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Title: Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Abstract

Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [2];  [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP); LANL Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1409773
Alternate Identifier(s):
OSTI ID: 1435228; OSTI ID: 1562756
Report Number(s):
LA-UR-17-23917
Journal ID: ISSN 0003-2670
Grant/Contract Number:  
AC52-06NA25396; AC05-00OR22725; LDRD 20160439ER
Resource Type:
Accepted Manuscript
Journal Name:
Analytica Chimica Acta
Additional Journal Information:
Journal Volume: 998; Journal ID: ISSN 0003-2670
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 111Ag; CL resin; theranostic; thorium target; proton irradiation; nuclear reaction cross sections

Citation Formats

Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix. United States: N. p., 2017. Web. doi:10.1016/j.aca.2017.10.020.
Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., & Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix. United States. https://doi.org/10.1016/j.aca.2017.10.020
Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Mon . "Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix". United States. https://doi.org/10.1016/j.aca.2017.10.020. https://www.osti.gov/servlets/purl/1409773.
@article{osti_1409773,
title = {Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix},
author = {Mastren, Tara and Radchenko, Valery and Engle, Jonathan W. and Weidner, John W. and Owens, Allison and Wyant, Lance E. and Copping, Roy and Brugh, Mark and Nortier, F. Meiring and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael E.},
abstractNote = {Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. Herein we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.},
doi = {10.1016/j.aca.2017.10.020},
journal = {Analytica Chimica Acta},
number = ,
volume = 998,
place = {United States},
year = {2017},
month = {10}
}

Journal Article:

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Cited by: 4 works
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Figures / Tables:

Table 1: Table 1:: Measured excitation functions for the 232Th(p,f)111Ag and 232Th(p,f)110mAg reactions

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Works referencing / citing this record:

Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium
journal, March 2019


Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf
journal, March 2018


Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.