Methylpyrrole inhibitors of BET bromodomains
- Authors:
- more »
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1414004
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Bioorganic and Medicinal Chemistry Letters
- Additional Journal Information:
- Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Volume: 27 Journal Issue: 10; Journal ID: ISSN 0960-894X
- Publisher:
- Elsevier
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., and McDaniel, Keith F. Methylpyrrole inhibitors of BET bromodomains. United Kingdom: N. p., 2017.
Web. doi:10.1016/j.bmcl.2017.02.057.
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., & McDaniel, Keith F. Methylpyrrole inhibitors of BET bromodomains. United Kingdom. https://doi.org/10.1016/j.bmcl.2017.02.057
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., and McDaniel, Keith F. Mon .
"Methylpyrrole inhibitors of BET bromodomains". United Kingdom. https://doi.org/10.1016/j.bmcl.2017.02.057.
@article{osti_1414004,
title = {Methylpyrrole inhibitors of BET bromodomains},
author = {Hasvold, Lisa A. and Sheppard, George S. and Wang, Le and Fidanze, Steven D. and Liu, Dachun and Pratt, John K. and Mantei, Robert A. and Wada, Carol K. and Hubbard, Robbert and Shen, Yu and Lin, Xiaoyu and Huang, Xiaoli and Warder, Scott E. and Wilcox, Denise and Li, Leiming and Buchanan, F. Greg and Smithee, Lauren and Albert, Daniel H. and Magoc, Terrance J. and Park, Chang H. and Petros, Andrew M. and Panchal, Sanjay C. and Sun, Chaohong and Kovar, Peter and Soni, Nirupama B. and Elmore, Steven W. and Kati, Warren M. and McDaniel, Keith F.},
abstractNote = {},
doi = {10.1016/j.bmcl.2017.02.057},
journal = {Bioorganic and Medicinal Chemistry Letters},
number = 10,
volume = 27,
place = {United Kingdom},
year = {Mon May 01 00:00:00 EDT 2017},
month = {Mon May 01 00:00:00 EDT 2017}
}
Free Publicly Available Full Text
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https://doi.org/10.1016/j.bmcl.2017.02.057
https://doi.org/10.1016/j.bmcl.2017.02.057
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Cited by: 17 works
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Works referenced in this record:
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
journal, March 2012
- Filippakopoulos, Panagis; Picaud, Sarah; Mangos, Maria
- Cell, Vol. 149, Issue 1
Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery
journal, March 2015
- Fu, Lei-lei; Tian, Mao; Li, Xiang
- Oncotarget, Vol. 6, Issue 8
Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors
journal, April 2015
- Romero, F. Anthony; Taylor, Alexander M.; Crawford, Terry D.
- Journal of Medicinal Chemistry, Vol. 59, Issue 4
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
journal, June 2014
- Shi, Junwei; Vakoc, Christopher R.
- Molecular Cell, Vol. 54, Issue 5
Clinical progress and pharmacology of small molecule bromodomain inhibitors
journal, August 2016
- Theodoulou, Natalie H.; Tomkinson, Nicholas CO; Prinjha, Rab K.
- Current Opinion in Chemical Biology, Vol. 33
The bromodomain interaction module
journal, May 2012
- Filippakopoulos, Panagis; Knapp, Stefan
- FEBS Letters, Vol. 586, Issue 17
4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading
journal, November 2013
- Lucas, Xavier; Wohlwend, Daniel; Hügle, Martin
- Angewandte Chemie International Edition, Vol. 52, Issue 52
Palladium-catalysed direct arylations of NH-free pyrrole and N-tosylpyrrole with aryl bromides
journal, February 2012
- Bheeter, Charles Beromeo; Bera, Jitendra K.; Doucet, Henri
- Tetrahedron Letters, Vol. 53, Issue 5
Discovering High-Affinity Ligands for Proteins: SAR by NMR
journal, November 1996
- Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.
- Science, Vol. 274, Issue 5292, p. 1531-1534
Ligand efficiency indices as guideposts for drug discovery
journal, April 2005
- Abadzapatero, C.; Metz, J.
- Drug Discovery Today, Vol. 10, Issue 7
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression
journal, February 2010
- Smith, Jennifer A.; White, Elizabeth A.; Sowa, Mathew E.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 8
Structure and ligand of a histone acetyltransferase bromodomain
journal, June 1999
- Dhalluin, Christophe; Carlson, Justin E.; Zeng, Lei
- Nature, Vol. 399, Issue 6735
Structure and acetyl-lysine recognition of the bromodomain
journal, August 2007
- Mujtaba, S.; Zeng, L.; Zhou, M-M
- Oncogene, Vol. 26, Issue 37
Targeting bromodomains: epigenetic readers of lysine acetylation
journal, April 2014
- Filippakopoulos, Panagis; Knapp, Stefan
- Nature Reviews Drug Discovery, Vol. 13, Issue 5
The chemistry of pyrrolic compounds. XXXVII. Monobenzoporphyrins: The rhodoporphyrin of petroleum deposits
journal, January 1977
- Clezy, Ps; Fookes, Cjr; Mirza, Ah
- Australian Journal of Chemistry, Vol. 30, Issue 6
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
journal, July 2003
- Dey, A.; Chitsaz, F.; Abbasi, A.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 15
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening
journal, September 2016
- Navratilova, Iva; Aristotelous, Tonia; Picaud, Sarah
- ACS Medicinal Chemistry Letters, Vol. 7, Issue 12
Suppression of inflammation by a synthetic histone mimic
journal, November 2010
- Nicodeme, Edwige; Jeffrey, Kate L.; Schaefer, Uwe
- Nature, Vol. 468, Issue 7327