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Title: Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture

For over thirty years immortalized lung cells have enabled researchers to elucidate lung-pathogen molecular interactions. However, over the last five years numerous commercial companies are now providing affordable, ready-to-use primary lung cells for use in research laboratories. Despite advances in primary cell culture, studies using immortalized lung cells still dominate the recent scientific literature. In this paper, we highlight recent influenza and anthrax studies using in vitro primary lung tissue models and how these models are providing better predictive outcomes for when extrapolated to in vivo observations.
Authors:
 [1] ;  [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Date:
Report Number(s):
PNNL-SA-129079
Journal ID: ISSN 2078-1547; 45304036B
Grant/Contract Number:
AC05-76RL01830
Type:
Accepted Manuscript
Journal Name:
Challenges
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2078-1547
Publisher:
MDPI
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Contributing Orgs:
Joshua Powell; Timothy Straub
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; anthrax; influenza; lung epithelial; NHBE
OSTI Identifier:
1421339

Powell, Joshua D., and Straub, Timothy M.. Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture. United States: N. p., Web. doi:10.3390/challe9010002.
Powell, Joshua D., & Straub, Timothy M.. Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture. United States. doi:10.3390/challe9010002.
Powell, Joshua D., and Straub, Timothy M.. 2018. "Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture". United States. doi:10.3390/challe9010002. https://www.osti.gov/servlets/purl/1421339.
@article{osti_1421339,
title = {Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture},
author = {Powell, Joshua D. and Straub, Timothy M.},
abstractNote = {For over thirty years immortalized lung cells have enabled researchers to elucidate lung-pathogen molecular interactions. However, over the last five years numerous commercial companies are now providing affordable, ready-to-use primary lung cells for use in research laboratories. Despite advances in primary cell culture, studies using immortalized lung cells still dominate the recent scientific literature. In this paper, we highlight recent influenza and anthrax studies using in vitro primary lung tissue models and how these models are providing better predictive outcomes for when extrapolated to in vivo observations.},
doi = {10.3390/challe9010002},
journal = {Challenges},
number = 1,
volume = 9,
place = {United States},
year = {2018},
month = {1}
}