On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses

Li, Anyin; Hollerbach, Adam; Luo, Qingjie; Cooks, R. Graham

doi:10.1002/anie.201501895

Title: On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses

Abstract

Abstract Relay electrospray ionization (rESI) from a capillary containing a sample solution (or from an array of such capillaries) is triggered by charge deposition onto the capillary. Suitable sources of primary ions, besides electrosprays, are plasma ion and piezoelectric discharge plasma sources. With no requirement for physical contact, high‐throughput sample screening is enabled by rapidly addressing individual secondary (sample) capillaries. Sub‐pL sample volumes can be loaded and sprayed. Polar analytes, including neurotransmitters, phosphopeptides, oligonucleotides, illicit drugs, and pharmaceutical compounds are successfully ionized by rESI with concentration sensitivities (0.1 ppb for acetylcholine) which are similar to nanoESI but absolute sensitivities are orders of magnitude better. Nonpolar analytes (steroids, alkynes) are ionized by rESI using an open‐tube secondary capillary and injecting electrolytically generated metal cations from the primary electrospray.

Authors:: Li, Anyin; Hollerbach, Adam; Luo, Qingjie; Cooks, R. Graham

Publication Date:: Fri Apr 17 00:00:00 EDT 2015

Sponsoring Org.:: USDOE

OSTI Identifier:: 1400512

Grant/Contract Number:: DE‐FG02‐06ER15807

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Angewandte Chemie (International Edition)

Additional Journal Information:: Journal Name: Angewandte Chemie (International Edition) Journal Volume: 54 Journal Issue: 23; Journal ID: ISSN 1433-7851

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: Germany

Language:: English

Citation Formats


                    Li, Anyin, Hollerbach, Adam, Luo, Qingjie, and Cooks, R. Graham. On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses.  Germany: N. p., 2015. 
Web.  doi:10.1002/anie.201501895.

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                    Li, Anyin, Hollerbach, Adam, Luo, Qingjie, & Cooks, R. Graham. On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses.  Germany.  https://doi.org/10.1002/anie.201501895

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                    Li, Anyin, Hollerbach, Adam, Luo, Qingjie, and Cooks, R. Graham. Fri .  
"On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses".  Germany.  https://doi.org/10.1002/anie.201501895.

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@article{osti_1400512,

  title        = {On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses},

  author       = {Li, Anyin and Hollerbach, Adam and Luo, Qingjie and Cooks, R. Graham},

  abstractNote = {Abstract Relay electrospray ionization (rESI) from a capillary containing a sample solution (or from an array of such capillaries) is triggered by charge deposition onto the capillary. Suitable sources of primary ions, besides electrosprays, are plasma ion and piezoelectric discharge plasma sources. With no requirement for physical contact, high‐throughput sample screening is enabled by rapidly addressing individual secondary (sample) capillaries. Sub‐pL sample volumes can be loaded and sprayed. Polar analytes, including neurotransmitters, phosphopeptides, oligonucleotides, illicit drugs, and pharmaceutical compounds are successfully ionized by rESI with concentration sensitivities (0.1 ppb for acetylcholine) which are similar to nanoESI but absolute sensitivities are orders of magnitude better. Nonpolar analytes (steroids, alkynes) are ionized by rESI using an open‐tube secondary capillary and injecting electrolytically generated metal cations from the primary electrospray.},

  doi          = {10.1002/anie.201501895},

  journal      = {Angewandte Chemie (International Edition)},

  number       = 23,

  volume       = 54,

  place        = {Germany},

  year         = {Fri Apr 17 00:00:00 EDT 2015},

  month        = {Fri Apr 17 00:00:00 EDT 2015}

}

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Title: On‐Demand Ambient Ionization of Picoliter Samples Using Charge Pulses

Abstract

Citation Formats

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry journal, January 2010

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization journal, June 2014

Mass Spectrometric Sampling of a Liquid Surface by Nanoliter Droplet Generation from Bursting Bubbles and Focused Acoustic Pulses: Application to Studies of Interfacial Chemistry journal, March 2015

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Enhanced detection of olefins using ambient ionization mass spectrometry: Ag+ adducts of biologically relevant alkenes journal, November 2010

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals journal, February 2014

Affecting Protein Charge State Distributions in Nano-Electrospray Ionization via In-Spray Solution Mixing Using Theta Capillaries journal, April 2014

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy journal, September 2014

Soft Landing of Complex Molecules on Surfaces journal, July 2011

Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics journal, February 2014

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations journal, August 2012

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling journal, November 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis journal, July 2012

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Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids journal, January 2005

Electrospray ionization for mass spectrometry of large biomolecules journal, October 1989

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation journal, January 2006

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy journal, September 2014

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels journal, October 2005

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces journal, February 1914

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals journal, February 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system journal, February 2014

Electrospray Ionization Using Wooden Tips journal, November 2011

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes journal, September 2014

Induced Nanoelectrospray Ionization for Matrix-Tolerant and High-Throughput Mass Spectrometry journal, September 2011

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization journal, October 2004

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry journal, November 2007

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In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry journal, March 2013

Application of Probe Electrospray Ionization Mass Spectrometry (PESI-MS) to Clinical Diagnosis: Solvent Effect on Lipid Analysis journal, August 2012

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry journal, January 2010

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter journal, July 2001

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification journal, December 2008

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry journal, January 1989

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics journal, July 2009

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations journal, August 2012

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm journal, August 2013

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry
journal, January 2010

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization
journal, June 2014

Mass Spectrometric Sampling of a Liquid Surface by Nanoliter Droplet Generation from Bursting Bubbles and Focused Acoustic Pulses: Application to Studies of Interfacial Chemistry
journal, March 2015

Paper-Based Microfluidic Surface Acoustic Wave Sample Delivery and Ionization Source for Rapid and Sensitive Ambient Mass Spectrometry
journal, May 2011

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry
journal, January 1995

Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions
journal, February 2009

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
journal, November 2014

Induced Nanoelectrospray Ionization for Matrix-Tolerant and High-Throughput Mass Spectrometry
journal, September 2011

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry
journal, January 2014

Microfluidic capture and release of bacteria in a conical nanopore array
journal, January 2012

Enhanced detection of olefins using ambient ionization mass spectrometry: Ag+ adducts of biologically relevant alkenes
journal, November 2010

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals
journal, February 2014

Affecting Protein Charge State Distributions in Nano-Electrospray Ionization via In-Spray Solution Mixing Using Theta Capillaries
journal, April 2014

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy
journal, September 2014

Soft Landing of Complex Molecules on Surfaces
journal, July 2011

Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics
journal, February 2014

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations
journal, August 2012

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling
journal, November 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis
journal, July 2012

Current measurements within the electrospray emitter
journal, April 2007

Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids
journal, January 2005

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation
journal, January 2006

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy
journal, September 2014

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels
journal, October 2005

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces
journal, February 1914

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals
journal, February 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system
journal, February 2014

Electrospray Ionization Using Wooden Tips
journal, November 2011

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes
journal, September 2014

Induced Nanoelectrospray Ionization for Matrix-Tolerant and High-Throughput Mass Spectrometry
journal, September 2011

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
journal, October 2004

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection
journal, May 2010

In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry
journal, March 2013

Application of Probe Electrospray Ionization Mass Spectrometry (PESI-MS) to Clinical Diagnosis: Solvent Effect on Lipid Analysis
journal, August 2012

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry
journal, January 2010

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter
journal, July 2001

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification
journal, December 2008

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry
journal, January 1989

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics
journal, July 2009

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations
journal, August 2012

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm
journal, August 2013