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Title: The 3′ UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor

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Predoctoral GAANN Fellowship #P200A150131
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Published Article
Journal Name:
Frontiers in Cellular Neuroscience
Additional Journal Information:
Journal Name: Frontiers in Cellular Neuroscience Journal Volume: 12; Journal ID: ISSN 1662-5102
Frontiers Media SA
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Country unknown/Code not available

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O’Neill, Kate M., Donohue, Katherine E., Omelchenko, Anton, and Firestein, Bonnie L. The 3′ UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor. Country unknown/Code not available: N. p., 2018. Web. doi:10.3389/fncel.2018.00060.
O’Neill, Kate M., Donohue, Katherine E., Omelchenko, Anton, & Firestein, Bonnie L. The 3′ UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor. Country unknown/Code not available. doi:10.3389/fncel.2018.00060.
O’Neill, Kate M., Donohue, Katherine E., Omelchenko, Anton, and Firestein, Bonnie L. Wed . "The 3′ UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor". Country unknown/Code not available. doi:10.3389/fncel.2018.00060.
title = {The 3′ UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor},
author = {O’Neill, Kate M. and Donohue, Katherine E. and Omelchenko, Anton and Firestein, Bonnie L.},
abstractNote = {},
doi = {10.3389/fncel.2018.00060},
journal = {Frontiers in Cellular Neuroscience},
number = ,
volume = 12,
place = {Country unknown/Code not available},
year = {2018},
month = {3}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.3389/fncel.2018.00060

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Cited by: 1 work
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Works referenced in this record:

Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95
journal, October 2006

BDNF-Promoted Increases in Proximal Dendrites Occur via CREB-Dependent Transcriptional Regulation of Cypin
journal, June 2011

Activity-dependent regulation of dendritic growth and patterning
journal, October 2002

  • Wong, Rachel O. L.; Ghosh, Anirvan
  • Nature Reviews Neuroscience, Vol. 3, Issue 10
  • DOI: 10.1038/nrn941

Activity-Dependent Dendritic Release of BDNF and Biological Consequences
journal, January 2009

  • Kuczewski, Nicola; Porcher, Christophe; Lessmann, Volkmar
  • Molecular Neurobiology, Vol. 39, Issue 1
  • DOI: 10.1007/s12035-009-8050-7

Neurotrophin regulation of neural circuit development and function
journal, December 2012

  • Park, Hyungju; Poo, Mu-ming
  • Nature Reviews Neuroscience, Vol. 14, Issue 1
  • DOI: 10.1038/nrn3379

Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)
journal, August 2010

  • Lau, A. G.; Irier, H. A.; Gu, J.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 36
  • DOI: 10.1073/pnas.1002929107

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
journal, January 2006

Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales
journal, January 2010

  • Kutzing, Melinda K.; Langhammer, Christopher G.; Luo, Vincent
  • Journal of Visualized Experiments, Issue 45
  • DOI: 10.3791/2354

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease
journal, April 2005

  • Liu, Qing-Rong; Walther, Donna; Drgon, Tomas
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 134B, Issue 1
  • DOI: 10.1002/ajmg.b.30109

BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways
journal, January 2004

  • Dijkhuizen, Paul A.; Ghosh, Anirvan
  • Journal of Neurobiology, Vol. 62, Issue 2
  • DOI: 10.1002/neu.20100

Brain-derived neurotrophic factor produced by human umbilical tissue-derived cells is required for its effect on hippocampal dendritic differentiation
journal, May 2012

  • Alder, Janet; Kramer, Brian C.; Hoskin, Casey
  • Developmental Neurobiology, Vol. 72, Issue 6
  • DOI: 10.1002/dneu.20980

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
journal, May 2011

  • Cazorla, Maxime; Prémont, Joël; Mann, Andre
  • Journal of Clinical Investigation, Vol. 121, Issue 5
  • DOI: 10.1172/JCI43992

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation
journal, September 2009

  • Chiaruttini, C.; Vicario, A.; Li, Z.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 38
  • DOI: 10.1073/pnas.0902833106

BDNF release from single cells elicits local dendritic growth in nearby neurons
journal, September 2002

  • Horch, Hadley Wilson; Katz, Lawrence C.
  • Nature Neuroscience, Vol. 5, Issue 11
  • DOI: 10.1038/nn927

Automated Sholl analysis of digitized neuronal morphology at multiple scales: Whole cell Sholl analysis versus Sholl analysis of arbor subregions
journal, November 2010

  • Langhammer, Christopher G.; Previtera, Michelle L.; Sweet, Eric S.
  • Cytometry Part A, Vol. 77A, Issue 12
  • DOI: 10.1002/cyto.a.20954

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
journal, January 2009

Autocrine BDNF–TrkB signalling within a single dendritic spine
journal, September 2016

  • Harward, Stephen C.; Hedrick, Nathan G.; Hall, Charles E.
  • Nature, Vol. 538, Issue 7623
  • DOI: 10.1038/nature19766

Distinct effects on the dendritic arbor occur by microbead versus bath administration of brain-derived neurotrophic factor
journal, July 2017

  • O’Neill, Kate M.; Kwon, Munjin; Donohue, Katherine E.
  • Cellular and Molecular Life Sciences, Vol. 74, Issue 23
  • DOI: 10.1007/s00018-017-2589-7

Destabilization of Cortical Dendrites and Spines by BDNF
journal, June 1999

Neurotrophins regulate dendritic growth in developing visual cortex
journal, October 1995

journal, November 1999

Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins
journal, October 2015

  • Vicario, Annalisa; Colliva, Andrea; Ratti, Antonia
  • Frontiers in Molecular Neuroscience, Vol. 8
  • DOI: 10.3389/fnmol.2015.00062

Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments
journal, September 2011

  • Baj, G.; Leone, E.; Chao, M. V.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 40
  • DOI: 10.1073/pnas.1014168108

Dendritic arbor development and synaptogenesis
journal, February 2001

Multiple functions for the cadherin/catenin complex during neuronal development
journal, October 2004

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
journal, September 2009

Signaling pathways controlling activity-dependent local translation of BDNF and their localization in dendritic arbors
journal, June 2016

  • Baj, Gabriele; Pinhero, Vera; Vaghi, Valentina
  • Journal of Cell Science, Vol. 129, Issue 14
  • DOI: 10.1242/jcs.177626

Multiple promoters direct tissue-specific expression of the rat BDNF gene
journal, March 1993

Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus
journal, March 2017

  • Maynard, Kristen R.; Hobbs, John W.; Sukumar, Mahima
  • Brain Structure and Function, Vol. 222, Issue 7
  • DOI: 10.1007/s00429-017-1405-3

Dendritic mRNA: transport, translation and function
journal, October 2007

  • Bramham, Clive R.; Wells, David G.
  • Nature Reviews Neuroscience, Vol. 8, Issue 10
  • DOI: 10.1038/nrn2150

Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
journal, March 2012

  • Liao, Guey-Ying; An, Juan Ji; Gharami, Kusumika
  • Nature Medicine, Vol. 18, Issue 4
  • DOI: 10.1038/nm.2687

Mouse and ratBDNF gene structure and expression revisited
journal, January 2007

  • Aid, Tamara; Kazantseva, Anna; Piirsoo, Marko
  • Journal of Neuroscience Research, Vol. 85, Issue 3
  • DOI: 10.1002/jnr.21139

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.
journal, October 1993

  • Metsis, M.; Timmusk, T.; Arenas, E.
  • Proceedings of the National Academy of Sciences, Vol. 90, Issue 19
  • DOI: 10.1073/pnas.90.19.8802

Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA: OFQ Inhibits Dendrite Growth via RhoA
journal, August 2013

  • Alder, Janet; Kallman, Seth; Palmieri, Alicia
  • Developmental Neurobiology, Vol. 73, Issue 10
  • DOI: 10.1002/dneu.22101

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons
journal, July 2008

BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching
journal, April 2013

Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
journal, December 1996

HuD Interacts with Bdnf mRNA and Is Essential for Activity-Induced BDNF Synthesis in Dendrites
journal, February 2015

Pharmacological Profile of Brain-derived Neurotrophic Factor ( BDNF ) Splice Variant Translation Using a Novel Drug Screening Assay : A “QUANTITATIVE CODE”
journal, July 2014

  • Vaghi, Valentina; Polacchini, Alessio; Baj, Gabriele
  • Journal of Biological Chemistry, Vol. 289, Issue 40
  • DOI: 10.1074/jbc.M114.586719

Assessing effects on dendritic arborization using novel Sholl analyses
journal, July 2015

  • O'Neill, Kate M.; Akum, Barbara F.; Dhawan, Survandita T.
  • Frontiers in Cellular Neuroscience, Vol. 9
  • DOI: 10.3389/fncel.2015.00285

Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
journal, November 1998

Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
journal, April 2000

  • Yacoubian, Talene A.; Lo, Donald C.
  • Nature Neuroscience, Vol. 3, Issue 4
  • DOI: 10.1038/73911