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Title: Exposure assessment of process-related contaminants in food by biomarker monitoring

Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies. This review focuses on the state of the art with respect to the use of biomarkers of exposure for the process contaminants acrylamide, 3-MCPD esters, glycidyl esters, furan and acrolein. From the overview presented, it becomes clear that the field of assessing human exposure to process-related contaminants in food by biomarker monitoring is promising and strongly developing. The current state of the art as well as the existing data gaps and challenges for the future were defined. They include (1) using PBK modelling and duplicate diet studies to establish, preferably in humans, correlations between external exposure and biomarkers; (2) elucidation of the possible endogenous formation of themore » process-related contaminants and the resulting biomarker levels; (3) the influence of inter-individual variations and how to include that in the biomarker-based exposure predictions; (4) the correction for confounding factors; (5) the value of the different biomarkers in relation to exposure scenario’s and risk assessment, and (6) the possibilities of novel methodologies. Here, in spite of these challenges it can be concluded that biomarker-based exposure assessment provides a unique opportunity to more accurately assess consumer exposure to process-related contaminants in food and thus to better inform risk assessment.« less
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8] ;  [9] ;  [10] ;  [11] ;  [12]
  1. Wageningen Univ., Wageningen (The Netherlands)
  2. International Life Sciences Institute, Brussels (Belgium)
  3. Mondelez International, Bremen (Germany)
  4. Abbott Nutrition, Columbus, OH (United States)
  5. KAO Corp., Tochigi (Japan)
  6. Univ. of Wurzburg, Wurzburg (Germany)
  7. PepsiCo Europe, Leicester (United Kingdom)
  8. Nestle Research Center, Lausanne (Switzerland)
  9. Biochemical Institute for Environmental Carcinogens, Grosshansdorf (Germany)
  10. UNC-Chapel Hill, Chapel Hill, NC (United States)
  11. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  12. Univ. of Kaiserslautern, Kaiserslautern (Germany)
Publication Date:
Grant/Contract Number:
AC05-76RL01830
Type:
Accepted Manuscript
Journal Name:
Archives of Toxicology
Additional Journal Information:
Journal Volume: 92; Journal Issue: 1; Journal ID: ISSN 0340-5761
Publisher:
Springer
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Dietary process-related contaminants; Biomarkers; External exposure assessment; Physiologically based kinetic models; Risk assessment
OSTI Identifier:
1420440