Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix
Abstract
Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.
- Authors:
-
[1]
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP); LANL Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1409773
- Alternate Identifier(s):
- OSTI ID: 1435228; OSTI ID: 1562756
- Report Number(s):
- LA-UR-17-23917
Journal ID: ISSN 0003-2670
- Grant/Contract Number:
- AC52-06NA25396; AC05-00OR22725; LDRD 20160439ER
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Analytica Chimica Acta
- Additional Journal Information:
- Journal Volume: 998; Journal ID: ISSN 0003-2670
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 111Ag; CL resin; theranostic; thorium target; proton irradiation; nuclear reaction cross sections
Citation Formats
Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix. United States: N. p., 2017.
Web. doi:10.1016/j.aca.2017.10.020.
Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., & Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix. United States. https://doi.org/10.1016/j.aca.2017.10.020
Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Mon .
"Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix". United States. https://doi.org/10.1016/j.aca.2017.10.020. https://www.osti.gov/servlets/purl/1409773.
@article{osti_1409773,
title = {Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix},
author = {Mastren, Tara and Radchenko, Valery and Engle, Jonathan W. and Weidner, John W. and Owens, Allison and Wyant, Lance E. and Copping, Roy and Brugh, Mark and Nortier, F. Meiring and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael E.},
abstractNote = {Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.},
doi = {10.1016/j.aca.2017.10.020},
journal = {Analytica Chimica Acta},
number = ,
volume = 998,
place = {United States},
year = {Mon Oct 30 00:00:00 EDT 2017},
month = {Mon Oct 30 00:00:00 EDT 2017}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 13 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Table 1:: Measured excitation functions for the 232Th(p,f)111Ag and 232Th(p,f)110mAg reactions
All figures and tables
(5 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Preparation and evaluation of a new radiopharmaceutical for radiosynovectomy, 111Ag-labelled hydroxyapatite (HA) particles
journal, March 2008
- Chattopadhyay, Sankha; Vimalnath, K. V.; Saha, Sujata
- Applied Radiation and Isotopes, Vol. 66, Issue 3
The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials
journal, January 2013
- Aweda, Tolulope A.; Ikotun, Oluwatayo; Mastren, Tara
- MedChemComm, Vol. 4, Issue 6
Radionuclide production for therapeutic radiopharmaceuticals
journal, November 2002
- Neves, M.; Kling, A.; Lambrecht, R. M.
- Applied Radiation and Isotopes, Vol. 57, Issue 5
Theranostics: Combining Imaging and Therapy
journal, October 2011
- Kelkar, Sneha S.; Reineke, Theresa M.
- Bioconjugate Chemistry, Vol. 22, Issue 10
Therapeutic Radiopharmaceuticals
journal, September 1999
- Volkert, Wynn A.; Hoffman, Timothy J.
- Chemical Reviews, Vol. 99, Issue 9
Radiometals for Combined Imaging and Therapy
journal, October 2012
- Cutler, Cathy S.; Hennkens, Heather M.; Sisay, Nebiat
- Chemical Reviews, Vol. 113, Issue 2, p. 858-883
Radioimmunotherapy of Cancer Using Monoclonal Antibodies to Target Radiotherapy
journal, September 2000
- Illidge, Timothy; Brock, Susannah
- Current Pharmaceutical Design, Vol. 6, Issue 14
Linkage of silver to antibodies through 2-imino thiolane
journal, June 1995
- Hazra, D. K.; Stevenson, G. T.; Kan, K. S.
- Cell Biophysics, Vol. 26, Issue 3
An improved method for the separation of 111Ag from irradiated natural palladium
journal, July 1992
- Alberto, R.; Bläuenstein, P.; Novak-Hofer, I.
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 7
Separation of 111Ag from neutron irradiated natural palladium using alumina as an adsorbent
journal, January 2000
- Khalid, M.; Mushtaq, A.; Iqbal, M. Z.
- Applied Radiation and Isotopes, Vol. 52, Issue 1
Experimental cross sections for charged particle production of the therapeutic radionuclide 111Ag and its PET imaging analogue 104m,gAg
journal, April 2004
- Hermanne, A.; Takács, S.; Tárkányi, F.
- Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 217, Issue 2
The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: A clinical phase II study
journal, July 2001
- Waldherr, C.; Pless, M.; Maecke, H.
- Annals of Oncology, Vol. 12, Issue 7, p. 941-945
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes
journal, February 2015
- Radchenko, V.; Engle, J. W.; Wilson, J. J.
- Journal of Chromatography A, Vol. 1380, p. 55-63
Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides
journal, December 2017
- Radchenko, Valery; Mastren, Tara; Meyer, Catherine A. L.
- Talanta, Vol. 175
Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets
journal, December 2016
- Griswold, J. R.; Medvedev, D. G.; Engle, J. W.
- Applied Radiation and Isotopes, Vol. 118
Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
journal, January 2016
- Radchenko, Valery; Engle, Jonathan W.; Wilson, Justin J.
- Radiochimica Acta, Vol. 104, Issue 5
Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix
journal, August 2017
- Mastren, Tara; Radchenko, Valery; Owens, Allison
- Scientific Reports, Vol. 7, Issue 1
Characterization of an extraction chromatographic resin for the separation and determination of 36Cl and 129I
journal, August 2010
- Zulauf, Alexander; Happel, Steffen; Mokili, Marcel Bandombele
- Journal of Radioanalytical and Nuclear Chemistry, Vol. 286, Issue 2
Determination of silver in soils, sediments, and rocks by organic-chelate extraction and atomic absorption spectrophotometry
journal, March 1971
- Chao, T. T.; Ball, J. W.; Nakagawa, H. M.
- Analytica Chimica Acta, Vol. 54, Issue 1
Selective precipitation of silver halides from homogeneous solution. Separation of iodide, bromide, and chloride using volatilization of ammonia
journal, December 1960
- Firsching, F. H.
- Analytical Chemistry, Vol. 32, Issue 13
One-pot microwave synthesis of tertiary phosphine sulfides directly from aromatic alkenes, elemental phosphorus and sulfur in KOH–DMSO system
journal, June 2013
- Kuimov, Vladimir A.; Malysheva, Svetlana F.; Gusarova, Nina K.
- Journal of Sulfur Chemistry, Vol. 35, Issue 2
Tri-n-octylphosphine sulfide:
journal, January 1965
- Elliott, Donald E.; Banks, Charlesa V.
- Analytica Chimica Acta, Vol. 33
Liquid-solid extraction of gold(III) from aqueous chloride solutions by macroporous resins impregnated with triisobutyl phosphine sulfide (Cyanex 471)
journal, April 1992
- Villaescusa, I.; Salvadó, V.; de Pablo, J.
- Reactive Polymers, Vol. 17, Issue 1
Recovery and enrichment of heavy metals using new hybrid Donnan dialysis systems combining cation exchange textile and solvent impregnated resin
journal, June 2013
- Berdous, Dalila; Akretche, Djamal-Eddine
- Korean Journal of Chemical Engineering, Vol. 30, Issue 7
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV
journal, November 2012
- Weidner, J. W.; Mashnik, S. G.; John, K. D.
- Applied Radiation and Isotopes, Vol. 70, Issue 11
Production of 52Fe via proton-induced reactions on manganese and nickel
journal, January 1990
- Steyn, G. F.; Mills, S. J.; Nortier, F. M.
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 3
225Ac and 223Ra production via 800MeV proton irradiation of natural thorium targets
journal, November 2012
- Weidner, J. W.; Mashnik, S. G.; John, K. D.
- Applied Radiation and Isotopes, Vol. 70, Issue 11
Selenium-72 formation via natBr(p,x) induced by 100MeV Protons: Steps towards a novel 72Se/72As generator system
journal, April 2012
- Ballard, B.; Wycoff, D.; Birnbaum, E. R.
- Applied Radiation and Isotopes, Vol. 70, Issue 4
Some Studies of the Products of the High-Energy Fission Process
journal, June 1954
- Lindner, M.; Osborne, R. N.
- Physical Review, Vol. 94, Issue 5
Proton-induced fission at 190 MeV of and
journal, February 1999
- Duijvestijn, M. C.; Koning, A. J.; Beijers, J. P. M.
- Physical Review C, Vol. 59, Issue 2
Cross sections from proton irradiation of thorium at 800 MeV
journal, July 2013
- Engle, Jonathan W.; Mashnik, Stepan G.; Weidner, John W.
- Physical Review C, Vol. 88, Issue 1
Ac, La, and Ce radioimpurities in 225Ac produced in 40–200 MeV proton irradiations of thorium
journal, January 2014
- Engle, Jonathan W.; Weidner, John W.; Ballard, Beau D.
- Radiochimica Acta, Vol. 102, Issue 7
Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry
journal, May 2010
- Pourmand, Ali; Dauphas, Nicolas
- Talanta, Vol. 81, Issue 3
Works referencing / citing this record:
Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium
journal, March 2019
- Fitzsimmons, Jonathan; Griswold, Justin; Medvedev, Dmitri
- Molecules, Vol. 24, Issue 6
Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf
journal, March 2018
- Huang, Yaoyao; Hu, Yang; Chen, Lvcun
- PLOS ONE, Vol. 13, Issue 3
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.