbox for developing synthetic interfaces with tuned chemical and physical features for sensing, cell culture, or material capture applications.},
doi = {10.1116/1.4991881},
journal = {Journal of Vacuum Science and Technology B},
number = 6,
volume = 35,
place = {United States},
year = {2017},
month = {9}
}

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