A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip

Wang, Hanfeng; Britton, Charles; Quaiyum, Farhan; Pullano, Salvatore A.; Taylor, Logan; Fiorillo, Antonino S.; Islam, Syed K.

doi:10.1109/TCSII.2018.2798929

Title: A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip

Abstract

With increasing emphasis on implantable and portable medical devices, low-power, small-chip-area sensor readout system realized in lab-on-a-chip (LOC) platform is gaining more and more importance these days. The main building blocks of the LOC system include a front-end transducer that generates an electrical signal in response to the presence of an analyte of interest, signal processing electronics to process the signal to comply with a specific transmission protocol and a low-power transmitter, all realized in a single integrated circuit platform. Low power consumption and compactness of the components are essential requirements of the LOC system. This paper presents a novel charge sensitive pre-amplifier developed in a standard 180-nm CMOS process suitable for implementing in an LOC platform. The pre-amplifier converts the charge generated by a pyroelectric transducer into a voltage signal, which provides a measurement of the temperature variation in biological fluids. The proposed design is capable of providing 0.8-mV/pC gain while consuming only 2.1 μW of power. Finally, the pre-amplifier composed of integrated components occupies an area of 0.038 mm².

Authors:

Wang, Hanfeng ^[1]; Britton, Charles ^[2]; Quaiyum, Farhan ^[1]; Pullano, Salvatore A. ^[3]; Taylor, Logan ^[1]; Fiorillo, Antonino S. ^[3]; Islam, Syed K. ^[1]

Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
Magna Graecia Univ., Catanzaro (Italy). School of Biomedical Engineering. Dept. of Health Sciences

Publication Date:: Fri Jan 26 00:00:00 EST 2018

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1422600

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: IEEE Transactions on Circuits and Systems. II, Express Briefs

Additional Journal Information:: Journal Volume: 65; Journal Issue: 8; Journal ID: ISSN 1549-7747

Publisher:: IEEE

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; charge amplifier; lab-on-a-chip (LOC); pyroelectric materials; PVDF; CMOS technology

Citation Formats


                    Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., and Islam, Syed K. A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip.  United States: N. p., 2018. 
Web.  doi:10.1109/TCSII.2018.2798929.

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                    Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., & Islam, Syed K. A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip.  United States.  https://doi.org/10.1109/TCSII.2018.2798929

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                    Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., and Islam, Syed K. Fri .  
"A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip".  United States.  https://doi.org/10.1109/TCSII.2018.2798929.  https://www.osti.gov/servlets/purl/1422600.

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@article{osti_1422600,

  title        = {A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip},

  author       = {Wang, Hanfeng and Britton, Charles and Quaiyum, Farhan and Pullano, Salvatore A. and Taylor, Logan and Fiorillo, Antonino S. and Islam, Syed K.},

  abstractNote = {With increasing emphasis on implantable and portable medical devices, low-power, small-chip-area sensor readout system realized in lab-on-a-chip (LOC) platform is gaining more and more importance these days. The main building blocks of the LOC system include a front-end transducer that generates an electrical signal in response to the presence of an analyte of interest, signal processing electronics to process the signal to comply with a specific transmission protocol and a low-power transmitter, all realized in a single integrated circuit platform. Low power consumption and compactness of the components are essential requirements of the LOC system. This paper presents a novel charge sensitive pre-amplifier developed in a standard 180-nm CMOS process suitable for implementing in an LOC platform. The pre-amplifier converts the charge generated by a pyroelectric transducer into a voltage signal, which provides a measurement of the temperature variation in biological fluids. The proposed design is capable of providing 0.8-mV/pC gain while consuming only 2.1 μW of power. Finally, the pre-amplifier composed of integrated components occupies an area of 0.038 mm2.},

  doi          = {10.1109/TCSII.2018.2798929},

  journal      = {IEEE Transactions on Circuits and Systems. II, Express Briefs},

  number       = 8,

  volume       = 65,

  place        = {United States},

  year         = {Fri Jan 26 00:00:00 EST 2018},

  month        = {Fri Jan 26 00:00:00 EST 2018}

}

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Journal Article:

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https://doi.org/10.1109/TCSII.2018.2798929

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Fig. 1: Schematic diagram of a basic charge amplifier.

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