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Title: Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)

Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ; ORCiD logo [2] ;  [1]
  1. Univ. of Pittsburgh, PA (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. de Lisbo, Lisboa (Portugal)
Publication Date:
Report Number(s):
LA-UR-18-20169
Journal ID: ISSN 1932-6203
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Volume: 13; Journal Issue: 2; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
National Institutes of Health (NIH); USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Biological Science
OSTI Identifier:
1423983

Policicchio, Benjamin Bruno, Sette, Paola, Xu, Cuiling, Haret-Richter, George, Dunsmore, Tammy, Pandrea, Ivona, Ribeiro, Ruy Miguel, and Apetrei, Cristian. Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART). United States: N. p., Web. doi:10.1371/journal.pone.0190908.
Policicchio, Benjamin Bruno, Sette, Paola, Xu, Cuiling, Haret-Richter, George, Dunsmore, Tammy, Pandrea, Ivona, Ribeiro, Ruy Miguel, & Apetrei, Cristian. Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART). United States. doi:10.1371/journal.pone.0190908.
Policicchio, Benjamin Bruno, Sette, Paola, Xu, Cuiling, Haret-Richter, George, Dunsmore, Tammy, Pandrea, Ivona, Ribeiro, Ruy Miguel, and Apetrei, Cristian. 2018. "Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)". United States. doi:10.1371/journal.pone.0190908. https://www.osti.gov/servlets/purl/1423983.
@article{osti_1423983,
title = {Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)},
author = {Policicchio, Benjamin Bruno and Sette, Paola and Xu, Cuiling and Haret-Richter, George and Dunsmore, Tammy and Pandrea, Ivona and Ribeiro, Ruy Miguel and Apetrei, Cristian},
abstractNote = {Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation},
doi = {10.1371/journal.pone.0190908},
journal = {PLoS ONE},
number = 2,
volume = 13,
place = {United States},
year = {2018},
month = {2}
}