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Title: Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

The first small-molecule based αvβ 3 -targeted NIR-II/PET dual-modal probes via base-catalyzed thiol-addition chemistry were concisely assembled and evaluated.
Authors:
 [1] ;  [1] ;  [1] ;  [2] ;  [2] ;  [1] ;  [1] ;  [3] ;  [3] ;  [4] ;  [4] ;  [5] ;  [5] ;  [1] ;  [2] ; ORCiD logo [1]
  1. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China
  2. Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, USA
  3. Medical College, Tibet University, Lasa, China
  4. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Center for Experimental Basic Medical Education, Wuhan University, Wuhan 430071, China
  5. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China
Publication Date:
Grant/Contract Number:
SC0008397
Type:
Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Name: Chemical Science Journal Volume: 9 Journal Issue: 8; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry (RSC)
Sponsoring Org:
USDOE
Country of Publication:
United Kingdom
Language:
English
OSTI Identifier:
1417921