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Title: Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models

The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [4] ;  [1] ;  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Nanjing Medical Univ. (China). Drum Tower Clinical Medical School. Dept. of Gastroenterology
  3. Monogram Biosciences Inc., South San Francisco, CA (United States)
  4. Nanjing Medical Univ. (China). State Key Lab. of Reproductive Medicine. Inst. of Toxicology
Publication Date:
Grant/Contract Number:
AC02-05CH11231; 19XT-0070; 20PT-0184H; 24RT-0038
Type:
Accepted Manuscript
Journal Name:
International Journal of Molecular Sciences (Online)
Additional Journal Information:
Journal Name: International Journal of Molecular Sciences (Online); Journal Volume: 18; Journal Issue: 5; Journal ID: ISSN 1422-0067
Publisher:
MDPI
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE; Univ. of California Tobacco-Related Disease Research Program (TRDRP)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; thirdhand smoke; secondhand smoke; DNA damage; DNA strand breaks; DNA adducts; genotoxicity; early exposure; animal studies; health impact; tobacco control
OSTI Identifier:
1408431