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Title: Biogenesis of zinc storage granules in Drosophila melanogaster


Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for use in protein cofactors, signalling, storage or excretion. Here we identify zinc storage granules as the insect's major zinc reservoir in principal Malpighian tubule epithelial cells of Drosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis. Due to lysosome-related organelle defects caused by mutations in the homologous human genes, patients with Hermansky–Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers.

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Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1468689
Grant/Contract Number:  
AC02-76SF00515; P41GM103393
Resource Type:
Published Article
Journal Name:
Journal of Experimental Biology
Additional Journal Information:
Journal Name: Journal of Experimental Biology Journal Volume: 221 Journal Issue: 6; Journal ID: ISSN 0022-0949
The Company of Biologists
Country of Publication:
United Kingdom
59 BASIC BIOLOGICAL SCIENCES; AP-3 complex; Eye color mutants; ICP-OES; Malpighian tubules; Synchrotron; Zincosomes

Citation Formats

Tejeda-Guzmán, Carlos, Rosas-Arellano, Abraham, Kroll, Thomas, Webb, Samuel M., Barajas-Aceves, Martha, Osorio, Beatriz, and Missirlis, Fanis. Biogenesis of zinc storage granules in Drosophila melanogaster. United Kingdom: N. p., 2018. Web. doi:10.1242/jeb.168419.
Tejeda-Guzmán, Carlos, Rosas-Arellano, Abraham, Kroll, Thomas, Webb, Samuel M., Barajas-Aceves, Martha, Osorio, Beatriz, & Missirlis, Fanis. Biogenesis of zinc storage granules in Drosophila melanogaster. United Kingdom. doi:10.1242/jeb.168419.
Tejeda-Guzmán, Carlos, Rosas-Arellano, Abraham, Kroll, Thomas, Webb, Samuel M., Barajas-Aceves, Martha, Osorio, Beatriz, and Missirlis, Fanis. Wed . "Biogenesis of zinc storage granules in Drosophila melanogaster". United Kingdom. doi:10.1242/jeb.168419.
title = {Biogenesis of zinc storage granules in Drosophila melanogaster},
author = {Tejeda-Guzmán, Carlos and Rosas-Arellano, Abraham and Kroll, Thomas and Webb, Samuel M. and Barajas-Aceves, Martha and Osorio, Beatriz and Missirlis, Fanis},
abstractNote = {Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for use in protein cofactors, signalling, storage or excretion. Here we identify zinc storage granules as the insect's major zinc reservoir in principal Malpighian tubule epithelial cells of Drosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis. Due to lysosome-related organelle defects caused by mutations in the homologous human genes, patients with Hermansky–Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers.},
doi = {10.1242/jeb.168419},
journal = {Journal of Experimental Biology},
number = 6,
volume = 221,
place = {United Kingdom},
year = {2018},
month = {1}

Journal Article:
Free Publicly Available Full Text
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DOI: 10.1242/jeb.168419

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