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Title: The Role of Extracellular Fluid in Biokinetic Modeling

Abstract

Here, the pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements. In any biokinetic model, the fastest transfer rates are not determinable with the usual datasets, and if determined empirically, these rates will have very large and highly correlated uncertainties, so particular values of these rates, even though the model fits the available data, are not significant. A pharmacokinetic front-end provides values for these fast rates. An example of such a front-end for a 200–g rat is given.

Authors:
 [1];  [2];  [3];  [2]
  1. Santa Fe, NM (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Melohill Technology, LLC, Rockville, MD (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1414152
Report Number(s):
LA-UR-17-23147
Journal ID: ISSN 0017-9078; TRN: US1800674
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Accepted Manuscript
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 113; Journal Issue: 6; Journal ID: ISSN 0017-9078
Publisher:
Health Physics Society
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; Radiation Protection

Citation Formats

Miller, Guthrie, Klumpp, John A., Melo, Dunstana, and Poudel, Deepesh. The Role of Extracellular Fluid in Biokinetic Modeling. United States: N. p., 2017. Web. doi:10.1097/HP.0000000000000722.
Miller, Guthrie, Klumpp, John A., Melo, Dunstana, & Poudel, Deepesh. The Role of Extracellular Fluid in Biokinetic Modeling. United States. doi:10.1097/HP.0000000000000722.
Miller, Guthrie, Klumpp, John A., Melo, Dunstana, and Poudel, Deepesh. Fri . "The Role of Extracellular Fluid in Biokinetic Modeling". United States. doi:10.1097/HP.0000000000000722. https://www.osti.gov/servlets/purl/1414152.
@article{osti_1414152,
title = {The Role of Extracellular Fluid in Biokinetic Modeling},
author = {Miller, Guthrie and Klumpp, John A. and Melo, Dunstana and Poudel, Deepesh},
abstractNote = {Here, the pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements. In any biokinetic model, the fastest transfer rates are not determinable with the usual datasets, and if determined empirically, these rates will have very large and highly correlated uncertainties, so particular values of these rates, even though the model fits the available data, are not significant. A pharmacokinetic front-end provides values for these fast rates. An example of such a front-end for a 200–g rat is given.},
doi = {10.1097/HP.0000000000000722},
journal = {Health Physics},
number = 6,
volume = 113,
place = {United States},
year = {2017},
month = {12}
}

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