Carboxysomes: metabolic modules for CO2 fixation
Abstract
The carboxysome is a bacterial microcompartment encapsulating the enzymes carbonic anhydrase and ribulose-1,5-bisphosphate carboxylase/oxygenase. As the site of CO2 fixation, it serves an essential role in the carbon dioxide concentrating mechanism of many chemoautotrophs and all cyanobacteria. Carboxysomes and other bacterial microcompartments self-assemble through specific protein–protein interactions that are typically mediated by conserved protein domains. In this review, we frame our current understanding of carboxysomes in the context of their component protein domains with their inherent function as the ‘building blocks’ of carboxysomes. These building blocks are organized in genetic modules (conserved chromosomal loci) that encode for carboxysomes and ancillary proteins essential for the integration of the organelle with the rest of cellular metabolism. This conceptual framework provides the foundation for ‘plug-and-play’ engineering of carboxysomes as CO2 fixation modules in a variety of biotechnological applications.
- Authors:
-
- Michigan State Univ., East Lansing, MI (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Michigan State Univ., East Lansing, MI (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Berkeley Synthetic Biology Inst., CA (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Colorado School of Mines, Golden, CO (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1409782
- Alternate Identifier(s):
- OSTI ID: 1843736
- Report Number(s):
- LA-UR-17-25514
Journal ID: ISSN 1574-6968
- Grant/Contract Number:
- AC52-06NA25396; FG02-91ER20021; E0007089; EE0007089
- Resource Type:
- Accepted Manuscript
- Journal Name:
- FEMS Microbiology Letters (Online)
- Additional Journal Information:
- Journal Name: FEMS Microbiology Letters (Online); Journal Volume: 364; Journal Issue: 18; Journal ID: ISSN 1574-6968
- Publisher:
- Federation of European Microbiological Societies
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; cyanobacteria; carbon fixation; carboxysome; modularity; protein domains; synthetic biology; 09 BIOMASS FUELS
Citation Formats
Turmo, Aiko, Gonzalez-Esquer, Cesar Raul, and Kerfeld, Cheryl A. Carboxysomes: metabolic modules for CO2 fixation. United States: N. p., 2017.
Web. doi:10.1093/femsle/fnx176.
Turmo, Aiko, Gonzalez-Esquer, Cesar Raul, & Kerfeld, Cheryl A. Carboxysomes: metabolic modules for CO2 fixation. United States. https://doi.org/10.1093/femsle/fnx176
Turmo, Aiko, Gonzalez-Esquer, Cesar Raul, and Kerfeld, Cheryl A. Mon .
"Carboxysomes: metabolic modules for CO2 fixation". United States. https://doi.org/10.1093/femsle/fnx176. https://www.osti.gov/servlets/purl/1409782.
@article{osti_1409782,
title = {Carboxysomes: metabolic modules for CO2 fixation},
author = {Turmo, Aiko and Gonzalez-Esquer, Cesar Raul and Kerfeld, Cheryl A.},
abstractNote = {The carboxysome is a bacterial microcompartment encapsulating the enzymes carbonic anhydrase and ribulose-1,5-bisphosphate carboxylase/oxygenase. As the site of CO2 fixation, it serves an essential role in the carbon dioxide concentrating mechanism of many chemoautotrophs and all cyanobacteria. Carboxysomes and other bacterial microcompartments self-assemble through specific protein–protein interactions that are typically mediated by conserved protein domains. In this review, we frame our current understanding of carboxysomes in the context of their component protein domains with their inherent function as the ‘building blocks’ of carboxysomes. These building blocks are organized in genetic modules (conserved chromosomal loci) that encode for carboxysomes and ancillary proteins essential for the integration of the organelle with the rest of cellular metabolism. This conceptual framework provides the foundation for ‘plug-and-play’ engineering of carboxysomes as CO2 fixation modules in a variety of biotechnological applications.},
doi = {10.1093/femsle/fnx176},
journal = {FEMS Microbiology Letters (Online)},
number = 18,
volume = 364,
place = {United States},
year = {2017},
month = {8}
}
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