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Title: The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear

Authors:
; ; ; ; ORCiD logo; ; ; ORCiD logo
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1414337
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Biochimica et Biophysica Acta - General Subjects
Additional Journal Information:
Journal Name: Biochimica et Biophysica Acta - General Subjects Journal Volume: 1861 Journal Issue: 1 PA; Journal ID: ISSN 0304-4165
Publisher:
Elsevier
Country of Publication:
Netherlands
Language:
English

Citation Formats

Zhang, Qi, Wang, Zhongduo, Hou, Feng, Harding, Rachel, Huang, Xinyi, Dong, Aiping, Walker, John R., and Tong, Yufeng. The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear. Netherlands: N. p., 2017. Web. doi:10.1016/j.bbagen.2016.10.019.
Zhang, Qi, Wang, Zhongduo, Hou, Feng, Harding, Rachel, Huang, Xinyi, Dong, Aiping, Walker, John R., & Tong, Yufeng. The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear. Netherlands. https://doi.org/10.1016/j.bbagen.2016.10.019
Zhang, Qi, Wang, Zhongduo, Hou, Feng, Harding, Rachel, Huang, Xinyi, Dong, Aiping, Walker, John R., and Tong, Yufeng. Sun . "The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear". Netherlands. https://doi.org/10.1016/j.bbagen.2016.10.019.
@article{osti_1414337,
title = {The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear},
author = {Zhang, Qi and Wang, Zhongduo and Hou, Feng and Harding, Rachel and Huang, Xinyi and Dong, Aiping and Walker, John R. and Tong, Yufeng},
abstractNote = {},
doi = {10.1016/j.bbagen.2016.10.019},
journal = {Biochimica et Biophysica Acta - General Subjects},
number = 1 PA,
volume = 1861,
place = {Netherlands},
year = {Sun Jan 01 00:00:00 EST 2017},
month = {Sun Jan 01 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.bbagen.2016.10.019

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Cited by: 15 works
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Works referenced in this record:

Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways
journal, August 2012

  • Pérez, Moisés; García-Limones, Carmen; Zapico, Inés
  • Journal of Molecular Cell Biology, Vol. 4, Issue 5
  • DOI: 10.1093/jmcb/mjs047

RING domains: master builders of molecular scaffolds?
journal, February 2000


Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways: Figure 1.
journal, November 2009


Refinement of Macromolecular Structures by the Maximum-Likelihood Method
journal, May 1997

  • Murshudov, G. N.; Vagin, A. A.; Dodson, E. J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3
  • DOI: 10.1107/S0907444996012255

Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8)
journal, October 2006

  • Avvakumov, George V.; Walker, John R.; Xue, Sheng
  • Journal of Biological Chemistry, Vol. 281, Issue 49
  • DOI: 10.1074/jbc.M606704200

HDACi – Targets beyond chromatin
journal, August 2009


Structure-Based Design of Covalent Siah Inhibitors
journal, August 2013


GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness: GRAIL maintains CD4 T cell unresponsiveness
journal, November 2010


To ubiquitinate or to deubiquitinate: it all depends on the partners
journal, September 2008

  • Marfany, Gemma; Denuc, Amanda
  • Biochemical Society Transactions, Vol. 36, Issue 5
  • DOI: 10.1042/BST0360833

An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
journal, April 2013

  • Velasco, Kelly; Zhao, Bin; Callegari, Simone
  • Biochemical and Biophysical Research Communications, Vol. 433, Issue 4
  • DOI: 10.1016/j.bbrc.2013.02.094

DUBs at a glance
journal, July 2009


Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
journal, December 2014

  • Ma, Biao; Chen, Yan; Chen, Ling
  • Nature Cell Biology, Vol. 17, Issue 1
  • DOI: 10.1038/ncb3073

A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research
journal, July 2008

  • Nady, Nataliya; Min, Jinrong; Kareta, Michael S.
  • Trends in Biochemical Sciences, Vol. 33, Issue 7
  • DOI: 10.1016/j.tibs.2008.04.014

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
journal, May 2014


TIN2 Stability Is Regulated by the E3 Ligase Siah2
journal, November 2011


Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes
journal, September 2005

  • Frasor, J.; Danes, J. M.; Funk, C. C.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 37
  • DOI: 10.1073/pnas.0502782102

USP 19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1
journal, March 2016


An analysis of protein domain linkers: their classification and role in protein folding
journal, November 2002

  • George, Richard A.; Heringa, Jaap
  • Protein Engineering, Design and Selection, Vol. 15, Issue 11
  • DOI: 10.1093/protein/15.11.871

Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay
journal, December 2006

  • Senisterra, Guillermo A.; Markin, Eugene; Yamazaki, Ken
  • Journal of Biomolecular Screening, Vol. 11, Issue 8
  • DOI: 10.1177/1087057106294699

Siah1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis*
journal, January 2006

  • Xu, Zhiheng; Sproul, Andrew; Wang, Wenyi
  • Journal of Biological Chemistry, Vol. 281, Issue 1
  • DOI: 10.1074/jbc.M509060200

Mechanism for ubiquitylation of the leukemia fusion proteins AML1‐ETO and PML‐RARα
journal, December 2007

  • Krämer, Oliver H.; Müller, Sylvia; Buchwald, Marc
  • The FASEB Journal, Vol. 22, Issue 5
  • DOI: 10.1096/fj.06-8050com

SIAH proteins: critical roles in leukemogenesis
journal, October 2012


Multiple Comparisons of Log-Likelihoods with Applications to Phylogenetic Inference
journal, August 1999


SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells
journal, April 2014


Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia
journal, February 2014

  • Bagnall, James; Leedale, Joseph; Taylor, Sarah E.
  • Journal of Biological Chemistry, Vol. 289, Issue 9
  • DOI: 10.1074/jbc.M113.500405

Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth
journal, November 2008

  • Ahmed, Atique U.; Schmidt, Rebecca L.; Park, Cheol Hong
  • JNCI: Journal of the National Cancer Institute, Vol. 100, Issue 22
  • DOI: 10.1093/jnci/djn365

Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade
journal, January 2015

  • Tristan, Carlos A.; Ramos, Adriana; Shahani, Neelam
  • Journal of Biological Chemistry, Vol. 290, Issue 1
  • DOI: 10.1074/jbc.M114.596205

Stress-induced decrease in TRAF2 stability is mediated by Siah2
journal, November 2002


Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity
journal, September 2014


SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status
journal, December 2015


Overexpression of Siah2 Is Associated With Poor Prognosis in Patients With Epithelial Ovarian Carcinoma
journal, January 2016


The SPOT-synthesis technique
journal, September 2002


Regulators and Effectors of Siah Ubiquitin Ligases
journal, May 2013

  • Qi, Jianfei; Kim, Hyungsoo; Scortegagna, Marzia
  • Cell Biochemistry and Biophysics, Vol. 67, Issue 1
  • DOI: 10.1007/s12013-013-9636-2

SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation
journal, December 2012


Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses
journal, February 2007

  • Young, Travis W.; Mei, Fang C.; Rosen, Daniel G.
  • Molecular & Cellular Proteomics, Vol. 6, Issue 2
  • DOI: 10.1074/mcp.M600305-MCP200

Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH1
journal, August 2011

  • Cho, Hyun-Soo; Kelly, John D.; Hayami, Shinya
  • Neoplasia, Vol. 13, Issue 8
  • DOI: 10.1593/neo.11512

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis
journal, December 2009


Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy
journal, February 2012


Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
journal, June 2008

  • Winter, Melanie; Sombroek, Dirk; Dauth, Ilka
  • Nature Cell Biology, Vol. 10, Issue 7
  • DOI: 10.1038/ncb1743

SWISS-MODEL: an automated protein homology-modeling server
journal, July 2003


Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer
journal, July 2008

  • Jansen, Maurice P. H. M.; Ruigrok-Ritstier, Kirsten; Dorssers, Lambert C. J.
  • Breast Cancer Research and Treatment, Vol. 116, Issue 2
  • DOI: 10.1007/s10549-008-0125-z

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling
journal, November 2010

  • Liang, Jian; Saad, Yasser; Lei, Tianhua
  • Journal of Experimental Medicine, Vol. 207, Issue 13
  • DOI: 10.1084/jem.20092641

The Ubiquitin Ligase Siah2 and the Hypoxia Response
journal, April 2009


Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
journal, February 2014


Structural classification of zinc fingers: SURVEY AND SUMMARY
journal, January 2003


USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains*
journal, August 2011

  • Scortegagna, Marzia; Subtil, Tony; Qi, Jianfei
  • Journal of Biological Chemistry, Vol. 286, Issue 31
  • DOI: 10.1074/jbc.M111.218214

The molecular programme of tumour reversion: the steps beyond malignant transformation
journal, January 2009

  • Telerman, Adam; Amson, Robert
  • Nature Reviews Cancer, Vol. 9, Issue 3
  • DOI: 10.1038/nrc2589

Homology modeling and in silico screening of inhibitors for the substrate binding domain of human Siah2: implications for hypoxia-induced cancers
journal, March 2011

  • Anupriya, Gopalsamy; Roopa, Kothapalli; Basappa, S.
  • Journal of Molecular Modeling, Vol. 17, Issue 12
  • DOI: 10.1007/s00894-011-1025-4

HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes
journal, July 2006

  • Minor, Wladek; Cymborowski, Marcin; Otwinowski, Zbyszek
  • Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 8
  • DOI: 10.1107/S0907444906019949

Seven in Absentia Homolog 2 (Siah2) Protein Is a Regulator of NF-E2-related Factor 2 (Nrf2)*
journal, June 2013

  • Baba, Kazunobu; Morimoto, Haruka; Imaoka, Susumu
  • Journal of Biological Chemistry, Vol. 288, Issue 25
  • DOI: 10.1074/jbc.M112.438762

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Modulation of multidrug resistance in cancer cells by the E3 ubiquitin ligase seven-in-absentia homologue 1
journal, December 2007

  • Liu, M.; Aneja, R.; Wang, H.
  • The Journal of Pathology, Vol. 214, Issue 4
  • DOI: 10.1002/path.2312

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

RAPIDO: a web server for the alignment of protein structures in the presence of conformational changes
journal, May 2008

  • Mosca, R.; Schneider, T. R.
  • Nucleic Acids Research, Vol. 36, Issue Web Server
  • DOI: 10.1093/nar/gkn197

The Siah2-HIF-FoxA2 axis in prostate cancer - new markers and therapeutic opportunities
journal, September 2010


CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2
journal, January 2016

  • García-Limones, C.; Lara-Chica, M.; Jiménez-Jiménez, C.
  • Oncogene, Vol. 35, Issue 33
  • DOI: 10.1038/onc.2015.495

Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
journal, October 2005

  • Santelli, Eugenio; Leone, Marilisa; Li, Chenlong
  • Journal of Biological Chemistry, Vol. 280, Issue 40
  • DOI: 10.1074/jbc.M506707200

Siah: New Players in the Cellular Response to Hypoxia
journal, November 2004


Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications
journal, January 2005


The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers
journal, August 2015

  • Knauer, Shirley K.; Mahendrarajah, Nisintha; Roos, Wynand P.
  • Cytokine & Growth Factor Reviews, Vol. 26, Issue 4
  • DOI: 10.1016/j.cytogfr.2015.04.002

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
journal, August 2011

  • Lipkowitz, Stanley; Weissman, Allan M.
  • Nature Reviews Cancer, Vol. 11, Issue 9
  • DOI: 10.1038/nrc3120

Two high-resolution structures of the human E3 ubiquitin ligase Siah1
journal, November 2013

  • Rimsa, Vadim; Eadsforth, Thomas C.; Hunter, William N.
  • Acta Crystallographica Section F Structural Biology and Crystallization Communications, Vol. 69, Issue 12
  • DOI: 10.1107/S1744309113031448

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
journal, November 2013

  • Hasson, Samuel A.; Kane, Lesley A.; Yamano, Koji
  • Nature, Vol. 504, Issue 7479
  • DOI: 10.1038/nature12748

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia*
journal, January 2012

  • Altun, Mikael; Zhao, Bin; Velasco, Kelly
  • Journal of Biological Chemistry, Vol. 287, Issue 3
  • DOI: 10.1074/jbc.M111.305615

Role of Quinones in Toxicology
journal, March 2000

  • Bolton, Judy L.; Trush, Michael A.; Penning, Trevor M.
  • Chemical Research in Toxicology, Vol. 13, Issue 3
  • DOI: 10.1021/tx9902082

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation
journal, May 2010

  • Buchwald, M.; Pietschmann, K.; Müller, J. P.
  • Leukemia, Vol. 24, Issue 8
  • DOI: 10.1038/leu.2010.114

Regulation of Synaptophysin Degradation by Mammalian Homologues of Seven in Absentia
journal, March 2002

  • Wheeler, Tiffany C.; Chin, Lih-Shen; Li, Yankun
  • Journal of Biological Chemistry, Vol. 277, Issue 12
  • DOI: 10.1074/jbc.M107857200

Molecular recognition of p53 and MDM2 by USP7/HAUSP
journal, February 2006

  • Sheng, Yi; Saridakis, Vivian; Sarkari, Feroz
  • Nature Structural & Molecular Biology, Vol. 13, Issue 3
  • DOI: 10.1038/nsmb1067

Defining the Human Deubiquitinating Enzyme Interaction Landscape
journal, July 2009


MUSCLE: multiple sequence alignment with high accuracy and high throughput
journal, March 2004

  • Edgar, R. C.
  • Nucleic Acids Research, Vol. 32, Issue 5, p. 1792-1797
  • DOI: 10.1093/nar/gkh340

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins
journal, October 2015

  • Zhang, Qi; Fan, Lixin; Hou, Feng
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep15660

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling
journal, December 2001

  • Polekhina, Galina; House, Colin M.; Traficante, Nadia
  • Nature Structural Biology, Vol. 9, Issue 1
  • DOI: 10.1038/nsb743

Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.
journal, April 1996

  • Amson, R. B.; Nemani, M.; Roperch, J. P.
  • Proceedings of the National Academy of Sciences, Vol. 93, Issue 9
  • DOI: 10.1073/pnas.93.9.3953

UniProt: a hub for protein information
journal, October 2014

  • Consortium, UniPot
  • Nucleic Acids Research, Vol. 43, Issue D1, p. D204-D212
  • DOI: 10.1093/nar/gku989

Siah: A Promising Anticancer Target
journal, March 2013


NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation
journal, January 2014


RING Domain E3 Ubiquitin Ligases
journal, June 2009


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206