skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges

Authors:
 [1];  [1];  [1];  [1];  [1]
  1. Department of Physics, University of Wisconsin, Milwaukee, Wisconsin 53211, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1421053
Grant/Contract Number:  
FG02-09ER16114; SC0002164
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Structural Dynamics
Additional Journal Information:
Journal Name: Structural Dynamics Journal Volume: 2 Journal Issue: 4; Journal ID: ISSN 2329-7778
Publisher:
American Institute of Physics
Country of Publication:
United States
Language:
English

Citation Formats

Hosseinizadeh, A., Dashti, A., Schwander, P., Fung, R., and Ourmazd, A. Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges. United States: N. p., 2015. Web. doi:10.1063/1.4919740.
Hosseinizadeh, A., Dashti, A., Schwander, P., Fung, R., & Ourmazd, A. Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges. United States. doi:10.1063/1.4919740.
Hosseinizadeh, A., Dashti, A., Schwander, P., Fung, R., and Ourmazd, A. Wed . "Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges". United States. doi:10.1063/1.4919740.
@article{osti_1421053,
title = {Single-particle structure determination by X-ray free-electron lasers: Possibilities and challenges},
author = {Hosseinizadeh, A. and Dashti, A. and Schwander, P. and Fung, R. and Ourmazd, A.},
abstractNote = {},
doi = {10.1063/1.4919740},
journal = {Structural Dynamics},
number = 4,
volume = 2,
place = {United States},
year = {2015},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1063/1.4919740

Citation Metrics:
Cited by: 8 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses
journal, June 2014

  • Xu, Rui; Jiang, Huaidong; Song, Changyong
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5061

Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison
journal, July 2011

  • Moths, Brian; Ourmazd, Abbas
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 67, Issue 5
  • DOI: 10.1107/S0108767311019611

A Bayesian View on Cryo-EM Structure Determination
journal, January 2012


Crystallography without crystals. I. The common-line method for assembling a three-dimensional diffraction volume from single-particle scattering
journal, February 2008

  • Shneerson, V. L.; Ourmazd, A.; Saldin, D. K.
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 2
  • DOI: 10.1107/S0108767307067621

Three-Dimensional Reconstruction of the Giant Mimivirus Particle with an X-Ray Free-Electron Laser
journal, March 2015


Conformations of macromolecules and their complexes from heterogeneous datasets
journal, July 2014

  • Schwander, P.; Fung, R.; Ourmazd, A.
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, Issue 1647
  • DOI: 10.1098/rstb.2013.0567

High-resolution structure of viruses from random diffraction snapshots
journal, July 2014

  • Hosseinizadeh, A.; Schwander, P.; Dashti, A.
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, Issue 1647
  • DOI: 10.1098/rstb.2013.0326

Solving structure with sparse, randomly-oriented x-ray data
journal, January 2012

  • Philipp, Hugh T.; Ayyer, Kartik; Tate, Mark W.
  • Optics Express, Vol. 20, Issue 12
  • DOI: 10.1364/OE.20.013129

The symmetries of image formation by scattering I Theoretical framework
journal, January 2012

  • Giannakis, Dimitrios; Schwander, Peter; Ourmazd, Abbas
  • Optics Express, Vol. 20, Issue 12
  • DOI: 10.1364/OE.20.012799

Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization
journal, December 2006

  • Scheres, Sjors H. W.; Gao, Haixiao; Valle, Mikel
  • Nature Methods, Vol. 4, Issue 1
  • DOI: 10.1038/nmeth992

Microholography of Living Organisms
journal, October 1982


How Should We Think About the Ribosome?
journal, June 2012


Signal, noise, and resolution in correlated fluctuations from snapshot small-angle x-ray scattering
journal, July 2011


Reconstruction algorithm for single-particle diffraction imaging experiments
journal, August 2009


Optimal mapping of x-ray laser diffraction patterns into three dimensions using routing algorithms
journal, October 2013


The symmetries of image formation by scattering II Applications
journal, January 2012

  • Schwander, Peter; Giannakis, Dimitrios; Yoon, Chun Hong
  • Optics Express, Vol. 20, Issue 12
  • DOI: 10.1364/OE.20.012827

Structure from fleeting illumination of faint spinning objects in flight
journal, November 2008

  • Fung, Russell; Shneerson, Valentin; Saldin, Dilano K.
  • Nature Physics, Vol. 5, Issue 1
  • DOI: 10.1038/nphys1129

Atomic structure of a single large biomolecule from diffraction patterns of random orientations
journal, July 2012


Potential for biomolecular imaging with femtosecond X-ray pulses
journal, August 2000

  • Neutze, Richard; Wouts, Remco; van der Spoel, David
  • Nature, Vol. 406, Issue 6797
  • DOI: 10.1038/35021099

The linac coherent light source single particle imaging road map
journal, July 2015

  • Aquila, A.; Barty, A.; Bostedt, C.
  • Structural Dynamics, Vol. 2, Issue 4
  • DOI: 10.1063/1.4918726

Structure of the Yeast Mitochondrial Large Ribosomal Subunit
journal, March 2014


Structure of isolated biomolecules obtained from ultrashort x-ray pulses: exploiting the symmetry of random orientations
journal, March 2009


Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy
journal, July 2010

  • Fischer, Niels; Konevega, Andrey L.; Wintermeyer, Wolfgang
  • Nature, Vol. 466, Issue 7304
  • DOI: 10.1038/nature09206

Trajectories of the ribosome as a Brownian nanomachine
journal, November 2014

  • Dashti, Ali; Schwander, Peter; Langlois, Robert
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 49
  • DOI: 10.1073/pnas.1419276111