The Role of Extracellular Fluid in Biokinetic Modeling
Abstract
Here, the pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements. In any biokinetic model, the fastest transfer rates are not determinable with the usual datasets, and if determined empirically, these rates will have very large and highly correlated uncertainties, so particular values of these rates, even though the model fits the available data, are not significant. A pharmacokinetic front-end provides values for these fast rates. An example of such a front-end for a 200–g rat is given.
- Authors:
-
- Santa Fe, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Melohill Technology, LLC, Rockville, MD (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1414152
- Report Number(s):
- LA-UR-17-23147
Journal ID: ISSN 0017-9078; TRN: US1800674
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Health Physics
- Additional Journal Information:
- Journal Volume: 113; Journal Issue: 6; Journal ID: ISSN 0017-9078
- Publisher:
- Health Physics Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 61 RADIATION PROTECTION AND DOSIMETRY; Radiation Protection
Citation Formats
Miller, Guthrie, Klumpp, John A., Melo, Dunstana, and Poudel, Deepesh. The Role of Extracellular Fluid in Biokinetic Modeling. United States: N. p., 2017.
Web. doi:10.1097/HP.0000000000000722.
Miller, Guthrie, Klumpp, John A., Melo, Dunstana, & Poudel, Deepesh. The Role of Extracellular Fluid in Biokinetic Modeling. United States. https://doi.org/10.1097/HP.0000000000000722
Miller, Guthrie, Klumpp, John A., Melo, Dunstana, and Poudel, Deepesh. Fri .
"The Role of Extracellular Fluid in Biokinetic Modeling". United States. https://doi.org/10.1097/HP.0000000000000722. https://www.osti.gov/servlets/purl/1414152.
@article{osti_1414152,
title = {The Role of Extracellular Fluid in Biokinetic Modeling},
author = {Miller, Guthrie and Klumpp, John A. and Melo, Dunstana and Poudel, Deepesh},
abstractNote = {Here, the pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements. In any biokinetic model, the fastest transfer rates are not determinable with the usual datasets, and if determined empirically, these rates will have very large and highly correlated uncertainties, so particular values of these rates, even though the model fits the available data, are not significant. A pharmacokinetic front-end provides values for these fast rates. An example of such a front-end for a 200–g rat is given.},
doi = {10.1097/HP.0000000000000722},
journal = {Health Physics},
number = 6,
volume = 113,
place = {United States},
year = {2017},
month = {12}
}
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