Transcranial direct current stimulation of dorsolateral prefrontal cortex during encoding improves recall but not recognition memory

Leshikar, Eric D.; Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael Christopher Stefan; Sklenar, Allison M.; Frankenstein, Andrea N.; Matzen, Laura E.

doi:10.1016/j.neuropsychologia.2017.10.022

Title: Transcranial direct current stimulation of dorsolateral prefrontal cortex during encoding improves recall but not recognition memory

Journal Article · 19 October 2017 · Neuropsychologia

DOI: https://doi.org/10.1016/j.neuropsychologia.2017.10.022 · OSTI ID:1421859

Leshikar, Eric D. ^[1]; Leach, Ryan C. ^[1]; McCurdy, Matthew P. ^[1]; Trumbo, Michael Christopher Stefan ^[2]; Sklenar, Allison M. ^[1]; Frankenstein, Andrea N. ^[1]; Matzen, Laura E. ^[2]

Univ. of Illinois at Chicago, Chicago, IL (United States)
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Prior work demonstrates that application of transcranial direct current stimulation (tDCS) improves memory. In this study, we investigated tDCS effects on face-name associative memory using both recall and recognition tests. Participants encoded face-name pairs under either active (1.5 mA) or sham (.1 mA) stimulation applied to the scalp adjacent to the left dorsolateral prefrontal cortex (dlPFC), an area known to support associative memory. Participants’ memory was then tested after study (day one) and then again after a 24-h delay (day two), to assess both immediate and delayed stimulation effects on memory. Results indicated that active relative to sham stimulation led to substantially improved recall (more than 50%) at both day one and day two. Recognition memory performance did not differ between stimulation groups at either time point. These results suggest that stimulation at encoding improves memory performance by enhancing memory for details that enable a rich recollective experience, but that these improvements are evident only under some testing conditions, especially those that rely on recollection. Altogether, stimulation of the dlPFC could have led to recall improvement through enhanced encoding from stimulation or from carryover effects of stimulation that influenced retrieval processes, or both.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000; NA0003525

OSTI ID:: 1421859

Alternate ID(s):: OSTI ID: 1549355

Report Number(s):: SAND-2017-13369J; 659419

Journal Information:: Neuropsychologia, Vol. 106, Issue C; ISSN 0028-3932

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Brain stimulation
tDCS
dlPFC
Immediate effects of tDCS
Delayed effects of tDCS
Associative memory
Recall
Recognition
Episodic memory

Title: Transcranial direct current stimulation of dorsolateral prefrontal cortex during encoding improves recall but not recognition memory

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References (66)

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