On the structure and mechanism of two‐pore channels
- Authors:
-
[1];
- Department of Biochemistry and Biophysics University of California San Francisco CA USA
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1401326
- Grant/Contract Number:
- DE‐AC02‐05CH11231; DE‐AC02‐76SF00515
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Federation of European Biochemical Societies (FEBS) Journal
- Additional Journal Information:
- Journal Name: Federation of European Biochemical Societies (FEBS) Journal Journal Volume: 285 Journal Issue: 2; Journal ID: ISSN 1742-464X
- Publisher:
- Wiley-Blackwell
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Kintzer, Alexander F., and Stroud, Robert M. On the structure and mechanism of two‐pore channels. United Kingdom: N. p., 2017.
Web. doi:10.1111/febs.14154.
Kintzer, Alexander F., & Stroud, Robert M. On the structure and mechanism of two‐pore channels. United Kingdom. doi:10.1111/febs.14154.
Kintzer, Alexander F., and Stroud, Robert M. Tue .
"On the structure and mechanism of two‐pore channels". United Kingdom. doi:10.1111/febs.14154.
@article{osti_1401326,
title = {On the structure and mechanism of two‐pore channels},
author = {Kintzer, Alexander F. and Stroud, Robert M.},
abstractNote = {},
doi = {10.1111/febs.14154},
journal = {Federation of European Biochemical Societies (FEBS) Journal},
number = 2,
volume = 285,
place = {United Kingdom},
year = {2017},
month = {7}
}
Free Publicly Available Full Text
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DOI: 10.1111/febs.14154
DOI: 10.1111/febs.14154
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Works referenced in this record:
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
journal, April 2010
- Sancak, Yasemin; Bar-Peled, Liron; Zoncu, Roberto
- Cell, Vol. 141, Issue 2
The human two-pore channel 1 is modulated by cytosolic and luminal calcium
journal, March 2017
- Lagostena, Laura; Festa, Margherita; Pusch, Michael
- Scientific Reports, Vol. 7, Issue 1
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells
journal, January 2017
- Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.
- Cancer Research, Vol. 77, Issue 6
Lysosomal Acidification Mechanisms
journal, March 2012
- Mindell, Joseph A.
- Annual Review of Physiology, Vol. 74, Issue 1
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells
journal, March 1999
- Cancela, Jose Manuel; Churchill, Grant C.; Galione, Antony
- Nature, Vol. 398, Issue 6722
Redox-dependent modulation of the carrot SV channel by cytosolic pH
journal, October 2004
- Scholz-Starke, Joachim; Angeli, Alexis De; Ferraretto, Cristiana
- FEBS Letters, Vol. 576, Issue 3
A melanosomal two-pore sodium channel regulates pigmentation
journal, May 2016
- Bellono, Nicholas W.; Escobar, Iliana E.; Oancea, Elena
- Scientific Reports, Vol. 6, Issue 1
An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells: Targeting of Two-Pore Channels to the Tonoplast
journal, May 2012
- Larisch, Nina; Schulze, Christina; Galione, Antony
- Traffic, Vol. 13, Issue 7
Molecular Determinants of High Affinity Phenylalkylamine Block of l-type Calcium Channels in Transmembrane Segment IIIS6 and the Pore Region of the α 1 Subunit
journal, July 1997
- Hockerman, Gregory H.; Johnson, Barry D.; Abbott, Michael R.
- Journal of Biological Chemistry, Vol. 272, Issue 30
mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State
journal, February 2013
- Cang, Chunlei; Zhou, Yandong; Navarro, Betsy
- Cell, Vol. 152, Issue 4
Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis
journal, December 2014
- Horton, Jaime S.; Wakano, Clay T.; Speck, Mark
- Channels, Vol. 9, Issue 1
Modulation of plant TPC channels by polyunsaturated fatty acids
journal, October 2012
- Gutla, Paul Vijay Kanth; Boccaccio, Anna; De Angeli, Alexis
- Journal of Experimental Botany, Vol. 63, Issue 17
Identification of a chemical probe for NAADP by virtual screening
journal, February 2009
- Naylor, Edmund; Arredouani, Abdelilah; Vasudevan, Sridhar R.
- Nature Chemical Biology, Vol. 5, Issue 4
Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases
journal, February 2014
- Jha, A.; Ahuja, M.; Patel, S.
- The EMBO Journal, Vol. 33, Issue 5
The Lysosome as a Regulatory Hub
journal, October 2016
- Perera, Rushika M.; Zoncu, Roberto
- Annual Review of Cell and Developmental Biology, Vol. 32, Issue 1
Cytoplasmic calcium regulates voltage-dependent ion channels in plant vacuoles
journal, October 1987
- Hedrich, R.; Neher, E.
- Nature, Vol. 329, Issue 6142
The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
journal, June 2009
- Zong, Xiangang; Schieder, Michael; Cuny, Hartmut
- Pflügers Archiv - European Journal of Physiology, Vol. 458, Issue 5
The fou2 Gain-of-Function Allele and the Wild-Type Allele of Two Pore Channel 1 Contribute to Different Extents or by Different Mechanisms to Defense Gene Expression in Arabidopsis
journal, December 2007
- Bonaventure, Gustavo; Gfeller, Aurélie; Rodríguez, Víctor M.
- Plant and Cell Physiology, Vol. 48, Issue 12
Lysosomal Physiology
journal, February 2015
- Xu, Haoxing; Ren, Dejian
- Annual Review of Physiology, Vol. 77, Issue 1
Aluminum as a specific inhibitor of plant TPC1 Ca2+ channels
journal, November 2004
- Kawano, Tomonori; Kadono, Takashi; Fumoto, Katsumi
- Biochemical and Biophysical Research Communications, Vol. 324, Issue 1
The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
journal, May 2016
- Garrity, Abigail G.; Wang, Wuyang; Collier, Crystal MD
- eLife, Vol. 5
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
journal, January 2015
- Rebsamen, Manuele; Pochini, Lorena; Stasyk, Taras
- Nature, Vol. 519, Issue 7544
Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution
journal, August 2016
- Wu, Jianping; Yan, Zhen; Li, Zhangqiang
- Nature, Vol. 537, Issue 7619
mTOR Signaling in Growth Control and Disease
journal, April 2012
- Laplante, Mathieu; Sabatini, David M.
- Cell, Vol. 149, Issue 2
A Gating Charge Transfer Center in Voltage Sensors
journal, April 2010
- Tao, X.; Lee, A.; Limapichat, W.
- Science, Vol. 328, Issue 5974
Function and dysfunction of two-pore channels
journal, July 2015
- Patel, Sandip
- Science Signaling, Vol. 8, Issue 384
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
journal, October 2011
- Gómez-Suaga, Patricia; Luzón-Toro, Berta; Churamani, Dev
- Human Molecular Genetics, Vol. 21, Issue 3
Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg
journal, November 2011
- Walseth, Timothy F.; Lin-Moshier, Yaping; Jain, Pooja
- Journal of Biological Chemistry, Vol. 287, Issue 4
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
journal, June 2016
- Zhang, Xiaoli; Cheng, Xiping; Yu, Lu
- Nature Communications, Vol. 7, Issue 1
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
journal, December 2015
- Guo, Jiangtao; Zeng, Weizhong; Chen, Qingfeng
- Nature, Vol. 531, Issue 7593
The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix
journal, January 2016
- Larisch, Nina; Kirsch, Sonja A.; Schambony, Alexandra
- Cellular and Molecular Life Sciences, Vol. 73, Issue 13
Crystal structure of the epithelial calcium channel TRPV6
journal, June 2016
- Saotome, Kei; Singh, Appu K.; Yelshanskaya, Maria V.
- Nature, Vol. 534, Issue 7608
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
journal, March 2017
- Castellano, Brian M.; Thelen, Ashley M.; Moldavski, Ofer
- Science, Vol. 355, Issue 6331
TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
journal, October 2012
- Wang, Xiang; Zhang, Xiaoli; Dong, Xian-ping
- Cell, Vol. 151, Issue 2
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
journal, April 1998
- Doyle, D. A.
- Science, Vol. 280, Issue 5360
Progressive Depolarization: A Unified Hypothesis for Defibrillation and Fibrillation Induction by Shocks
journal, May 1998
- Dillon, Stephen M.; Kwaku, Kevin F.
- Journal of Cardiovascular Electrophysiology, Vol. 9, Issue 5
Calcium channels in higher plants
journal, May 2000
- White, Philip J.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1465, Issue 1-2
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
journal, January 2015
- Wang, S.; Tsun, Z. -Y.; Wolfson, R. L.
- Science, Vol. 347, Issue 6218
NAADP mobilizes calcium from acidic organelles through two-pore channels
journal, April 2009
- Calcraft, Peter J.; Ruas, Margarida; Pan, Zui
- Nature, Vol. 459, Issue 7246
A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability
journal, September 2014
- Cang, Chunlei; Aranda, Kimberly; Ren, Dejian
- Nature Communications, Vol. 5, Issue 1
TPC2 Is a Novel NAADP-sensitive Ca 2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca 2+
journal, August 2010
- Pitt, Samantha J.; Funnell, Tim M.; Sitsapesan, Mano
- Journal of Biological Chemistry, Vol. 285, Issue 45
Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
journal, December 2010
- Hooper, Robert; Churamani, Dev; Brailoiu, Eugen
- Journal of Biological Chemistry, Vol. 286, Issue 11
Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae
journal, October 2009
- Zhang, Lijin; Geng, Yanling; Duan, Wenjuan
- Journal of Separation Science, Vol. 32, Issue 20
Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca 2+ release and Ca 2+ influx
journal, August 2016
- Kilpatrick, Bethan S.; Yates, Elizabeth; Grimm, Christian
- Journal of Cell Science, Vol. 129, Issue 20
Tuning the ion selectivity of two-pore channels
journal, January 2017
- Guo, Jiangtao; Zeng, Weizhong; Jiang, Youxing
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 5
Aging: Central role for autophagy and the lysosomal degradative system
journal, July 2009
- Rajawat, Yogendra S.; Hilioti, Zoe; Bossis, Ioannis
- Ageing Research Reviews, Vol. 8, Issue 3
The fou2 mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium
journal, June 2009
- Beyhl, Diana; Hörtensteiner, Stefan; Martinoia, Enrico
- The Plant Journal, Vol. 58, Issue 5
The crystal structure of a voltage-gated sodium channel
journal, July 2011
- Payandeh, Jian; Scheuer, Todd; Zheng, Ning
- Nature, Vol. 475, Issue 7356
Functions of Lysosomes
journal, March 1966
- de Duve, Christian; Wattiaux, Robert
- Annual Review of Physiology, Vol. 28, Issue 1
Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana
journal, March 2016
- Kintzer, Alexander F.; Stroud, Robert M.
- Nature, Vol. 531, Issue 7593
A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells
journal, July 2015
- Galione, Antony
- Cell Calcium, Vol. 58, Issue 1
Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels
journal, November 2014
- Rahman, T.; Cai, X.; Brailoiu, G. C.
- Science Signaling, Vol. 7, Issue 352
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel
journal, November 2013
- Tang, Lin; Gamal El-Din, Tamer M.; Payandeh, Jian
- Nature, Vol. 505, Issue 7481
TPC: the NAADP discovery channel?
journal, June 2015
- Morgan, Anthony J.; Davis, Lianne C.; Ruas, Margarida
- Biochemical Society Transactions, Vol. 43, Issue 3
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
journal, March 2016
- Li, Xinran; Rydzewski, Nicholas; Hider, Ahmad
- Nature Cell Biology, Vol. 18, Issue 4
Expression of Ca 2+ ‐permeable two‐pore channels rescues NAADP signalling in TPC ‐deficient cells
journal, April 2015
- Ruas, Margarida; Davis, Lianne C.; Chen, Cheng‐Chang
- The EMBO Journal, Vol. 34, Issue 13
A gain-of-function allele of TPC1 activates oxylipin biogenesis after leaf wounding in Arabidopsis: A cation channel regulates oxylipin biogenesis
journal, February 2007
- Bonaventure, Gustavo; Gfeller, Aurélie; Proebsting, William M.
- The Plant Journal, Vol. 49, Issue 5
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
journal, May 2012
- Zhang, Xu; Ren, Wenlin; DeCaen, Paul
- Nature, Vol. 486, Issue 7401
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
journal, November 2007
- Long, Stephen B.; Tao, Xiao; Campbell, Ernest B.
- Nature, Vol. 450, Issue 7168
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
journal, December 2015
- Ahuja, S.; Mukund, S.; Deng, L.
- Science, Vol. 350, Issue 6267
A Novel Calcium Binding Site in the Slow Vacuolar Cation Channel TPC1 Senses Luminal Calcium Levels
journal, July 2011
- Dadacz-Narloch, Beata; Beyhl, Diana; Larisch, Christina
- The Plant Cell, Vol. 23, Issue 7
Molecular Determinants of High Affinity Dihydropyridine Binding in L-type Calcium Channels
journal, March 1996
- Peterson, Blaise Z.; Tanada, Timothy N.; Catterall, William A.
- Journal of Biological Chemistry, Vol. 271, Issue 10
Two newly identified genetic determinants of pigmentation in Europeans
journal, May 2008
- Sulem, Patrick; Gudbjartsson, Daniel F.; Stacey, Simon N.
- Nature Genetics, Vol. 40, Issue 7
Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca 2+ -sensitive Organellar Two-pore Channel TPC1
journal, April 2012
- Rybalchenko, Volodymyr; Ahuja, Malini; Coblentz, Jessica
- Journal of Biological Chemistry, Vol. 287, Issue 24
Reversible protein phosphorylation regulates the activity of the slow-vacuolar ion channel
journal, June 1997
- Bethke, Paul C.; Jones, Russell L.
- The Plant Journal, Vol. 11, Issue 6
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation
journal, August 2014
- Lin-Moshier, Y.; Keebler, M. V.; Hooper, R.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 36
Hax-1 identified as a two-pore channel (TPC)-binding protein
journal, November 2013
- Lam, Andy K. M.; Galione, Antony; Lai, F. Anthony
- FEBS Letters, Vol. 587, Issue 23
Organelle-specific Subunit Interactions of the Vertebrate Two-pore Channel Family
journal, December 2014
- Ogunbayo, Oluseye A.; Zhu, Yingmin; Shen, Bing
- Journal of Biological Chemistry, Vol. 290, Issue 2
Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+
journal, May 2014
- Pitt, S. J.; Lam, A. K. M.; Rietdorf, K.
- Science Signaling, Vol. 7, Issue 326
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
journal, July 2009
- Brailoiu, Eugen; Churamani, Dev; Cai, Xinjiang
- The Journal of Cell Biology, Vol. 186, Issue 2
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
journal, March 2014
- Grabiner, B. C.; Nardi, V.; Birsoy, K.
- Cancer Discovery, Vol. 4, Issue 5
The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP
journal, June 2013
- Churamani, Dev; Hooper, Robert; Rahman, Taufiq
- Biochemical Journal, Vol. 453, Issue 1
Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells
journal, November 2011
- Lin-Moshier, Yaping; Walseth, Timothy F.; Churamani, Dev
- Journal of Biological Chemistry, Vol. 287, Issue 4
Redox agents regulate ion channel activity in vacuoles from higher plant cells
journal, January 1999
- Carpaneto, Armando; Cantù, Alberto M.; Gambale, Franco
- FEBS Letters, Vol. 442, Issue 2-3
Pleiotropic and Sex-Specific Effects of Cancer GWAS SNPs on Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study
journal, March 2015
- Kocarnik, Jonathan M.; Park, S. Lani; Han, Jiali
- PLOS ONE, Vol. 10, Issue 3
Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution
journal, February 2017
- Shen, Huaizong; Zhou, Qiang; Pan, Xiaojing
- Science, Vol. 355, Issue 6328
TPC2 controls pigmentation by regulating melanosome pH and size
journal, May 2016
- Ambrosio, Andrea L.; Boyle, Judith A.; Aradi, Al E.
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 20
The voltage-gated sodium channel TPC1 confers endolysosomal excitability
journal, April 2014
- Cang, Chunlei; Bekele, Biruk; Ren, Dejian
- Nature Chemical Biology, Vol. 10, Issue 6
Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs
journal, August 2016
- Tang, Lin; Gamal El-Din, Tamer M.; Swanson, Teresa M.
- Nature, Vol. 537, Issue 7618
Differential contribution of EF-hands to the Ca2+-dependent activation in the plant two-pore channel TPC1: Molecular mechanism of Ca2+ dependence in TPC1
journal, August 2011
- Schulze, Christina; Sticht, Heinrich; Meyerhoff, Petra
- The Plant Journal, Vol. 68, Issue 3
Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking
journal, April 2010
- Ruas, Margarida; Rietdorf, Katja; Arredouani, Abdelilah
- Current Biology, Vol. 20, Issue 8
Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain
journal, July 2016
- Jaślan, D.; Mueller, T. D.; Becker, D.
- Plant Biology, Vol. 18, Issue 5
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
journal, February 2015
- Sakurai, Yasuteru; Kolokoltsov, Andrey A.; Chen, Cheng-Chang
- Science, Vol. 347, Issue 6225
Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca 2+ Currents in Isolated Lysosomes
journal, May 2010
- Schieder, Michael; Rötzer, Katrin; Brüggemann, Andrea
- Journal of Biological Chemistry, Vol. 285, Issue 28
An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles
journal, November 2009
- Brailoiu, Eugen; Hooper, Robert; Cai, Xinjiang
- Journal of Biological Chemistry, Vol. 285, Issue 5
Pharmacological properties of the Ca 2+ -release mechanism sensitive to NAADP in the sea urchin egg
journal, July 1997
- Genazzani, A. A.; Mezna, M.; Dickey, D. M.
- British Journal of Pharmacology, Vol. 121, Issue 7
Two-pore Channels Form Homo- and Heterodimers
journal, September 2011
- Rietdorf, Katja; Funnell, Tim M.; Ruas, Margarida
- Journal of Biological Chemistry, Vol. 286, Issue 43
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel
journal, August 2005
- Long, S. B.
- Science, Vol. 309, Issue 5736