Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers
Abstract
ABSTRACT For more than a decade now, biomolecular systems have served as an inspiration for the development of synthetic nanomaterials and systems that are capable of reproducing many of unique and emergent behaviors of living systems. One intriguing element of such systems may be found in a specialized class of proteins known as biomolecular motors that are capable of performing useful work across multiple length scales through the efficient conversion of chemical energy. Microtubule (MT) filaments may be considered within this context as their dynamic assembly and disassembly dissipate energy, and perform work within the cell. MTs are one of three cytoskeletal filaments in eukaryotic cells, and play critical roles in a range of cellular processes including mitosis and vesicular trafficking. Based on their function, physical attributes, and unique dynamics, MTs also serve as a powerful archetype of a supramolecular filament that underlies and drives multiscale emergent behaviors. In this review, we briefly summarize recent efforts to generate hybrid and composite nanomaterials using MTs as biomolecular scaffolds, as well as computational and synthetic approaches to develop synthetic one‐dimensional nanostructures that display the enviable attributes of the natural filaments. Biotechnol. Bioeng. 2015;112: 1065–1073. © 2015 Wiley Periodicals, Inc.
- Authors:
-
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1235339
- Alternate Identifier(s):
- OSTI ID: 1400902
- Report Number(s):
- SAND-2015-1550J
Journal ID: ISSN 0006-3592; 567369
- Grant/Contract Number:
- AC04-94AL85000
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biotechnology and Bioengineering
- Additional Journal Information:
- Journal Volume: 112; Journal Issue: 6; Journal ID: ISSN 0006-3592
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; biomineralization; energy dissipation; molecular dynamics; cytoskeleton; dynamic instability; biomolecular motors
Citation Formats
Bachand, George D., Stevens, Mark J., and Spoerke, Erik David. Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers. United States: N. p., 2015.
Web. doi:10.1002/bit.25569.
Bachand, George D., Stevens, Mark J., & Spoerke, Erik David. Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers. United States. https://doi.org/10.1002/bit.25569
Bachand, George D., Stevens, Mark J., and Spoerke, Erik David. Thu .
"Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers". United States. https://doi.org/10.1002/bit.25569. https://www.osti.gov/servlets/purl/1235339.
@article{osti_1235339,
title = {Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers},
author = {Bachand, George D. and Stevens, Mark J. and Spoerke, Erik David},
abstractNote = {ABSTRACT For more than a decade now, biomolecular systems have served as an inspiration for the development of synthetic nanomaterials and systems that are capable of reproducing many of unique and emergent behaviors of living systems. One intriguing element of such systems may be found in a specialized class of proteins known as biomolecular motors that are capable of performing useful work across multiple length scales through the efficient conversion of chemical energy. Microtubule (MT) filaments may be considered within this context as their dynamic assembly and disassembly dissipate energy, and perform work within the cell. MTs are one of three cytoskeletal filaments in eukaryotic cells, and play critical roles in a range of cellular processes including mitosis and vesicular trafficking. Based on their function, physical attributes, and unique dynamics, MTs also serve as a powerful archetype of a supramolecular filament that underlies and drives multiscale emergent behaviors. In this review, we briefly summarize recent efforts to generate hybrid and composite nanomaterials using MTs as biomolecular scaffolds, as well as computational and synthetic approaches to develop synthetic one‐dimensional nanostructures that display the enviable attributes of the natural filaments. Biotechnol. Bioeng. 2015;112: 1065–1073. © 2015 Wiley Periodicals, Inc.},
doi = {10.1002/bit.25569},
journal = {Biotechnology and Bioengineering},
number = 6,
volume = 112,
place = {United States},
year = {Thu Apr 09 00:00:00 EDT 2015},
month = {Thu Apr 09 00:00:00 EDT 2015}
}
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