Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

doi:10.1016/j.aca.2017.10.020

Title: Chromatographic separation of the theranostic radionuclide ¹¹¹Ag from a proton irradiated thorium matrix

Abstract

Column chromatographic methods have been developed to separate no-carrier-added ¹¹¹Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing ²²⁵Ac separation design. In this paper, we report the separation of ¹¹¹Ag both prior and subsequent to ²²⁵Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R ₃P = S) and alkyl phosphine oxides (R ₃P = O). The recovery yield of ¹¹¹Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) ²²⁵Ac recovery. Both processes were successfully performed with insignificant impacts on ²²⁵Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Finally and additionally, measured cross sections for the production of ¹¹¹Ag and ^110mAg for the ²³²Th(p,f) ^110m,111Ag reactions are reported within.

Authors:

Mastren, Tara ^[1]; Radchenko, Valery ^[1]; Engle, Jonathan W. ^[1]; Weidner, John W. ^[1]; Owens, Allison ^[2]; Wyant, Lance E. ^[2]; Copping, Roy ^[2]; Brugh, Mark ^[1]; Nortier, F. Meiring ^[1]; Birnbaum, Eva R. ^[1]; John, Kevin D. ^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division

Publication Date:: 2017-10-30

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26); LANL Laboratory Directed Research and Development (LDRD) Program

OSTI Identifier:: 1409773

Alternate Identifier(s):: OSTI ID: 1435228; OSTI ID: 1562756

Report Number(s):: [LA-UR-17-23917]
[Journal ID: ISSN 0003-2670]

Grant/Contract Number:: [AC52-06NA25396; AC05-00OR22725; LDRD 20160439ER]

Resource Type:: Accepted Manuscript

Journal Name:: Analytica Chimica Acta

Additional Journal Information:: [ Journal Volume: 998]; Journal ID: ISSN 0003-2670

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 111Ag; CL resin; theranostic; thorium target; proton irradiation; nuclear reaction cross sections

Citation Formats


                    Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix.  United States: N. p., 2017. 
        Web.  doi:10.1016/j.aca.2017.10.020.

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                    Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., & Fassbender, Michael E. Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix.  United States.  doi:10.1016/j.aca.2017.10.020.

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                    Mastren, Tara, Radchenko, Valery, Engle, Jonathan W., Weidner, John W., Owens, Allison, Wyant, Lance E., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., and Fassbender, Michael E. Mon .  
        "Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix".  United States.  doi:10.1016/j.aca.2017.10.020.  https://www.osti.gov/servlets/purl/1409773.

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@article{osti_1409773,

  title        = {Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix},

  author       = {Mastren, Tara and Radchenko, Valery and Engle, Jonathan W. and Weidner, John W. and Owens, Allison and Wyant, Lance E. and Copping, Roy and Brugh, Mark and Nortier, F. Meiring and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael E.},

  abstractNote = {Column chromatographic methods have been developed to separate no-carrier-added 111Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing 225Ac separation design. In this paper, we report the separation of 111Ag both prior and subsequent to 225Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of 111Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) 225Ac recovery. Both processes were successfully performed with insignificant impacts on 225Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Finally and additionally, measured cross sections for the production of 111Ag and 110mAg for the 232Th(p,f)110m,111Ag reactions are reported within.},

  doi          = {10.1016/j.aca.2017.10.020},

  journal      = {Analytica Chimica Acta},

  number       = ,

  volume       = [998],

  place        = {United States},

  year         = {2017},

  month        = {10}

}

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DOI: 10.1016/j.aca.2017.10.020

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Figures / Tables:

Table 1:: Measured excitation functions for the ²³²Th(p,f)¹¹¹Ag and ²³²Th(p,f)^110mAg reactions

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Title: Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Abstract

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Figures / Tables:

Title: Chromatographic separation of the theranostic radionuclide ¹¹¹Ag from a proton irradiated thorium matrix