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Title: Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Thirdhand smoke (THS) is the contamination that persists after secondhand tobacco smoke has been emitted into air. It refers to the tobacco-related gases and particles that become embedded in materials, such as the carpet, walls, furniture, blankets, and toys. THS is not strictly smoke, but chemicals that adhere to surfaces from which they can be released back into the air, undergo chemical transformations and/or accumulate. Currently, the hazards of THS are not as well documented as the hazards of secondhand smoke (SHS). In this paper, we describe the distribution and chemical changes that occur as SHS is transformed into THS, studies of environmental contamination by THS, human exposure studies, toxicology studies using animal models and in vitro systems, possible approaches for avoiding exposure, remediation of THS contamination, and priorities for further research.
Authors:
ORCiD logo [1] ;  [2] ;  [3] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8] ;  [9] ;  [5] ;  [10] ;  [7] ;  [4] ;  [11]
  1. Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Dept. of Psychiatry. Dept. of Medicine
  2. Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Medical Service. Dept. of Medicine. Dept. of Bioengineering and Therapeutic Sciences. Center for Tobacco Control Research and Education
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Indoor Environment Group
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems & Engineering
  5. Univ. of California, Riverside, CA (United States). Dept. of Cell Biology and Neuroscience
  6. San Diego State Univ., CA (United States). Dept. of Psychology
  7. San Diego State Univ., CA (United States). Graduate School of Public Health
  8. Univ. of Southern California, Los Angeles, CA (United States). Dept. of Preventive Medicine. The Keck School of Medicine
  9. Univ. of California, San Francisco, CA (United States). Division of Occupational and Environmental Medicine. School of Medicine
  10. Univ. of Malta, Msida (Malta). Dept. of Geosciences
  11. Univ. of California, Berkeley, CA (United States). The Center for Integrative Research on Childhood Leukemia and the Environment. School of Public Health
Publication Date:
Grant/Contract Number:
AC02-05CH11231; 20PT-0184; 23PT-0013; 19CA-0164; 24RT-0038; 20KT-0051; 19XT-0070; 18FT-0105; 25IP-0023; 22RT-0139; 17RT-0162H; 24RT-0037H; 23DT-0103; 22DT-0002; 22RT-0141H; 19XT-0151H; 19XT-0166; 25ST-0038; 24RT-0039; P30 DA012393; S10 RR026437; CAHHU0028-15
Type:
Accepted Manuscript
Journal Name:
Chemical Research in Toxicology
Additional Journal Information:
Journal Volume: 30; Journal Issue: 1; Journal ID: ISSN 0893-228X
Publisher:
American Chemical Society (ACS)
Research Org:
Univ. of California, San Francisco, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Riverside, CA (United States); San Diego State Univ., CA (United States)
Sponsoring Org:
USDOE; California Tobacco-Related Disease Research Program (TRDRP) (United States); National Inst. on Drug Abuse (NIDA) (United States); National Inst. of Health (NIH) (United States); Dept. of Housing and Urban Development (HUD) (United States)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
OSTI Identifier:
1417595