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Title: Anion transport and supramolecular medicinal chemistry

Abstract

New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. The application of anion transporters to the potential future treatment of disease is discussed in the context of recent findings on the selectivity of anion transporters.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]
  1. Univ. of Sydney, NSW (Australia). School of Chemistry
  2. Univ. of Maryland, College Park, MD (United States). Dept. of Chemistry and Biochemistry
  3. Univ. of Burgos (Spain). Dept. of Chemistry
Publication Date:
Research Org.:
Univ. of Maryland, College Park, MD (United States); Univ. of Sydney, NSW (Australia); Univ. of Burgos (Spain)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); Australian Research Council; Ministry of Education of the Junta of Castile and Leon (Spain); La Marato de TV3 Foundation (Spain)
OSTI Identifier:
1425621
Grant/Contract Number:  
FG02-98ER14888; DP170100118; BU340U13; BU092U16; 20132730
Resource Type:
Accepted Manuscript
Journal Name:
Chemical Society Reviews
Additional Journal Information:
Journal Volume: 46; Journal Issue: 9; Journal ID: ISSN 0306-0012
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Gale, Philip A., Davis, Jeffery T., and Quesada, Roberto. Anion transport and supramolecular medicinal chemistry. United States: N. p., 2017. Web. doi:10.1039/c7cs00159b.
Gale, Philip A., Davis, Jeffery T., & Quesada, Roberto. Anion transport and supramolecular medicinal chemistry. United States. doi:10.1039/c7cs00159b.
Gale, Philip A., Davis, Jeffery T., and Quesada, Roberto. Wed . "Anion transport and supramolecular medicinal chemistry". United States. doi:10.1039/c7cs00159b. https://www.osti.gov/servlets/purl/1425621.
@article{osti_1425621,
title = {Anion transport and supramolecular medicinal chemistry},
author = {Gale, Philip A. and Davis, Jeffery T. and Quesada, Roberto},
abstractNote = {New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. The application of anion transporters to the potential future treatment of disease is discussed in the context of recent findings on the selectivity of anion transporters.},
doi = {10.1039/c7cs00159b},
journal = {Chemical Society Reviews},
number = 9,
volume = 46,
place = {United States},
year = {2017},
month = {4}
}

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Free Publicly Available Full Text
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Cited by: 68 works
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Works referenced in this record:

Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer
journal, February 2017

  • Rodilla, Ananda M.; Korrodi-Gregório, Luís; Hernando, Elsa
  • Biochemical Pharmacology, Vol. 126
  • DOI: 10.1016/j.bcp.2016.11.022

Preorganized Aryltriazole Foldamers as Effective Transmembrane Transporters for Chloride Anion
journal, July 2014

  • Shang, Jie; Si, Wen; Zhao, Wei
  • Organic Letters, Vol. 16, Issue 15
  • DOI: 10.1021/ol501772v

Chiral Selective Transmembrane Transport of Amino Acids through Artificial Channels
journal, January 2013

  • Chen, Lei; Si, Wen; Zhang, Liang
  • Journal of the American Chemical Society, Vol. 135, Issue 6
  • DOI: 10.1021/ja312704e

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro
journal, January 2016

  • Share, Andrew I.; Patel, Khushali; Nativi, Cristina
  • Chemical Communications, Vol. 52, Issue 48
  • DOI: 10.1039/C6CC03645G

The role of lipophilicity in transmembrane anion transport
journal, January 2012

  • Saggiomo, Vittorio; Otto, Sijbren; Marques, Igor
  • Chemical Communications, Vol. 48, Issue 43
  • DOI: 10.1039/c2cc31825c

Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport
journal, January 2014

  • Busschaert, Nathalie; Karagiannidis, Louise E.; Wenzel, Marco
  • Chemical Science, Vol. 5, Issue 3
  • DOI: 10.1039/c3sc52006d

A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells
journal, January 2016

  • Liu, Peng-Yun; Li, Shing-To; Shen, Fang-Fang
  • Chemical Communications, Vol. 52, Issue 46
  • DOI: 10.1039/C6CC01964A

Hopping-Mediated Anion Transport through a Mannitol-Based Rosette Ion Channel
journal, August 2014

  • Saha, Tanmoy; Dasari, Sathish; Tewari, Debanjan
  • Journal of the American Chemical Society, Vol. 136, Issue 40
  • DOI: 10.1021/ja506278z

Ditopic Ion Transport Systems: Anion-π Interactions and Halogen Bonds at Work
journal, October 2011

  • Vargas Jentzsch, Andreas; Emery, Daniel; Mareda, Jiri
  • Angewandte Chemie International Edition, Vol. 50, Issue 49
  • DOI: 10.1002/anie.201104966

Structure–Activity Relationships in Tripodal Transmembrane Anion Transporters: The Effect of Fluorination
journal, September 2011

  • Busschaert, Nathalie; Wenzel, Marco; Light, Mark E.
  • Journal of the American Chemical Society, Vol. 133, Issue 35
  • DOI: 10.1021/ja205884y

Experimental evidence for the functional relevance of anion–π interactions
journal, May 2010

  • Dawson, Ryan E.; Hennig, Andreas; Weimann, Dominik P.
  • Nature Chemistry, Vol. 2, Issue 7
  • DOI: 10.1038/nchem.657

Anion-π Slides for Transmembrane Transport
journal, January 2009


A fluorescent assay for chloride transport; identification of a synthetic anionophore with improved activity
journal, January 2005

  • McNally, Beth A.; Koulov, Atanas V.; Smith, Bradley D.
  • Chemical Communications, Issue 8
  • DOI: 10.1039/b414589e

A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells
journal, April 2012


Visualization and Quantification of Transmembrane Ion Transport into Giant Unilamellar Vesicles
journal, December 2014

  • Valkenier, Hennie; López Mora, Néstor; Kros, Alexander
  • Angewandte Chemie International Edition, Vol. 54, Issue 7
  • DOI: 10.1002/anie.201410200

Dynamic Covalent Transport of Amino Acids across Lipid Bilayers
journal, January 2015

  • Wu, Xin; Busschaert, Nathalie; Wells, Neil J.
  • Journal of the American Chemical Society, Vol. 137, Issue 4
  • DOI: 10.1021/ja510063n

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells
journal, December 2015

  • Soto-Cerrato, Vanessa; Manuel-Manresa, Pilar; Hernando, Elsa
  • Journal of the American Chemical Society, Vol. 137, Issue 50
  • DOI: 10.1021/jacs.5b09970

Squaramides as Potent Transmembrane Anion Transporters
journal, March 2012

  • Busschaert, Nathalie; Kirby, Isabelle L.; Young, Sarah
  • Angewandte Chemie International Edition, Vol. 51, Issue 18
  • DOI: 10.1002/anie.201200729

Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
journal, November 2015

  • Li, Hongyu; Valkenier, Hennie; Judd, Luke W.
  • Nature Chemistry, Vol. 8, Issue 1
  • DOI: 10.1038/nchem.2384

Cystic fibrosis
journal, May 2015

  • Ratjen, Felix; Bell, Scott C.; Rowe, Steven M.
  • Nature Reviews Disease Primers, Vol. 1, Issue 1
  • DOI: 10.1038/nrdp.2015.10

Chloride impermeability in cystic fibrosis
journal, February 1983


Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells
journal, August 2014

  • Ko, Sung-Kyun; Kim, Sung Kuk; Share, Andrew
  • Nature Chemistry, Vol. 6, Issue 10
  • DOI: 10.1038/nchem.2021

Towards “drug-like” indole-based transmembrane anion transporters
journal, January 2012

  • Moore, Stephen J.; Wenzel, Marco; Light, Mark E.
  • Chemical Science, Vol. 3, Issue 8
  • DOI: 10.1039/c2sc20551c

From molecule to malady
journal, March 2006


Transmembrane Halogen-Bonding Cascades
journal, March 2013

  • Vargas Jentzsch, Andreas; Matile, Stefan
  • Journal of the American Chemical Society, Vol. 135, Issue 14
  • DOI: 10.1021/ja4013276

Tripodal transmembrane transporters for bicarbonate
journal, January 2010

  • Busschaert, Nathalie; Gale, Philip A.; Haynes, Cally J. E.
  • Chemical Communications, Vol. 46, Issue 34
  • DOI: 10.1039/c0cc01684e

A Flexible Solution to Anion Transport: Powerful Anionophores Based on a Cyclohexane Scaffold
journal, April 2014

  • Cooper, James A.; Street, Steven T. G.; Davis, Anthony P.
  • Angewandte Chemie International Edition, Vol. 53, Issue 22
  • DOI: 10.1002/anie.201311071

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
journal, July 1993


Synthetic Prodiginine Obatoclax (GX15-070) and Related Analogues: Anion Binding, Transmembrane Transport, and Cytotoxicity Properties
journal, November 2011

  • Díaz de Greñu, Borja; Hernández, Paulina Iglesias; Espona, Margarita
  • Chemistry - A European Journal, Vol. 17, Issue 50
  • DOI: 10.1002/chem.201101547

Biotin[6]uril Esters: Chloride-Selective Transmembrane Anion Carriers Employing C—H···Anion Interactions
journal, April 2015

  • Lisbjerg, Micke; Valkenier, Hennie; Jessen, Bo M.
  • Journal of the American Chemical Society, Vol. 137, Issue 15
  • DOI: 10.1021/jacs.5b02306

Octafluorocalix[4]pyrrole: A Chloride/Bicarbonate Antiport Agent
journal, March 2010

  • Gale, Philip A.; Tong, Christine C.; Haynes, Cally J. E.
  • Journal of the American Chemical Society, Vol. 132, Issue 10
  • DOI: 10.1021/ja9092693

Tunable transmembrane chloride transport by bis-indolylureas
journal, January 2012

  • Haynes, Cally J. E.; Moore, Stephen J.; Hiscock, Jennifer R.
  • Chemical Science, Vol. 3, Issue 5
  • DOI: 10.1039/c2sc20041d

Strong Antibacterial Properties of Anion Transporters: A Result of Depolarization and Weakening of the Bacterial Membrane
journal, February 2015

  • Elie, Claude R.; David, Guillaume; Schmitzer, Andreea R.
  • Journal of Medicinal Chemistry, Vol. 58, Issue 5
  • DOI: 10.1021/jm501979f

Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
journal, January 2013

  • Busschaert, Nathalie; Bradberry, Samuel J.; Wenzel, Marco
  • Chemical Science, Vol. 4, Issue 8
  • DOI: 10.1039/c3sc51023a

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
journal, September 1989


Green fluorescent protein-based halide indicators with improved chloride and iodide affinities
journal, June 2001


A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations
journal, January 2017

  • Busschaert, Nathalie; Park, Seong-Hyun; Baek, Kyung-Hwa
  • Nature Chemistry, Vol. 9, Issue 7
  • DOI: 10.1038/NCHEM.2706

Nonprotonophoric Electrogenic Cl − Transport Mediated by Valinomycin-like Carriers
journal, July 2016


The ABC protein turned chloride channel whose failure causes cystic fibrosis
journal, March 2006

  • Gadsby, David C.; Vergani, Paola; Csanády, László
  • Nature, Vol. 440, Issue 7083
  • DOI: 10.1038/nature04712

Anion Transport with Chalcogen Bonds
journal, July 2016

  • Benz, Sebastian; Macchione, Mariano; Verolet, Quentin
  • Journal of the American Chemical Society, Vol. 138, Issue 29
  • DOI: 10.1021/jacs.6b05779

Ion Channels — Basic Science and Clinical Disease
journal, May 1997


Diaxial Diureido Decalins as Compact, Efficient, and Tunable Anion Transporters
journal, February 2011

  • Hussain, Sabir; Brotherhood, Peter R.; Judd, Luke W.
  • Journal of the American Chemical Society, Vol. 133, Issue 6
  • DOI: 10.1021/ja1076102

Persistent Organic Nanopores Amenable to Structural and Functional Tuning
journal, February 2016

  • Wei, Xiaoxi; Zhang, Guoqing; Shen, Yi
  • Journal of the American Chemical Society, Vol. 138, Issue 8
  • DOI: 10.1021/jacs.5b12698

Oligoether-Strapped Calix[4]pyrrole: An Ion-Pair Receptor Displaying Cation-Dependent Chloride Anion Transport
journal, February 2012

  • Park, In-Won; Yoo, Jaeduk; Kim, Bohyang
  • Chemistry - A European Journal, Vol. 18, Issue 9
  • DOI: 10.1002/chem.201103239

High-Affinity Anion Binding by Steroidal Squaramide Receptors
journal, February 2015

  • Edwards, Sophie J.; Valkenier, Hennie; Busschaert, Nathalie
  • Angewandte Chemie, Vol. 127, Issue 15
  • DOI: 10.1002/ange.201411805

A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule
journal, March 2005

  • Smith, David K.
  • Journal of Chemical Education, Vol. 82, Issue 3
  • DOI: 10.1021/ed082p393

pH switchable anion transport by an oxothiosquaramide
journal, January 2015

  • Elmes, Robert B. P.; Busschaert, Nathalie; Czech, Dawid D.
  • Chemical Communications, Vol. 51, Issue 50
  • DOI: 10.1039/C5CC03625A

Biological activity of synthetic ionophores: ion transporters as prospective drugs?
journal, January 2013

  • Alfonso, Ignacio; Quesada, Roberto
  • Chemical Science, Vol. 4, Issue 8
  • DOI: 10.1039/c3sc50882j

Lipophilic balance – a new design principle for transmembrane anion carriers
journal, January 2014

  • Valkenier, Hennie; Haynes, Cally J. E.; Herniman, Julie
  • Chemical Science, Vol. 5, Issue 3
  • DOI: 10.1039/c3sc52962b

Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues
journal, September 2005

  • Sessler, Jonathan L.; Eller, Leah R.; Cho, Won-Seob
  • Angewandte Chemie International Edition, Vol. 44, Issue 37
  • DOI: 10.1002/anie.200501740

Small-Molecule Uncoupling Protein Mimics: Synthetic Anion Receptors as Fatty Acid-Activated Proton Transporters
journal, December 2016

  • Wu, Xin; Gale, Philip A.
  • Journal of the American Chemical Society, Vol. 138, Issue 50
  • DOI: 10.1021/jacs.6b10615

Calix[4]pyrrole-based anion transporters with tuneable transport properties
journal, January 2010

  • Yano, Masafumi; Tong, Christine C.; Light, Mark E.
  • Organic & Biomolecular Chemistry, Vol. 8, Issue 19
  • DOI: 10.1039/c0ob00128g

pH-Regulated Nonelectrogenic Anion Transport by Phenylthiosemicarbazones
journal, June 2016

  • Howe, Ethan N. W.; Busschaert, Nathalie; Wu, Xin
  • Journal of the American Chemical Society, Vol. 138, Issue 26
  • DOI: 10.1021/jacs.6b04656

Anion transport across varying lipid membranes – the effect of lipophilicity
journal, January 2015

  • Spooner, Michael J.; Gale, Philip A.
  • Chemical Communications, Vol. 51, Issue 23
  • DOI: 10.1039/C5CC00823A

Chloride Transport through Supramolecular Barrel-Rosette Ion Channels: Lipophilic Control and Apoptosis-Inducing Activity
journal, December 2016

  • Saha, Tanmoy; Gautam, Amitosh; Mukherjee, Arnab
  • Journal of the American Chemical Society, Vol. 138, Issue 50
  • DOI: 10.1021/jacs.6b10379

Monoacylglycerols as transmembrane Cl− anion transporters
journal, January 2012

  • Bahmanjah, Soheila; Zhang, Ning; Davis, Jeffery T.
  • Chemical Communications, Vol. 48, Issue 37
  • DOI: 10.1039/c2cc18148g

Cardiac channelopathies
journal, January 2002


Dianilides of dipicolinic acid function as synthetic chloride channels
journal, January 2010

  • Yamnitz, Carl R.; Negin, Saeedeh; Carasel, I. Alexandru
  • Chemical Communications, Vol. 46, Issue 16
  • DOI: 10.1039/b924812a

Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies
journal, December 2016

  • Clarke, Harriet J.; Howe, Ethan N. W.; Wu, Xin
  • Journal of the American Chemical Society, Vol. 138, Issue 50
  • DOI: 10.1021/jacs.6b10694

Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding
journal, January 2014

  • Haynes, Cally J. E.; Busschaert, Nathalie; Kirby, Isabelle L.
  • Org. Biomol. Chem., Vol. 12, Issue 1
  • DOI: 10.1039/C3OB41522H

Transmembrane anion transport mediated by halogen-bond donors
journal, January 2012

  • Jentzsch, Andreas Vargas; Emery, Daniel; Mareda, Jiri
  • Nature Communications, Vol. 3, Issue 1
  • DOI: 10.1038/ncomms1902

Anion Receptor Chemistry
journal, September 2016


Structurally simple lipid bilayer transport agents for chloride and bicarbonate
journal, January 2011

  • Andrews, Natalie J.; Haynes, Cally J. E.; Light, Mark E.
  • Chem. Sci., Vol. 2, Issue 2
  • DOI: 10.1039/C0SC00503G

Ion channels versus ion pumps: the principal difference, in principle
journal, April 2009

  • Gadsby, David C.
  • Nature Reviews Molecular Cell Biology, Vol. 10, Issue 5
  • DOI: 10.1038/nrm2668

Quantification of Nitrate−π Interactions and Selective Transport of Nitrate Using Calix[4]pyrroles with Two Aromatic Walls
journal, May 2013

  • Adriaenssens, Louis; Estarellas, Carolina; Vargas Jentzsch, Andreas
  • Journal of the American Chemical Society, Vol. 135, Issue 22
  • DOI: 10.1021/ja4021793

    Works referencing / citing this record:

    Exploiting the Strong Hydrogen Bond Donor Properties of a Borinic Acid Functionality for Fluoride Anion Recognition
    journal, December 2017

    • Chen, Chang-Hong; Gabbaï, François P.
    • Angewandte Chemie International Edition, Vol. 57, Issue 2
    • DOI: 10.1002/anie.201709494

    Blockable Zn 10 L 15 Ion Channels through Subcomponent Self-Assembly
    journal, November 2017

    • Haynes, Cally J. E.; Zhu, Jinbo; Chimerel, Catalin
    • Angewandte Chemie International Edition, Vol. 56, Issue 48
    • DOI: 10.1002/anie.201709544

    Self-Assembly of an Anion-Binding Cryptand for the Selective Encapsulation, Sequestration, and Precipitation of Phosphate from Aqueous Systems
    journal, September 2018

    • Rice, Craig R.; Slater, Christopher; Faulkner, Robert A.
    • Angewandte Chemie International Edition, Vol. 57, Issue 40
    • DOI: 10.1002/anie.201805633

    Induced Fit of C 2 H 2 in a Flexible MOF Through Cooperative Action of Open Metal Sites
    journal, May 2019

    • Zeng, Heng; Xie, Mo; Huang, Yong-Liang
    • Angewandte Chemie International Edition, Vol. 58, Issue 25
    • DOI: 10.1002/anie.201904160

    pH-Dependent Chloride Transport by Pseudopeptidic Cages for the Selective Killing of Cancer Cells in Acidic Microenvironments
    journal, August 2019

    • Tapia, Lucía; Pérez, Yolanda; Bolte, Michael
    • Angewandte Chemie International Edition, Vol. 58, Issue 36
    • DOI: 10.1002/anie.201905965

    Voltage-Switchable HCl Transport Enabled by Lipid Headgroup-Transporter Interactions
    journal, August 2019

    • Wu, Xin; Small, Jennifer R.; Cataldo, Alessio
    • Angewandte Chemie International Edition, Vol. 58, Issue 42
    • DOI: 10.1002/anie.201907466

    Self-Assembly and C−H⋅⋅⋅Anion Hydrogen Bonding of Palladium(II)-based Metallacalixarenes Using Pyridyl- or Phenyl-Bridged Di-Naphthoimidazoles
    journal, October 2018

    • Deng, Wei; Yu, Zheng-Su; Liu, Xue-Hui
    • Chemistry - An Asian Journal, Vol. 13, Issue 21
    • DOI: 10.1002/asia.201801345

    Anion Recognition by a Bioactive Diureidodecalin Anionophore: Solid-State, Solution, and Computational Studies
    journal, May 2018

    • Jurček, Ondřej; Valkenier, Hennie; Puttreddy, Rakesh
    • Chemistry - A European Journal, Vol. 24, Issue 32
    • DOI: 10.1002/chem.201800537

    Synthesis and molecular structure of functionalized tris[2-(4′-substituted butoxyphenyl)]phosphine oxides as precursors of tripodal ligands
    journal, July 2018

    • Baulina, Tat'yana V.; Kudryavtsev, Igor Yu.; Smolyakov, Alexander F.
    • Heteroatom Chemistry, Vol. 29, Issue 4
    • DOI: 10.1002/hc.21454

    Steric influence of adamantane substitution in tris-urea receptor: encapsulation of sulphate and fluoride-water cluster
    journal, July 2018


    Fluorescent squaramides as anion receptors and transmembrane anion transporters
    journal, January 2018

    • Bao, Xiaoping; Wu, Xin; Berry, Stuart N.
    • Chemical Communications, Vol. 54, Issue 11
    • DOI: 10.1039/c7cc08706c

    Halide and hydroxide anion binding in water
    journal, January 2018

    • Savastano, M.; Bazzicalupi, C.; García-Gallarín, C.
    • Dalton Transactions, Vol. 47, Issue 10
    • DOI: 10.1039/c7dt04430e

    Evidence for anion-binding of all- cis hexafluorocyclohexane in solution and solid state
    journal, January 2018

    • Shyshov, Oleksandr; Siewerth, Kevin Andre; von Delius, Max
    • Chemical Communications, Vol. 54, Issue 34
    • DOI: 10.1039/c8cc01797b

    Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
    journal, January 2018

    • Marques, Igor; Costa, Pedro M. R.; Q. Miranda, Margarida
    • Physical Chemistry Chemical Physics, Vol. 20, Issue 32
    • DOI: 10.1039/c8cp02576b

    Novel self-adaptive boat-shaped complexes with a tetraphosphine ligand
    journal, January 2018

    • Yue, Kai; Guo, Yi-He; Pan, Jia-Qing
    • Dalton Transactions, Vol. 47, Issue 38
    • DOI: 10.1039/c8dt02498g

    1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters
    journal, January 2018

    • Bąk, Krzysztof M.; Chabuda, Krzysztof; Montes, Helena
    • Organic & Biomolecular Chemistry, Vol. 16, Issue 28
    • DOI: 10.1039/c8ob01031e

    Self-assembled orthoester cryptands: orthoester scope, post-functionalization, kinetic locking and tunable degradation kinetics
    journal, January 2018

    • Löw, Henrik; Mena-Osteritz, Elena; von Delius, Max
    • Chemical Science, Vol. 9, Issue 21
    • DOI: 10.1039/c8sc01750f

    Inhibition of autophagic flux by cyclometalated iridium( iii ) complexes through anion transportation
    journal, January 2019

    • Chen, Mu-He; Zheng, Yue; Cai, Xiong-Jie
    • Chemical Science, Vol. 10, Issue 11
    • DOI: 10.1039/c8sc04520h

    Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
    journal, January 2019

    • Spooner, Michael J.; Li, Hongyu; Marques, Igor
    • Chemical Science, Vol. 10, Issue 7
    • DOI: 10.1039/c8sc05155k

    Tuning the membrane permeability of polymersome nanoreactors developed by aqueous emulsion polymerization-induced self-assembly
    journal, January 2019

    • Varlas, Spyridon; Foster, Jeffrey C.; Georgiou, Panagiotis G.
    • Nanoscale, Vol. 11, Issue 26
    • DOI: 10.1039/c9nr02507c

    Triaminopyrimidine derivatives as transmembrane HCl transporters
    journal, January 2019

    • Motloch, Petr; Guerreiro, Ana; Azeredo, Carolina Q.
    • Organic & Biomolecular Chemistry, Vol. 17, Issue 22
    • DOI: 10.1039/c9ob00725c

    Selective recognition of small hydrogen bond acceptors by a calix[6]arene-based molecular container
    journal, October 2019


    The hallmarks of living systems: towards creating artificial cells
    journal, August 2018

    • Yewdall, N. Amy; Mason, Alexander F.; van Hest, Jan C. M.
    • Interface Focus, Vol. 8, Issue 5
    • DOI: 10.1098/rsfs.2018.0023

    Exploiting the Strong Hydrogen Bond Donor Properties of a Borinic Acid Functionality for Fluoride Anion Recognition
    journal, December 2017

    • Chen, Chang-Hong; Gabbaï, François P.
    • Angewandte Chemie International Edition, Vol. 57, Issue 2
    • DOI: 10.1002/anie.201709494

    Blockable Zn 10 L 15 Ion Channels through Subcomponent Self-Assembly
    journal, November 2017

    • Haynes, Cally J. E.; Zhu, Jinbo; Chimerel, Catalin
    • Angewandte Chemie International Edition, Vol. 56, Issue 48
    • DOI: 10.1002/anie.201709544

    Self-Assembly of an Anion-Binding Cryptand for the Selective Encapsulation, Sequestration, and Precipitation of Phosphate from Aqueous Systems
    journal, September 2018

    • Rice, Craig R.; Slater, Christopher; Faulkner, Robert A.
    • Angewandte Chemie International Edition, Vol. 57, Issue 40
    • DOI: 10.1002/anie.201805633

    Induced Fit of C 2 H 2 in a Flexible MOF Through Cooperative Action of Open Metal Sites
    journal, May 2019

    • Zeng, Heng; Xie, Mo; Huang, Yong-Liang
    • Angewandte Chemie International Edition, Vol. 58, Issue 25
    • DOI: 10.1002/anie.201904160

    pH-Dependent Chloride Transport by Pseudopeptidic Cages for the Selective Killing of Cancer Cells in Acidic Microenvironments
    journal, August 2019

    • Tapia, Lucía; Pérez, Yolanda; Bolte, Michael
    • Angewandte Chemie International Edition, Vol. 58, Issue 36
    • DOI: 10.1002/anie.201905965

    Voltage-Switchable HCl Transport Enabled by Lipid Headgroup-Transporter Interactions
    journal, August 2019

    • Wu, Xin; Small, Jennifer R.; Cataldo, Alessio
    • Angewandte Chemie International Edition, Vol. 58, Issue 42
    • DOI: 10.1002/anie.201907466

    Self-Assembly and C−H⋅⋅⋅Anion Hydrogen Bonding of Palladium(II)-based Metallacalixarenes Using Pyridyl- or Phenyl-Bridged Di-Naphthoimidazoles
    journal, October 2018

    • Deng, Wei; Yu, Zheng-Su; Liu, Xue-Hui
    • Chemistry - An Asian Journal, Vol. 13, Issue 21
    • DOI: 10.1002/asia.201801345

    Anion Recognition by a Bioactive Diureidodecalin Anionophore: Solid-State, Solution, and Computational Studies
    journal, May 2018

    • Jurček, Ondřej; Valkenier, Hennie; Puttreddy, Rakesh
    • Chemistry - A European Journal, Vol. 24, Issue 32
    • DOI: 10.1002/chem.201800537

    Synthesis and molecular structure of functionalized tris[2-(4′-substituted butoxyphenyl)]phosphine oxides as precursors of tripodal ligands
    journal, July 2018

    • Baulina, Tat'yana V.; Kudryavtsev, Igor Yu.; Smolyakov, Alexander F.
    • Heteroatom Chemistry, Vol. 29, Issue 4
    • DOI: 10.1002/hc.21454

    Steric influence of adamantane substitution in tris-urea receptor: encapsulation of sulphate and fluoride-water cluster
    journal, July 2018


    Fluorescent squaramides as anion receptors and transmembrane anion transporters
    journal, January 2018

    • Bao, Xiaoping; Wu, Xin; Berry, Stuart N.
    • Chemical Communications, Vol. 54, Issue 11
    • DOI: 10.1039/c7cc08706c

    Halide and hydroxide anion binding in water
    journal, January 2018

    • Savastano, M.; Bazzicalupi, C.; García-Gallarín, C.
    • Dalton Transactions, Vol. 47, Issue 10
    • DOI: 10.1039/c7dt04430e

    Anion-coordination-directed self-assemblies
    journal, January 2018

    • Yang, Dong; Zhao, Jie; Yang, Xiao-Juan
    • Organic Chemistry Frontiers, Vol. 5, Issue 4
    • DOI: 10.1039/c7qo00895c

    Evidence for anion-binding of all- cis hexafluorocyclohexane in solution and solid state
    journal, January 2018

    • Shyshov, Oleksandr; Siewerth, Kevin Andre; von Delius, Max
    • Chemical Communications, Vol. 54, Issue 34
    • DOI: 10.1039/c8cc01797b

    Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
    journal, January 2018

    • Marques, Igor; Costa, Pedro M. R.; Q. Miranda, Margarida
    • Physical Chemistry Chemical Physics, Vol. 20, Issue 32
    • DOI: 10.1039/c8cp02576b

    Novel self-adaptive boat-shaped complexes with a tetraphosphine ligand
    journal, January 2018

    • Yue, Kai; Guo, Yi-He; Pan, Jia-Qing
    • Dalton Transactions, Vol. 47, Issue 38
    • DOI: 10.1039/c8dt02498g

    1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters
    journal, January 2018

    • Bąk, Krzysztof M.; Chabuda, Krzysztof; Montes, Helena
    • Organic & Biomolecular Chemistry, Vol. 16, Issue 28
    • DOI: 10.1039/c8ob01031e

    Self-assembled orthoester cryptands: orthoester scope, post-functionalization, kinetic locking and tunable degradation kinetics
    journal, January 2018

    • Löw, Henrik; Mena-Osteritz, Elena; von Delius, Max
    • Chemical Science, Vol. 9, Issue 21
    • DOI: 10.1039/c8sc01750f

    Inhibition of autophagic flux by cyclometalated iridium( iii ) complexes through anion transportation
    journal, January 2019

    • Chen, Mu-He; Zheng, Yue; Cai, Xiong-Jie
    • Chemical Science, Vol. 10, Issue 11
    • DOI: 10.1039/c8sc04520h

    Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
    journal, January 2019

    • Spooner, Michael J.; Li, Hongyu; Marques, Igor
    • Chemical Science, Vol. 10, Issue 7
    • DOI: 10.1039/c8sc05155k

    Tuning the membrane permeability of polymersome nanoreactors developed by aqueous emulsion polymerization-induced self-assembly
    journal, January 2019

    • Varlas, Spyridon; Foster, Jeffrey C.; Georgiou, Panagiotis G.
    • Nanoscale, Vol. 11, Issue 26
    • DOI: 10.1039/c9nr02507c

    Triaminopyrimidine derivatives as transmembrane HCl transporters
    journal, January 2019

    • Motloch, Petr; Guerreiro, Ana; Azeredo, Carolina Q.
    • Organic & Biomolecular Chemistry, Vol. 17, Issue 22
    • DOI: 10.1039/c9ob00725c

    Selective recognition of small hydrogen bond acceptors by a calix[6]arene-based molecular container
    journal, October 2019


    The hallmarks of living systems: towards creating artificial cells
    journal, August 2018

    • Yewdall, N. Amy; Mason, Alexander F.; van Hest, Jan C. M.
    • Interface Focus, Vol. 8, Issue 5
    • DOI: 10.1098/rsfs.2018.0023

    Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles
    journal, January 2020

    • Torres-Huerta, Aaron; Chan, Tiffany G.; White, Andrew J. P.
    • Dalton Transactions, Vol. 49, Issue 18
    • DOI: 10.1039/d0dt00930j

    Switchable foldamer ion channels with antibacterial activity
    journal, January 2020

    • Peters, Anna D.; Borsley, Stefan; della Sala, Flavio
    • Chemical Science
    • DOI: 10.1039/d0sc02393k

    Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties
    journal, January 2020

    • Zhou, Benyu; Gabbaï, François P.
    • Chemical Science, Vol. 11, Issue 28
    • DOI: 10.1039/d0sc02872j

    A tripodal tris-selenourea anion transporter matches the activity of its thio- analogue but shows distinct selectivity
    journal, February 2018