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Title: An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe

Abstract

Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized 129Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of 129Xe gas. This device was limited by 129Xe polarizations less than 1%, 129Xe NMR signals smaller than 20 nT, and transport of hyperpolarized 129Xe over millimeter lengths. Higher polarizations, versatile detection schemes, and flow of 129Xe over larger distances are desirable for wider applications. Here we demonstrate an ultra-sensitive microfabricated platform that achieves 129Xe polarizations reaching 7%, NMR signals exceeding 1 μT, lifetimes up to 6 s, and simultaneous two-mode detection, consisting of a high-sensitivity in situ channel with signal-to-noise of 105 and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of conditions. 129Xe is hyperpolarized and detected in locations more than 1 cm apart. Our versatile device is an optimal platform for microfluidic magnetic resonance in particular, but equally attractive for wider nuclear spin applications benefitting from ultra-sensitive detection, long coherences, and simple instrumentation.

Authors:
 [1];  [1];  [2];  [1];  [3];  [4];  [4];  [4];  [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Science Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
  2. National Inst. of Standards and Technology (NIST), Boulder, CO (United States). Time and Frequency Division; Univ. of Colorado, Boulder, CO (United States). Dept. of Physics
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Science Division
  4. National Inst. of Standards and Technology (NIST), Boulder, CO (United States). Time and Frequency Division
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1408421
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 7; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; imaging and sensing; microfluidics; NMR spectroscopy; optical sensors

Citation Formats

Kennedy, Daniel J., Seltzer, Scott J., Jiménez-Martínez, Ricardo, Ring, Hattie L., Malecek, Nicolas S., Knappe, Svenja, Donley, Elizabeth A., Kitching, John, Bajaj, Vikram S., and Pines, Alexander. An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe. United States: N. p., 2017. Web. doi:10.1038/srep43994.
Kennedy, Daniel J., Seltzer, Scott J., Jiménez-Martínez, Ricardo, Ring, Hattie L., Malecek, Nicolas S., Knappe, Svenja, Donley, Elizabeth A., Kitching, John, Bajaj, Vikram S., & Pines, Alexander. An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe. United States. doi:https://doi.org/10.1038/srep43994
Kennedy, Daniel J., Seltzer, Scott J., Jiménez-Martínez, Ricardo, Ring, Hattie L., Malecek, Nicolas S., Knappe, Svenja, Donley, Elizabeth A., Kitching, John, Bajaj, Vikram S., and Pines, Alexander. Tue . "An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe". United States. doi:https://doi.org/10.1038/srep43994. https://www.osti.gov/servlets/purl/1408421.
@article{osti_1408421,
title = {An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe},
author = {Kennedy, Daniel J. and Seltzer, Scott J. and Jiménez-Martínez, Ricardo and Ring, Hattie L. and Malecek, Nicolas S. and Knappe, Svenja and Donley, Elizabeth A. and Kitching, John and Bajaj, Vikram S. and Pines, Alexander},
abstractNote = {Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized 129Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of 129Xe gas. This device was limited by 129Xe polarizations less than 1%, 129Xe NMR signals smaller than 20 nT, and transport of hyperpolarized 129Xe over millimeter lengths. Higher polarizations, versatile detection schemes, and flow of 129Xe over larger distances are desirable for wider applications. Here we demonstrate an ultra-sensitive microfabricated platform that achieves 129Xe polarizations reaching 7%, NMR signals exceeding 1 μT, lifetimes up to 6 s, and simultaneous two-mode detection, consisting of a high-sensitivity in situ channel with signal-to-noise of 105 and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of conditions. 129Xe is hyperpolarized and detected in locations more than 1 cm apart. Our versatile device is an optimal platform for microfluidic magnetic resonance in particular, but equally attractive for wider nuclear spin applications benefitting from ultra-sensitive detection, long coherences, and simple instrumentation.},
doi = {10.1038/srep43994},
journal = {Scientific Reports},
number = ,
volume = 7,
place = {United States},
year = {2017},
month = {3}
}

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    Works referencing / citing this record:

    Chip-scale atomic devices
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