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Title: Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids

Abstract

Despite recent advances in assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly-designable and dynamic single-walled nanotubes assembled from sequence-defined peptoids through a unique “rolling-up and closure of nanosheet” mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers (APOs) crystallized to form well-defined nanosheets which were then folded to form single-walled peptoid nanotubes (SW-PNTs). These SW-PNTs undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of APOs, we demonstrate the tuning of PNT wall thickness and diameter, and mechanical properties. AFM-based mechanical measurements indicate that PNTs are highly stiff (Young’s Modulus ~13-17 GPa), comparable to the stiffest known biological materials. We further demonstrate that the precise incorporation of functional groups within PNTs and the application of functional PNTs in water decontamination. We believe these SW-PNTs can provide a robust platform for development of biomimetic materials tailored to specific applications.

Authors:
 [1]; ORCiD logo [2];  [1];  [3];  [4];  [1];  [5];  [6];  [6];  [7];  [8];  [1];  [9];  [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  2. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Xiangtan Univ, Hunan (China)
  3. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Washington State Univ., Pullman, WA (United States)
  4. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhejiang Univ., Hangzhou (China).
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); China Univ. of Petroleum, Qingdao (China)
  6. Xiangtan Univ, Hunan (China)
  7. Washington State Univ., Pullman, WA (United States)
  8. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Linyi Univ., Shandong (China)
  9. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); State Univ. of New York (SUNY), Binghamton, NY (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1422277
Report Number(s):
PNNL-SA-126066
Journal ID: ISSN 2041-1723; KC0203030
Grant/Contract Number:  
AC05-76RL01830
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Jin, Haibao, Ding, Yan-Huai, Wang, Mingming, Song, Yang, Liao, Zhihao, Newcomb, Christina J., Wu, Xuepeng, Tang, Xian-Qiong, Li, Zheng, Lin, Yuehe, Yan, Feng, Jian, Tengyue, Mu, Peng, and Chen, Chun-Long. Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids. United States: N. p., 2018. Web. doi:10.1038/s41467-017-02059-1.
Jin, Haibao, Ding, Yan-Huai, Wang, Mingming, Song, Yang, Liao, Zhihao, Newcomb, Christina J., Wu, Xuepeng, Tang, Xian-Qiong, Li, Zheng, Lin, Yuehe, Yan, Feng, Jian, Tengyue, Mu, Peng, & Chen, Chun-Long. Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids. United States. doi:10.1038/s41467-017-02059-1.
Jin, Haibao, Ding, Yan-Huai, Wang, Mingming, Song, Yang, Liao, Zhihao, Newcomb, Christina J., Wu, Xuepeng, Tang, Xian-Qiong, Li, Zheng, Lin, Yuehe, Yan, Feng, Jian, Tengyue, Mu, Peng, and Chen, Chun-Long. Thu . "Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids". United States. doi:10.1038/s41467-017-02059-1. https://www.osti.gov/servlets/purl/1422277.
@article{osti_1422277,
title = {Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids},
author = {Jin, Haibao and Ding, Yan-Huai and Wang, Mingming and Song, Yang and Liao, Zhihao and Newcomb, Christina J. and Wu, Xuepeng and Tang, Xian-Qiong and Li, Zheng and Lin, Yuehe and Yan, Feng and Jian, Tengyue and Mu, Peng and Chen, Chun-Long},
abstractNote = {Despite recent advances in assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly-designable and dynamic single-walled nanotubes assembled from sequence-defined peptoids through a unique “rolling-up and closure of nanosheet” mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers (APOs) crystallized to form well-defined nanosheets which were then folded to form single-walled peptoid nanotubes (SW-PNTs). These SW-PNTs undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of APOs, we demonstrate the tuning of PNT wall thickness and diameter, and mechanical properties. AFM-based mechanical measurements indicate that PNTs are highly stiff (Young’s Modulus ~13-17 GPa), comparable to the stiffest known biological materials. We further demonstrate that the precise incorporation of functional groups within PNTs and the application of functional PNTs in water decontamination. We believe these SW-PNTs can provide a robust platform for development of biomimetic materials tailored to specific applications.},
doi = {10.1038/s41467-017-02059-1},
journal = {Nature Communications},
number = 1,
volume = 9,
place = {United States},
year = {2018},
month = {1}
}

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    Works referencing / citing this record:

    Hierarchical Assembly of Peptoid‐Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution
    journal, July 2019


    Hierarchical Assembly of Peptoid‐Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution
    journal, July 2019