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Title: Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

A direct aliphatic C–H 18 F labeling method using [ 18 F]fluoride ion at inaccessible and unreactive sites is reported.
Authors:
 [1] ;  [1] ;  [2] ;  [3] ;  [4] ;  [2] ; ORCiD logo [1]
  1. Department of Chemistry, Princeton University, USA
  2. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA, Division of Nuclear Medicine and Molecular Imaging
  3. Department of Process Chemistry, Merck Research Laboratories, Rahway, USA
  4. Imaging Research, Merck Research Laboratories, USA
Publication Date:
Grant/Contract Number:
DE SC0001298
Type:
Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Name: Chemical Science Journal Volume: 9 Journal Issue: 5; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry (RSC)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United Kingdom
Language:
English
OSTI Identifier:
1413343

Liu, Wei, Huang, Xiongyi, Placzek, Michael S., Krska, Shane W., McQuade, Paul, Hooker, Jacob M., and Groves, John T.. Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin. United Kingdom: N. p., Web. doi:10.1039/C7SC04545J.
Liu, Wei, Huang, Xiongyi, Placzek, Michael S., Krska, Shane W., McQuade, Paul, Hooker, Jacob M., & Groves, John T.. Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin. United Kingdom. doi:10.1039/C7SC04545J.
Liu, Wei, Huang, Xiongyi, Placzek, Michael S., Krska, Shane W., McQuade, Paul, Hooker, Jacob M., and Groves, John T.. 2018. "Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin". United Kingdom. doi:10.1039/C7SC04545J.
@article{osti_1413343,
title = {Site-selective 18 F fluorination of unactivated C–H bonds mediated by a manganese porphyrin},
author = {Liu, Wei and Huang, Xiongyi and Placzek, Michael S. and Krska, Shane W. and McQuade, Paul and Hooker, Jacob M. and Groves, John T.},
abstractNote = {A direct aliphatic C–H 18 F labeling method using [ 18 F]fluoride ion at inaccessible and unreactive sites is reported.},
doi = {10.1039/C7SC04545J},
journal = {Chemical Science},
number = 5,
volume = 9,
place = {United Kingdom},
year = {2018},
month = {1}
}