Recent Advances in Nanomaterials for Gene Delivery—A Review
Abstract
With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems.
- Authors:
-
- Univ. of Florida, Gainesville, FL (United States)
- Publication Date:
- Research Org.:
- Univ. of Florida, Gainesville, FL (United States)
- Sponsoring Org.:
- USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Bioenergy Technologies Office; USDOE Office of International Affairs (IA)
- OSTI Identifier:
- 1426434
- Alternate Identifier(s):
- OSTI ID: 1767999
- Grant/Contract Number:
- PI0000031
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nanomaterials
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 12; Journal ID: ISSN 2079-4991
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; gene delivery; nanomaterials; non-viral vectors; siRNA
Citation Formats
Riley, II, Michael K., and Vermerris, Wilfred. Recent Advances in Nanomaterials for Gene Delivery—A Review. United States: N. p., 2017.
Web. doi:10.3390/nano7050094.
Riley, II, Michael K., & Vermerris, Wilfred. Recent Advances in Nanomaterials for Gene Delivery—A Review. United States. https://doi.org/10.3390/nano7050094
Riley, II, Michael K., and Vermerris, Wilfred. Fri .
"Recent Advances in Nanomaterials for Gene Delivery—A Review". United States. https://doi.org/10.3390/nano7050094. https://www.osti.gov/servlets/purl/1426434.
@article{osti_1426434,
title = {Recent Advances in Nanomaterials for Gene Delivery—A Review},
author = {Riley, II, Michael K. and Vermerris, Wilfred},
abstractNote = {With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems.},
doi = {10.3390/nano7050094},
journal = {Nanomaterials},
number = 12,
volume = 7,
place = {United States},
year = {Fri Apr 28 00:00:00 EDT 2017},
month = {Fri Apr 28 00:00:00 EDT 2017}
}
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