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Title: Influences of the heme-lysine crosslink in cytochrome P460 over redox catalysis and nitric oxide sensitivity

A vital role has been identified for the heme-lysine cross-link unique to cytochromes P460: preventing enzyme deactivation during catalysis by the obligate nitrification metabolite nitric oxide.
Authors:
 [1] ;  [1] ; ORCiD logo [1]
  1. Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, USA
Publication Date:
Grant/Contract Number:
AC02-76SF00515; SC0013997
Type:
Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Volume: 9; Journal Issue: 2; Related Information: CHORUS Timestamp: 2018-01-03 13:03:32; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry (RSC)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United Kingdom
Language:
English
OSTI Identifier:
1415513