Biogenesis of zinc storage granules in Drosophila melanogaster

Tejeda-Guzmán, Carlos; Rosas-Arellano, Abraham; Kroll, Thomas; Webb, Samuel M.; Barajas-Aceves, Martha; Osorio, Beatriz; Missirlis, Fanis

doi:10.1242/jeb.168419

Title: Biogenesis of zinc storage granules in Drosophila melanogaster

Journal Article · 19 March 2018 · Journal of Experimental Biology

DOI: https://doi.org/10.1242/jeb.168419 · OSTI ID:1418066

Tejeda-Guzmán, Carlos ^[1];

^[1]; Kroll, Thomas ^[2]; Webb, Samuel M. ^[2]; Barajas-Aceves, Martha ^[3]; Osorio, Beatriz ^[1];

^[1]

Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, C.P. 07360, México
Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA
Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, C.P. 07360, México

ABSTRACT Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for use in protein cofactors, signalling, storage or excretion. Here we identify zinc storage granules as the insect's major zinc reservoir in principal Malpighian tubule epithelial cells of Drosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis. Due to lysosome-related organelle defects caused by mutations in the homologous human genes, patients with Hermansky–Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers.

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Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1418066

Journal Information:: Journal of Experimental Biology, Journal Name: Journal of Experimental Biology Journal Issue: 6 Vol. 221; ISSN 0022-0949

Publisher:: The Company of BiologistsCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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