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Title: Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery

Abstract

A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000–1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.

Authors:
 [1];  [2];  [3];  [3]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [2];  [5]; ORCiD logo [3]
  1. Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, China, Molecular Imaging Program at Stanford (MIPS)
  2. Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023
  3. Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University
  4. CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai
  5. Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, China
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Natural Science Foundation of China (NNSFC)
OSTI Identifier:
1421775
Alternate Identifier(s):
OSTI ID: 1505220
Grant/Contract Number:  
SC0008397; GJHZ1622
Resource Type:
Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Name: Chemical Science Journal Volume: 9 Journal Issue: 12; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES

Citation Formats

Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, and Cheng, Zhen. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery. United Kingdom: N. p., 2018. Web. doi:10.1039/C8SC00206A.
Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, & Cheng, Zhen. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery. United Kingdom. doi:10.1039/C8SC00206A.
Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, and Cheng, Zhen. Mon . "Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery". United Kingdom. doi:10.1039/C8SC00206A.
@article{osti_1421775,
title = {Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery},
author = {Shou, Kangquan and Tang, Yufu and Chen, Hao and Chen, Si and Zhang, Lei and Zhang, Ao and Fan, Quli and Yu, Aixi and Cheng, Zhen},
abstractNote = {A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000–1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.},
doi = {10.1039/C8SC00206A},
journal = {Chemical Science},
number = 12,
volume = 9,
place = {United Kingdom},
year = {2018},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1039/C8SC00206A

Citation Metrics:
Cited by: 21 works
Citation information provided by
Web of Science

Figures / Tables:

Figure 1 Figure 1: Synthetic route to PDFT. Detailed synthesis procedures can be found in the ESI.†

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