skip to main content

DOE PAGESDOE PAGES

This content will become publicly available on March 1, 2019

Title: Pharmacokinetics of [ 14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of complex PAH mixtures. PAH relative potency factors (RPFs, BaP=1) are determined from high dose animal data. Here we employed accelerator mass spectrometry (AMS) to determine pharmacokinetics of [ 14C]-BaP in humans following dosing with 46 ng (an order of magnitude lower than human dietary daily exposure and million-fold lower than animal cancer models). To assess the impact of co-administration of food with a complex PAH mixture, humans were dosed with 46 ng of [ 14C]-BaP with or without smoked salmon. Subjects were asked to avoid high BaP-containing diets and a 3-day dietary questionnaire given to assess dietary exposure prior to dosing and three days post-dosing with [ 14C]-BaP. Co-administration of smoked salmon, containing a complex mixture of PAHs with an RPF of 460 ng BaP eq, reduced and delayed absorption. Administration of canned commercial salmon, containing very low amounts of PAHs, showed the impacts on pharmacokinetics were not due to high amounts of PAHs but rather a food matrix effect.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [4] ;  [2] ;  [5] ;  [6] ;  [6] ;  [4] ;  [7] ;  [8] ;  [2] ;  [2] ;  [3]
  1. Oregon State Univ., Corvallis, OR (United States). Dept. of Nutrition and Dietetics, and Superfund Research Program
  2. Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Oregon State Univ., Corvallis, OR (United States). Dept. of Environmental and Molecular Toxicology
  3. Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Oregon State Univ., Corvallis, OR (United States). Dept. of Environmental and Molecular Toxicology; Oregon State Univ., Corvallis, OR (United States). Linus Pauling Inst.
  4. Oregon State Univ., Corvallis, OR (United States). Linus Pauling Inst.
  5. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biosciences and Biotechnology Division
  6. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Center for Accelerator Mass Spectrometry
  7. Confederated Tribes of the Umatilla Indian Reservation, Pendelton, OR (United States). Nixyaawii Governance Center
  8. Oregon State Univ., Corvallis, OR (United States). Superfund Research Program; Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Chemical Biology and Exposure Science
Publication Date:
Report Number(s):
PNNL-SA-132485
Journal ID: ISSN 0278-6915; PII: S027869151830142X
Grant/Contract Number:
AC0576RL01830; AC52-07NA27344; P42ES016465; R01ES028600; P41GM103483; T32ES07060
Type:
Accepted Manuscript
Journal Name:
Food and Chemical Toxicology
Additional Journal Information:
Journal Volume: 115; Journal ID: ISSN 0278-6915
Publisher:
Elsevier
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE; National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Pharmacokinetics; Benzo[a]pyrene; Accelerator mass spectrometry; Dietary polycyclic aromatic hydrocarbons
OSTI Identifier:
1425498