The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome
Abstract
Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. Here in this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1414300
- Alternate Identifier(s):
- OSTI ID: 1411555
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Published Article
- Journal Name:
- Cell
- Additional Journal Information:
- Journal Name: Cell Journal Volume: 167 Journal Issue: 5; Journal ID: ISSN 0092-8674
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Spurrell, Cailyn H., Dickel, Diane E., and Visel, Axel. The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome. United States: N. p., 2016.
Web. doi:10.1016/j.cell.2016.10.054.
Spurrell, Cailyn H., Dickel, Diane E., & Visel, Axel. The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome. United States. https://doi.org/10.1016/j.cell.2016.10.054
Spurrell, Cailyn H., Dickel, Diane E., and Visel, Axel. Tue .
"The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome". United States. https://doi.org/10.1016/j.cell.2016.10.054.
@article{osti_1414300,
title = {The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome},
author = {Spurrell, Cailyn H. and Dickel, Diane E. and Visel, Axel},
abstractNote = {Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. Here in this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.},
doi = {10.1016/j.cell.2016.10.054},
journal = {Cell},
number = 5,
volume = 167,
place = {United States},
year = {Tue Nov 01 00:00:00 EDT 2016},
month = {Tue Nov 01 00:00:00 EDT 2016}
}
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https://doi.org/10.1016/j.cell.2016.10.054
https://doi.org/10.1016/j.cell.2016.10.054
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Cited by: 18 works
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