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Title: The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia

Multiple factors help shape the infant intestinal microbiota early in life. Environmental conditions such as the presence of bioactive molecules from breast milk dictate gut microbial growth and survival. Infants also receive distinct, personalized, bacterial exposures leading to differential colonization. Microbial exposures and gut environmental conditions differ between infants in different locations, as does the typical microbial community structure in an infant’s gut. Here we evaluate potential influences on the infant gut microbiota through a longitudinal study on cohorts of breast-fed infants from the neighboring countries of Armenia and Georgia, an area of the world for which the infant microbiome has not been previously investigated. Marker gene sequencing of 16S ribosomal genes revealed that the gut microbial communities of infants from these countries were dominated by bifidobacteria, were different from each other, and were marginally influenced by their mother’s secretor status. Species-level differences in the bifidobacterial communities of each country and birth method were also observed. These community differences suggest that environmental variation between individuals in different locations may influence the gut microbiota of infants.
Authors:
 [1] ;  [2] ;  [3] ;  [2] ;  [2] ;  [3] ;  [2] ;  [2] ;  [4] ;  [4] ;  [2] ;  [5] ;  [6] ;  [1]
  1. Univ. of California, Davis, CA (United States). Dept. of Food Science and Technology. Foods for Health Inst. Dept. of Viticulture and Enology
  2. National Center for Disease Control and Public Health of Georgia, Tbilisi (Georgia)
  3. International Association for Human and Animals Health Improvement (IAHAHI), Yerevan (Armenia)
  4. Armenian National Agrarian Univ., Yerevan (Armenia)
  5. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division
  6. Univ. of California, Davis, CA (United States). Genome Center
Publication Date:
Grant/Contract Number:
AC02-05CH11231; R01AT007079; R01AT008759; P509; A-1957
Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 7; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Research Org:
Univ. of California, Davis, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); National Center for Disease Control and Public Health of Georgia, Tbilisi (Georgia); Armenian National Agrarian Univ., Yerevan (Armenia)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation (NA-20); National Inst. of Health (NIH) (United States); Science and Technology Center in Ukraine (STCU); International Science and Technology Center (ISTC)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 54 ENVIRONMENTAL SCIENCES; microbial ecology; policy and public health in microbiology
OSTI Identifier:
1411652

Lewis, Zachery T., Sidamonidze, Ketevan, Tsaturyan, Vardan, Tsereteli, David, Khachidze, Nika, Pepoyan, Astghik, Zhgenti, Ekaterine, Tevzadze, Liana, Manvelyan, Anahit, Balayan, Marine, Imnadze, Paata, Torok, Tamas, Lemay, Danielle G., and Mills, David A.. The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia. United States: N. p., Web. doi:10.1038/srep40932.
Lewis, Zachery T., Sidamonidze, Ketevan, Tsaturyan, Vardan, Tsereteli, David, Khachidze, Nika, Pepoyan, Astghik, Zhgenti, Ekaterine, Tevzadze, Liana, Manvelyan, Anahit, Balayan, Marine, Imnadze, Paata, Torok, Tamas, Lemay, Danielle G., & Mills, David A.. The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia. United States. doi:10.1038/srep40932.
Lewis, Zachery T., Sidamonidze, Ketevan, Tsaturyan, Vardan, Tsereteli, David, Khachidze, Nika, Pepoyan, Astghik, Zhgenti, Ekaterine, Tevzadze, Liana, Manvelyan, Anahit, Balayan, Marine, Imnadze, Paata, Torok, Tamas, Lemay, Danielle G., and Mills, David A.. 2017. "The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia". United States. doi:10.1038/srep40932. https://www.osti.gov/servlets/purl/1411652.
@article{osti_1411652,
title = {The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia},
author = {Lewis, Zachery T. and Sidamonidze, Ketevan and Tsaturyan, Vardan and Tsereteli, David and Khachidze, Nika and Pepoyan, Astghik and Zhgenti, Ekaterine and Tevzadze, Liana and Manvelyan, Anahit and Balayan, Marine and Imnadze, Paata and Torok, Tamas and Lemay, Danielle G. and Mills, David A.},
abstractNote = {Multiple factors help shape the infant intestinal microbiota early in life. Environmental conditions such as the presence of bioactive molecules from breast milk dictate gut microbial growth and survival. Infants also receive distinct, personalized, bacterial exposures leading to differential colonization. Microbial exposures and gut environmental conditions differ between infants in different locations, as does the typical microbial community structure in an infant’s gut. Here we evaluate potential influences on the infant gut microbiota through a longitudinal study on cohorts of breast-fed infants from the neighboring countries of Armenia and Georgia, an area of the world for which the infant microbiome has not been previously investigated. Marker gene sequencing of 16S ribosomal genes revealed that the gut microbial communities of infants from these countries were dominated by bifidobacteria, were different from each other, and were marginally influenced by their mother’s secretor status. Species-level differences in the bifidobacterial communities of each country and birth method were also observed. These community differences suggest that environmental variation between individuals in different locations may influence the gut microbiota of infants.},
doi = {10.1038/srep40932},
journal = {Scientific Reports},
number = ,
volume = 7,
place = {United States},
year = {2017},
month = {2}
}

Works referenced in this record:

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Search and clustering orders of magnitude faster than BLAST
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