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Title: A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip

Abstract

With increasing emphasis on implantable and portable medical devices, low-power, small-chip-area sensor readout system realized in lab-on-a-chip (LOC) platform is gaining more and more importance these days. The main building blocks of the LOC system include a front-end transducer that generates an electrical signal in response to the presence of an analyte of interest, signal processing electronics to process the signal to comply with a specific transmission protocol and a low-power transmitter, all realized in a single integrated circuit platform. Low power consumption and compactness of the components are essential requirements of the LOC system. This paper presents a novel charge sensitive pre-amplifier developed in a standard 180-nm CMOS process suitable for implementing in an LOC platform. The pre-amplifier converts the charge generated by a pyroelectric transducer into a voltage signal, which provides a measurement of the temperature variation in biological fluids. The proposed design is capable of providing 0.8-mV/pC gain while consuming only 2.1 μW of power. Finally, the pre-amplifier composed of integrated components occupies an area of 0.038 mm2.

Authors:
 [1];  [2];  [1];  [3];  [1];  [3];  [1]
  1. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
  3. Magna Graecia Univ., Catanzaro (Italy). School of Biomedical Engineering. Dept. of Health Sciences
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1422600
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
IEEE Transactions on Circuits and Systems. II, Express Briefs
Additional Journal Information:
Journal Volume: 65; Journal Issue: 8; Journal ID: ISSN 1549-7747
Publisher:
IEEE
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; charge amplifier; lab-on-a-chip (LOC); pyroelectric materials; PVDF; CMOS technology

Citation Formats

Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., and Islam, Syed K. A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip. United States: N. p., 2018. Web. doi:10.1109/TCSII.2018.2798929.
Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., & Islam, Syed K. A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip. United States. doi:10.1109/TCSII.2018.2798929.
Wang, Hanfeng, Britton, Charles, Quaiyum, Farhan, Pullano, Salvatore A., Taylor, Logan, Fiorillo, Antonino S., and Islam, Syed K. Fri . "A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip". United States. doi:10.1109/TCSII.2018.2798929. https://www.osti.gov/servlets/purl/1422600.
@article{osti_1422600,
title = {A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip},
author = {Wang, Hanfeng and Britton, Charles and Quaiyum, Farhan and Pullano, Salvatore A. and Taylor, Logan and Fiorillo, Antonino S. and Islam, Syed K.},
abstractNote = {With increasing emphasis on implantable and portable medical devices, low-power, small-chip-area sensor readout system realized in lab-on-a-chip (LOC) platform is gaining more and more importance these days. The main building blocks of the LOC system include a front-end transducer that generates an electrical signal in response to the presence of an analyte of interest, signal processing electronics to process the signal to comply with a specific transmission protocol and a low-power transmitter, all realized in a single integrated circuit platform. Low power consumption and compactness of the components are essential requirements of the LOC system. This paper presents a novel charge sensitive pre-amplifier developed in a standard 180-nm CMOS process suitable for implementing in an LOC platform. The pre-amplifier converts the charge generated by a pyroelectric transducer into a voltage signal, which provides a measurement of the temperature variation in biological fluids. The proposed design is capable of providing 0.8-mV/pC gain while consuming only 2.1 μW of power. Finally, the pre-amplifier composed of integrated components occupies an area of 0.038 mm2.},
doi = {10.1109/TCSII.2018.2798929},
journal = {IEEE Transactions on Circuits and Systems. II, Express Briefs},
number = 8,
volume = 65,
place = {United States},
year = {2018},
month = {1}
}

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Figures / Tables:

Fig. 1 Fig. 1: Schematic diagram of a basic charge amplifier.

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