skip to main content


Title: Manipulation of the Geometry and Modulation of the Optical Response of Surfactant-Free Gold Nanostars: A Systematic Bottom-Up Synthesis

Among plasmonic nanoparticles, surfactant-free branched gold nanoparticles have exhibited exceptional properties as a nanoplatform for a wide variety of applications ranging from surface-enhanced Raman scattering sensing and imaging applications to photothermal treatment and photoimmunotherapy for cancer treatments. The effectiveness and reliability of branched gold nanoparticles in biomedical applications strongly rely on the consistency and reproducibility of physical, chemical, optical, and therapeutic properties of nanoparticles, which are mainly governed by their morphological features. Herein, we present an optimized bottom-up synthesis that improves the reproducibility and homogeneity of the gold-branched nanoparticles with desired morphological features and optical properties. We identified that the order of reagent addition is crucial for improved homogeneity of the branched nature of nanoparticles that enable a high batch-to-batch reproducibility and reliability. In addition, a different combination of the synthesis parameters, in particular, additive halides and concentration ratios of reactive Au to Ag and Au to Au seeds, which yield branched nanoparticle of similar localized surface plasmon resonances but with distinguishable changes in the dimensions of the branches, was realized. Overall, our study introduces the design parameters for the purpose-tailored manufacturing of surfactant-free gold nanostars in a reliable manner.
 [1] ;  [2] ;  [1] ; ORCiD logo [3]
  1. Duke Univ., Durham, NC (United States). Dept. of Biomedical Engineering. Fitzpatrick Inst. of Photonics
  2. Duke Univ., Durham, NC (United States). Dept. of Biomedical Engineering
  3. Duke Univ., Durham, NC (United States). Dept. of Biomedical Engineering. Fitzpatrick Inst. of Photonics. Dept. of Chemistry
Publication Date:
Grant/Contract Number:
SC0014077; 1R21CA196426; 1R21AI120981-01
Published Article
Journal Name:
ACS Omega
Additional Journal Information:
Journal Volume: 3; Journal Issue: 2; Journal ID: ISSN 2470-1343
American Chemical Society (ACS)
Research Org:
Duke Univ., Durham, NC (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Inst. of Health (NIH) (United States)
Country of Publication:
United States
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; analytical chemistry; molecular structure; nanoparticles; nanostructures
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1425840