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Title: Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging

Mass spectrometry imaging is becoming an increasingly common analytical technique due to its ability to provide spatially resolved chemical information. In this paper, we report a novel imaging approach combining laser ablation with two mass spectrometric techniques, aerosol mass spectrometry and chemical ionization mass spectrometry, separately and in parallel. Both mass spectrometric methods provide the fast response, rapid data acquisition, low detection limits, and high-resolution peak separation desirable for imaging complex samples. Additionally, the two techniques provide complementary information with aerosol mass spectrometry providing near universal detection of all aerosol molecules and chemical ionization mass spectrometry with a heated inlet providing molecular-level detail of both gases and aerosols. The two techniques operate with atmospheric pressure interfaces and require no matrix addition for ionization, allowing for samples to be investigated in their native state under ambient pressure conditions. We demonstrate the ability of laser ablation-aerosol mass spectrometry-chemical ionization mass spectrometry (LA-AMS-CIMS) to create 2D images of both standard compounds and complex mixtures. Finally, the results suggest that LA-AMS-CIMS, particularly when combined with advanced data analysis methods, could have broad applications in mass spectrometry imaging applications.
Authors:
 [1] ;  [1] ;  [2] ;  [1] ;  [1] ;  [1] ;  [1] ; ORCiD logo [3] ; ORCiD logo [1] ; ORCiD logo [1]
  1. Univ. of Colorado, Boulder, CO (United States). Dept. of Chemistry and Biochemistry. Cooperative Inst. for Research in Environmental Sciences
  2. Univ. of Munster (Germany). Inst. of Inorganic and Analytical Chemistry
  3. Univ. of Colorado, Boulder, CO (United States). Dept. of Chemistry and Biochemistry. Cooperative Inst. for Research in Environmental Sciences; Univ. of Munster (Germany). Inst. of Inorganic and Analytical Chemistry
Publication Date:
Grant/Contract Number:
SC0016559; FP-91761701-0
Type:
Accepted Manuscript
Journal Name:
Analytical Chemistry
Additional Journal Information:
Journal Volume: 90; Journal Issue: 6; Journal ID: ISSN 0003-2700
Publisher:
American Chemical Society (ACS)
Research Org:
Univ. of Colorado, Boulder, CO (United States); Univ. of Munster (Germany)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); Univ. of Colorado (United States); USEPA; German Research Foundation (DFG)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; mass spectrometry imaging; aerosol mass spectrometry; chemical ionization mass spectrometry
OSTI Identifier:
1427500

Berry, Jennifer L., Day, Douglas A., Elseberg, Tim, Palm, Brett B., Hu, Weiwei, Abdelhamid, Aroob, Schroder, Jason C., Karst, Uwe, Jimenez, Jose L., and Browne, Eleanor C.. Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging. United States: N. p., Web. doi:10.1021/acs.analchem.7b05255.
Berry, Jennifer L., Day, Douglas A., Elseberg, Tim, Palm, Brett B., Hu, Weiwei, Abdelhamid, Aroob, Schroder, Jason C., Karst, Uwe, Jimenez, Jose L., & Browne, Eleanor C.. Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging. United States. doi:10.1021/acs.analchem.7b05255.
Berry, Jennifer L., Day, Douglas A., Elseberg, Tim, Palm, Brett B., Hu, Weiwei, Abdelhamid, Aroob, Schroder, Jason C., Karst, Uwe, Jimenez, Jose L., and Browne, Eleanor C.. 2018. "Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging". United States. doi:10.1021/acs.analchem.7b05255.
@article{osti_1427500,
title = {Laser Ablation-Aerosol Mass Spectrometry-Chemical Ionization Mass Spectrometry for Ambient Surface Imaging},
author = {Berry, Jennifer L. and Day, Douglas A. and Elseberg, Tim and Palm, Brett B. and Hu, Weiwei and Abdelhamid, Aroob and Schroder, Jason C. and Karst, Uwe and Jimenez, Jose L. and Browne, Eleanor C.},
abstractNote = {Mass spectrometry imaging is becoming an increasingly common analytical technique due to its ability to provide spatially resolved chemical information. In this paper, we report a novel imaging approach combining laser ablation with two mass spectrometric techniques, aerosol mass spectrometry and chemical ionization mass spectrometry, separately and in parallel. Both mass spectrometric methods provide the fast response, rapid data acquisition, low detection limits, and high-resolution peak separation desirable for imaging complex samples. Additionally, the two techniques provide complementary information with aerosol mass spectrometry providing near universal detection of all aerosol molecules and chemical ionization mass spectrometry with a heated inlet providing molecular-level detail of both gases and aerosols. The two techniques operate with atmospheric pressure interfaces and require no matrix addition for ionization, allowing for samples to be investigated in their native state under ambient pressure conditions. We demonstrate the ability of laser ablation-aerosol mass spectrometry-chemical ionization mass spectrometry (LA-AMS-CIMS) to create 2D images of both standard compounds and complex mixtures. Finally, the results suggest that LA-AMS-CIMS, particularly when combined with advanced data analysis methods, could have broad applications in mass spectrometry imaging applications.},
doi = {10.1021/acs.analchem.7b05255},
journal = {Analytical Chemistry},
number = 6,
volume = 90,
place = {United States},
year = {2018},
month = {2}
}